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| 1 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 2 | Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of most common malignancies in the world. Systemic treatments for HCC, particularly for advanced stages, are limited by the drug resistance phenomenon which ultimately leads to therapy failure. Recent studies have indicated an association between drug resistance and the existence of the cancer stem cells (CSCs) as tumor initiating cells. The CSCs are resistant to conventional chemotherapies and might be related to the mechanisms of the ATP Binding Cassette (ABC) transporters and alterations in the CSCs signaling pathways. Therefore, to contribute to the development of new HCC treatments, further information on the characterization of CSCs, the modulation of the ABC transporters expression and function and the signaling pathway involved in the self renewal, initiation and maintenance of the cancer are required. The combination of transporters modulators/inhibitors with molecular targeted therapies may be a potent strategy to block the tumoral progression. This review summarizes the association of CSCs, drug resistance, ABC transporters activities and changes in signaling pathways as a guide for future molecular therapy for HCC. | Caecilia HC Sukowati Natalia Rosso Lory S Crocè Claudio Tiribelli | 2010 | World Journal of Hepatology2010，2，3： | 16 |
| 3 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 4 | Induction of HIV-specific memory T-cell responses by topical DermaVir vaccine显示文摘 | CALAROTA S A WEINER D B LORI F | 2007 | Vaccine2007，25，16： | 1 |
| 5 | Manufacturing and service supply chain perfor- mance: a comparative analysis显示文摘 | Kaushik Sengupta Daniel R Heiser Lori S Cook | 2006 | The Journal of Supply Chain Management2006，42，4： | 1 |
| 6 | A phase 3, muhicenter, double- blind, placebo-controlled trim of lenvatinib ( E7080 ) in patients with 131I-refractory differentiated thyroid cancer (SELECT) 显示文摘 | Martin S Makoto T Lori JW | 2014 | J Clin Oncol2014，32，： | 1 |
| 7 | Intestinal uptake and biliary ex- cretion of the isoflavone genistein in rats 显示文摘 | Jeff S Lori C Marion K | 1997 | J Nutr1997，127，7： | 1 |
| 8 | First report of Fusarium solani causing stunt on lisianthus 显示文摘 | WOLCAN S LORI G RONCO L | 2001 | Plant Disease2001，85，4： | 1 |
| 9 | Cognitive and psychosocial features in childhood and juvenile MS: Twu-year follow-up显示文摘 | Amato MP Goretti B Ghezzi A Lori S Zipoli V Moiola L | 2010 | Neurology2010，75，13： | 1 |
| 10 | Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo Study显示文摘 | Lori B Daniel S Gail A | 2008 | J Am Coll Cardiol2008，51，9： | 1 |
| 11 | Zinc, thymic endocrine activity and mitogen responsiveness (PHA) in piglets expose tomaternal aflatoxicosis Bland G显示文摘 | Eugenio M Attilio C Lory S | 1998 | Vet Immunol Immunopathol1998，62，： | 1 |
| 12 | Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease显示文摘 | Muller S Lory J Corazza N | 1998 | AmJPathol1998，152，1： | 1 |
| 13 | Patterning Cells in Highly Deformable Microstructures: Effect of Plastic Deformation of Substrate on Cellular Phenotype and Gene Expression显示文摘 | Hyun J H Chen J S Lori A | 2006 | Biomaterials2006，27，8： | 1 |
| 14 | Systemic-to-pulmonary collateral vessels and shunt:treatment with embolization显示文摘 | Loris Jf Gomes A S Smith D C | 1988 | Radiology1988，169，： | 1 |
| 15 | Antitumor and anti- angiogenic activities of Scutellaria barbata extracts in vitro are partially mediated by inhibition of Akt/protein kinase S 显示文摘 | Zhi H Z Lori H When S | 2012 | Molecular Medicine Reports2012，5，3： | 1 |
| 16 | Single institution experience treating 104 vestibular schwannomas with fractionated stereotactic radiation therapy or stereotactic radiosurgery显示文摘 | Bethany M. Anderson Deepak Khuntia S?ren M. Bentzen Heather M. Geye Lori L. Hayes John S. Kuo Mustafa K. Baskaya Behnam Badie Amar Basavatia G. Mark Pyle Wolfgang A. Tomé Minesh P. Mehta | 2014 | Journal of Neuro-Oncology2014，，： | 1 |
| 17 | Biomechanical factors in tissue engineered meniscal repair显示文摘 | FARSHID G EDWARD WH | 1999 | J Orthop Res1999，367，： | 1 |
| 18 | Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada显示文摘 | LORI L SHIRLEY A S KURTIS S | 2006 | Science of the Total Environment2006，367，1： | 1 |
| 19 | Interstrain transfer of the large pathogenicity island (PAPI-1) of Pseudomonas aeruginosa显示文摘 | Qiu X Gurkar AU Lory S | 2006 | Proc Natl Acad Sci USA2006，103，19： | 1 |
| 20 | Heuristic algorithms and scatter search for the cardinality constrained PHCmx problem 显示文摘 | Dell'Amico M Lori M Martello S | 2004 | Journal of Heuristics2004，，： | 1 |
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