|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 2 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 3 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 4 | A sequential learning scheme for function approximation using minimal radial function neural networks 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1997 | Neural Computation1997，9，2： | 1 |
| 5 | Performance evaluation of a sequential minimal radial basis function (RBF) neural network learning algorithm 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1998 | IEEE Transactions on Neural Networks1998，9，2： | 1 |
| 6 | Theoretical investigation on two-phase flow instability in parallel channels under axial non- uniform heating显示文摘 | LU Xiaodong WU Yingwei ZHOU Linglan | 2014 | Annals of Nuclear Energy2014，63，1： | 1 |
| 7 | A sequential learning scheme for function approximation using minimal radial basis function neural networks 显示文摘 | Lu Yingwei Sundarajan N Saratchandran P | 1997 | Neural Network1997，9，2： | 1 |
| 8 | Performance evaluation of a sequential minimal radial basis function (RBF) neural network learning algorithm显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1998 | IEEE Trans on Neural Network1998，9，2： | 1 |
| 9 | A sequential learning scheme for function approximation using minimal radial function neural networks 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1997 | Neural Computation1997，9，2： | 1 |
| 10 | A sequential learning scheme for function approximation using minimal radial function neural networks显示文摘 | LU Yingwei SUNDARARAJAN N SARATCH ANDRAN P | 1997 | Neural Computation1997，9，2： | 1 |
| 11 | Performance evaluation of a sequential minimal radial basis function (RBF) neural network learning algorithm显示文摘 | LU Yingwei SUNDARARAJAN N SARATCH ANDRAN P | 1998 | IEEE Transactions on Neural Networks1998，9，2： | 1 |
| 12 | A sequential learning scheme for function approximation using minimal radial function neural networks显示文摘 | Yingwei Lu Sundararajan N | 1997 | Neural Computation1997，9，2： | 1 |
| 13 | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation显示文摘The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 deposition.However,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucidated.In this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 expression.Egr-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC apoptosis.More importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were identified.In vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N rats.Together,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats. | Fengxia He Mengya Zhou Tianyi Yu Dan Zhao Jing Zhang Wen Qiu Yanlai Lu Yu Liu Lulu Wang Yingwei Wang | 2016 | Journal of Molecular Cell Biology2016，8，6： | 1 |
| 14 | Performance evaluation of a sequential minimal radial basis function (RBF) neural network learning algorithm 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1998 | IEEE Transactions on Neural Networks1998，9，2： | 1 |
| 15 | Endomorphins and morphine limit anoxia–reoxygenation-induced brain mitochondrial dysfunction in the mouse显示文摘 | Yun Feng Yingwei Lu Xin Lin Yanfeng Gao Qianyu Zhao Wei Li Rui Wang | 2008 | Life Sciences2008，，13： | 1 |
| 16 | Performance evaluation of a sequential minimal radial basis function (RBF) neural network learning algorithm显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1998 | IEEE Transactions on Neural Networks1998，9，2： | 1 |
| 17 | Improve- ment of photoluminescence properties of porous sili- con by silicon passivation 显示文摘 | Du Xiwen Lu Yingwei Liu Junpeng | 2005 | Applied Surface Sci- ence2005，252，12： | 1 |
| 18 | A sequential learning scheme for function approximation using minimal radial function neural networks 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1997 | Neural Computation1997，9，2： | 1 |
| 19 | Performance evaluation of a sequential minimal radial basis function neural network learning algorithm 显示文摘 | LU Yingwei SUNDARARAJAN N SARATCHANDRAN P | 1998 | IEEE Transactions on Neural Networks1998，9，2： | 1 |
| 20 | A sequential learning scheme for function approximation using minimal radial function neural networks 显示文摘 | Lu Yingwei Sundararajan N Saratchandran P | 1997 | Neural Computation1997，9，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员