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| 1 | Some key technics of drop tower experiment device of National Microgravity Laboratory (China) (NMLC)显示文摘Drop tower is an important ground based facility for microgravity science experiment. The technical performances of the drop tower NMLC are advanced compared with similar facilities in the US, Germany and Japan. The main components such as drop capsule, deceleration devices, release mechanism present its advantages and creativities. | ZHANG Xiaoqian 1 , YUAN Longgen 1 , WU Wendong 1 , TIAN Lanqiao 2 & YAO Kangzhuang 2 1. Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100080, China 2. Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Science China(Technological Sciences)2005，48，3： | 4 |
| 2 | Measuring the Spillover Eeffects: Some Chinese Evidence 显示文摘 | Ying Longgen | 2000 | Papers in Regional Science2000，79，： | 1 |
| 3 | EXPERT CONTROL SYSTEM FOR COAL BLENDING PROCESS IN AN IRON AND STEEL CORPORATION显示文摘1INTRODUCTIONAsakindofinteligentmethod,expertcontrolcandealwithalkindsofquantitativeorqualitative,preciseorfuzzyinformationb... | Yang, Chunhua Shen, Deyao Wu, Min Hu, Longgen | 1999 | 中国有色金属学会会刊:英文版1999，9，2： | 1 |
| 4 | Effecls of nitrogen and phosphorus from fish cage -culture on the communities of a shallow lake in middle Yangtze River basin of China 显示文摘 | Longgen G Zhongjie L | 2003 | Aquaculture2003，226，： | 1 |
| 5 | Measuring the spillover effects: some Chinese evidence 显示文摘 | YING Longgen | 2000 | Papers in Regional Science2000，79，1： | 1 |
| 6 | Understanding China's recent growth experience: a spatial econometric perspective 显示文摘 | YING Longgen | 2003 | The Annals of Regional Science2003，37，4： | 1 |
| 7 | Effects of nitrogen and phosphorus from fish cage: Culture on the communities of a shallow lake in middle Yangtze River basin of China显示文摘 | Longgen G Zhongjie L | 2003 | Aquaculture2003，226，： | 1 |
| 8 | The influence of immunosuppressants on the fertility of males who undergo renal transplantation and on the immune function of their offspring显示文摘 | Longgen Xu Shu Han Yong Liu Hongwei Wang Yirong Yang Feng Qiu Wanling Peng Ligong Tang Jing Fu Xiao-Feng Zhu Xianfan Ding Youhua Zhu | 2009 | Transplant Immunology2009，，： | 1 |
| 9 | Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail ( Bellamya aeruginosa ) from a large shallow, eutrophic lake of the subtropical China显示文摘 | Jun Chen Ping Xie Longgen Guo Li Zheng Leyi Ni | 2004 | Environmental Pollution2004，，3： | 1 |
| 10 | In situ study on th econtrol of toxic Microcystis blooms using phytop lank tivorous fish in the sub tropical Lake Taihu of China:A large fish fenexperiment 显示文摘 | Zhixin Ke Ping Xie Longgen Guo etal | 2007 | Aquaculture2007，，265： | 1 |
| 11 | Measuring the Spillover Effects: Some Chinese Evidence 显示文摘 | Ying Longgen | 2000 | Papers in Regional Science2000，79，： | 1 |
| 12 | Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China 显示文摘 | Jun Chen Ping Xie Longgen Guo | 2005 | Environmental Pollution2005，，134： | 1 |
| 13 | In situ study on the control of toxic Microcystis blooms using phytoplanktivorous fish in the subtropical Lake Taihu of China: A large fish fen experiment 显示文摘 | Zhixin Ke Ping Xie Longgen Guo | 2007 | Aquaculture2007，，265： | 1 |
| 14 | In situ study on the control of toxic Microcystis blooms using phytoplanktivorous fish in the subtropical Lake Taihu of China: A large fish pen experiment显示文摘 | Zhixin Ke Ping Xie Longgen Guo Yaqin Liu Hua Yang | 2007 | Aquaculture2007，，1： | 1 |
| 15 | In situ studies on physiological and biochemical responses of four fishes with different trophic levels to toxic cyanobacterial blooms in a large Chinese lake显示文摘 | Tong Qiu Ping Xie Zhixin Ke Li Li Longgen Guo | 2007 | Toxicon2007，，3： | 1 |
| 16 | Poly-linker primer system for detection of single nucleotide polymorphisms and its application in genotyping hepatitis B virus显示文摘 | YongzhongWang Bo-Yu Xue Longgen Liu Zhen Zhu Xin Xu Hongyu Zhang Xiangke Pu Xiaoqin Liu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 0 |
| 17 | Murine double minute gene 2(MDM2)promoted hepatocellular carcinoma(HCC)cell growth by targeting fructose-1,6-bisphosphatase(FBP1)for degradation显示文摘To study the roles and association of murine double minute gene 2(MDM2)and fructose-1,6-biphosphatase(FBP1)in human hepatocellular carcinoma(HCC),growth response of human HCC cells was assessed using proliferation and apoptosis assay.Pro-survival AKT signaling associated proteins(p-AKT,survivin and cleaved caspase 3)were assessed using western blotting.The correlation between MDM2 and FBP1 was assessed using coimmunoprecipitation combined with ubiquitination assay.Our data suggested that low expression of FBP1 was correlated with high levels of MDM2 in HCC cell lines(Huh7 and Hep3B).Overexpression of FBP1 resulted in antiproliferation,pro-apoptosis,the up-regulation of cleaved caspase 3 while the downregulation of survivin and phosphor(p)-AKT,however,knockdown of FBP1 led to the opposite.Furthermore,overexpression of MDM2 potently reversed FBP1-induced proliferation inhibition and apoptosis,while Nutlin-3(an MDM2 inhibitor)reversed the change trends induced by FBP1 knockdown in the aforementioned events.Lastly,but not least importantly,our data elucidated that MDM2 binds directly to FBP1 and promotes FBP1 ubiquitination.In conclusion,our data firstly suggested the involvement of FBP1 and its association with MDM2 in HCC cell growth.MDM2-FBP1-regulated HCC cell growth and the activation of AKT were mediated,at least in part,through FBP1 degradation. | YAO XU BIN WU JING YANG SHENG ZHANG LONGGEN LIU SUOBAO XU JIAKAI JIANG | 2022 | BIOCELL2022，46，6： | 0 |
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