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	题名	作者	年代	出处	被引量
1	Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells.	Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak	2014	International Journal of Ophthalmology(English edition)2014，7，2：	4
2	Structure of the mature Streptococcal cysteine protease exotoxin mSpeB in its active dimer- ic form显示文摘	lsen JG Dagil R Niclasen LM	2009	J Mol Biol2009，393，3：	1
3	Cerebral blood vessel by lesioninng of the trigeminal nerve possible involvement of CGRP显示文摘	Edvinsson L Jansen O Lsen L	1995	Cepgalagia1995，15，5：	1
4	Multilocular cystic nephroma: an unusual localization显示文摘	Ali Riza Kural Can ?bek Gülsen ?zbay Ali Ulvi ?nder	1998	Urology1998，，5：	1
5	Treatment of ureteral stones comparison of exfraeorporeal shock wave lithotripsy and endourology ahematives显示文摘	KUPELI B BIRI H LSEN K	1998	Eur-urol1998，3，4：	1
6	Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation显示文摘	Larsen FS O lsen KS Hansen BA	1994	Stroke1994，25，10：	1
7	Laser-modified aluminium surfaces with iron 显示文摘	GJNNES L O LSEN A	1994	Journal of Materials Science1994，29，：	1
8	The formalin test: an evaluation of the method显示文摘	Tj lsen A Berge DG Hunskaar S	1992	Pain1992，485，：	1
9	Under control of the Ren- 1 promoter, locally produced transforming growth factor β1induces accumulation of glormerular extracellular matrix in transgenic mice 显示文摘	Nie lsen CB Hjorth P	1999	Diabetes1999，48，1：	1
10	Topical aspirin plus HCL gastric lesion in the rat显示文摘	Guth P H Aures D Pan lsen G	1979	Gastroenterology1979，76，1：	1
11	A choice of death-the signal transduction of immol/Lune-mediated beta-cell apoptosis显示文摘	Eizirik DL Mandrup-PoμLsen T	2001	Diabetologia2001，44，12：	1
12	Globle Patterns of In fluenza A Virus in Wild Birds显示文摘	()lsen B Munster V J Wallensten A etal	2006	Science2006，312，38：	1
13	Lumbar catheter- ization of the spinal subarachnoid space in the rat 显示文摘	Stφkson RV Kjcrsvik K Tjφlsen A	1996	J Neurosci Meth1996，65，2：	1
14	A rare metabolic complication of acute lymphoblastic leukemia in childhood:lactic acidosis显示文摘	Gokce M Unal S Gülsen H	2012	Turk J Pediatr2012，54，：	1
15	Commis surotomy for mitral stenosis; technique for prevention of cerebral complications显示文摘	BAILEY C P ()LSEN A K KEOWN K K	1952	J Am Med Assoc1952，149，12：	1
16	Short term efficacy of pulsed electromagnetic field therapy on pain and functional level in knee osteoarthritis:a randomized control ed study显示文摘	Külcü DG Gülsen G Altunok EC		0，，24：	1
17	C olor2gray: saliencepre se rv in g c o lo r re m o v a l显示文摘	G o o ch A A O lsen S C T u m b lin J		A C M T ran sactions o n G rap h ics0，24，3：	1
18	Global pattern of influenza A virus in wild birds显示文摘	O lsen B Mun ster V J Wallenslen A W	2006	Science2006，312，3：	1
19	The formalin test: an evaluation of the method显示文摘	TJo LSEN A BERGE OG HUNSKAAR S	1992	Pain1992，51，：	1
20	International Spread of Bla(emy-2)-Mediated Cephalosporin Resist- ance in a Multiresistant Salmonella Enteriea Serovar Heidelberg Isolate Stemming from the Importation of a Boar by Den- mark from Canada 显示文摘	AARESTRUP F M H ASMAN H O LSEN I	2009	Antimicrob Agents Chemother2009，48，5：	1

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