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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Percutaneous sclerotherapy for lymphatic malformations:a retrospective analysis of patient-evaluated improvement显示文摘 | Alomari A I Karian V E Lord D J | 2006 | J Vasc Interv Radiol2006，17，10： | 1 |
| 3 | Effects of child characteristics on the autism diagnostic interview-revised:implications for use of scores as a measure of ASD severity 显示文摘 | Hus V Lord C | 2013 | J Autism Dev Disord2013，43，2： | 1 |
| 4 | S-100 positive cells in human arterial intima and in atherosclerotic lesions 显示文摘 | Bobryshev Y V Lord R S | 1995 | Cardiovasc Res1995，29，5： | 1 |
| 5 | DNA repair and cisplatin resistance in non-small-cell lung cancer显示文摘 | Rosell R Lord R V Taron M | 2002 | Lung Cancer2002，38，3： | 1 |
| 6 | DNA repair and cisplatin resistance in non-small cell lung cancer显示文摘 | Rosell R Lord R V Taron M | 2002 | Lung Cancer2002，38，3： | 1 |
| 7 | Field study of vaccination of cattle with Brucella abortus strains RBS1 and 19 under high and low disease prevalence显示文摘 | Lord V R Schurig G G Cherwonogrodzky J W | 1998 | Am J Vet Res1998，59，8： | 1 |
| 8 | Emergency physician recognition of adverse drug-related events in elder patients presenting to an emergency department显示文摘 | Hohl CM Robitaille C Lord V | 2005 | Acad Emerg Med2005，12，3： | 1 |
| 9 | LowERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung can-cer显示文摘 | LORD R V BRABENDER J GANDARA D | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 10 | Low ERCCI expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung Cancer显示文摘 | LORD R V BRABENDER J GANDARA D | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 11 | Mapping of vascular dendritic cells in atherosclerotie arteries suggests their involvement in local immuneinflammatory reactions 显示文摘 | Bobryshev Y V Lord R S | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 12 | Benthic ostracods and deep water-masses in the Atlantic Ocean 显示文摘 | Dingle R V Lord A R | 1990 | Palaeogeography Palaeoclimatology Pataeoecology1990，80，34： | 1 |
| 13 | Co-accumulation of dendritic cells and natural killer T cells within rupture-prone regions in human atherosclerotic plaques显示文摘 | Bobryshev Y V Lord RSA | 2005 | J Histochem Cytochem2005，53，6： | 1 |
| 14 | Granzyme B:a natural born killer显示文摘 | Lord S J Rajotte R V Korbutt G S | | 0，，01： | 1 |
| 15 | T-bet, a Thl transcription factor regulates the expression of Tim-3 显示文摘 | Anderson AC Lord GM Dardalhon V | 2010 | Eur J Immuno12010，40，： | 1 |
| 16 | DNA repair and cisplatin resistance in non-small-cell lung cancer显示文摘 | Rosell R lord R V Taren M | 2002 | Lung Cancer2002，38，4： | 1 |
| 17 | Clustering of dendritic cells in athero-prone areas of the aorta显示文摘 | Lord R S Bobryshev Y V | 1999 | Atherosclerosis1999，146，1： | 1 |
| 18 | Low ERCC 1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell Lung cancer 显示文摘 | Reginald V Lord N Brabender J | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 19 | Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenoearcinoma显示文摘 | Kawakami K Brabender J Lord R V Groshen S Greenwald B D Krasna M J | 2000 | J Natl Cancer Inst2000，92，： | 1 |
| 20 | DNA repair and cisplatin resistance in non-small-cell lung cancer 显示文摘 | Rosell R Lord R V Taron M | 2002 | Lung Cancer2002，38，3： | 1 |
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