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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 3 | The 'stone-like' pattern of LC3A expression and its elinicopathologic significance in hepato-cellular carcinoma显示文摘 | Xi SY Lu JB Chen JW | 2013 | Biochem Biophys Res Commun2013，431，4： | 1 |
| 4 | Powder Microelectrodes Applied to NO2- Detection显示文摘TheelectrochemicalbehaviorsandthedetectionofNO2-haveattractedincreasingattentionrecentlybecauseoftheimportantrolesplayedbyNO2-inenvironmentandlifeprocesses.Thus,advancedtechniquesforthedetermination,especiallyon-sitedetermination,ofthenitriteinfoods... | Yan, JW Lu, JT Liu, PF | 1999 | Chinese Chemical Letters1999，10，1： | 1 |
| 5 | Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos显示文摘 | Yang D Lu H Erickson JW | 2000 | Curr Biol2000，10，19： | 1 |
| 6 | A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mos- quito cells显示文摘 | Hobson-Petem J Yam AW Lu JW | 2013 | PLoS One2013，8，56： | 1 |
| 7 | A role of galanin in antidepressant actions with a focus on the dorsal raphe nucleus显示文摘 | Lu X Barr AM Kinney JW | 2005 | Proc Natl Acad Sci U S A2005，102，3： | 1 |
| 8 | Liver development and c-ancer formation in zebrafish显示文摘 | Lu JW Hsia Y Tu HC | 2011 | Birth Defects Res C Embryo Today2011，93，2： | 1 |
| 9 | Face recognition using the nearest feature line method显示文摘 | LI SZ LU JW | 1999 | IEEE Transactions on Neural Networks1999，10，2： | 1 |
| 10 | Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparti- cles显示文摘 | Liu JW Lu Y | 2006 | Angew Chem2006，45，1： | 1 |
| 11 | Hepatocellular carcinoma:USguided percutaneous microwave coagulation therapy显示文摘 | Lu MD Chen JW Xie XY | 2001 | Radiology2001，221，1： | 1 |
| 12 | Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats 显示文摘 | Lu SY Liao JW Kuo ML | 2004 | J Toxicol Environ Health A2004，67，： | 1 |
| 13 | Realgar, cinnabar and An-Gong-NiuHuang Wan are much less chronically nephrotoxic than common arsenicals and mercurials显示文摘 | Lu YF Wu Q Yan JW | 2011 | Exp Biol Med (Maywood)2011，236，2： | 1 |
| 14 | Realgar-and cinnabar-containing An-Gong-Niu-Huang Wan (AGNH)is much less acutely toxic than sodium arsenite and mercuric chloride显示文摘 | Lu YF Yan JW Wu Q | 2011 | Chemico-Biolog- ical Interactions2011，189，12： | 1 |
| 15 | Evidence that processed smalt dsRNAs may mediate sequence-speci/ic mRNA degradation during RNAi in Drosophila embryos 显示文摘 | Yang D Lu H Eriekson JW | 2000 | Current Biology2000，10，19： | 1 |
| 16 | Time - dependent increases in brain - derived neurotrcphic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving 显示文摘 | Grimm JW Lu L Hayashi T | 2003 | J Neurosci2003，23，3： | 1 |
| 17 | Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis显示文摘 | LU JW WANG H YAN-LI J | 2008 | J Hepatol2008，48，3： | 1 |
| 18 | Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving 显示文摘 | Grimm JW Lu L Hayashi T | 2003 | J Neurosci2003，23，3： | 1 |
| 19 | Hepatocellular carcinoma:US-guided percutaneous microwave coagulation therapy显示文摘 | Lu MD Chen JW Xie XY | 2001 | Radiology2001，221，： | 1 |
| 20 | The relationship between solitary pulmonary nodules and bronchi:multi-slice CT-pathological correlation显示文摘 | Qiang JW Zhou KR Lu G | 2004 | Clin Radiol2004，59，12： | 1 |
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