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| 1 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 2 | Identification of an atyp- ical Grb2 carboxyl - terminal SH3 domain binding site in Gab docking proteins reveals Grb2 - dependent and - independent re- cruitment of Gabl to receptor tyrosine kinases显示文摘 | Lock LS Royal I Nanjokas MA | 2000 | J Biol Chem2000，275，31： | 1 |
| 3 | Identification of an atypical Grb2 earboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and-independent recruitment of Gabl to receptor tyrosinekinases显示文摘 | Lock LS Royal I Naujokas MA | 2000 | J Biol Chem2000，275，31： | 1 |
| 4 | Acaricide treatment affects viral dynamics in Varroa destructor-infested honey bee colo nies via both host physiology and mite control显示文摘 | Locke B Forsgren E Fries I | 2011 | Appl Environ Microbiol2011，78，： | 1 |
| 5 | What predicts maintenance of weight for adolescents medically hospitalized for anorexia nervosa?显示文摘 | Lock J Litt I | 2003 | Eat Disord2003，11，1： | 1 |
| 6 | Identification of an a typical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2 dependent and-independent recruitment of Gab1 to receptor tyrosine kinases 显示文摘 | Lock L S Royal I Naujokas M A | 2000 | J Biol Chem2000，275，31： | 1 |
| 7 | Using an integrated modelling approach for risk assessment of the 'killer shrimp' Dik- erogammarus Villosus 显示文摘 | BOETS P PAUWELS I S LOCK K | 2014 | River Research and Applications2014，30，： | 1 |
| 8 | Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and-independent recruitment of Gabl to receptor tyrosine kinases 显示文摘 | Lock L S Royal I Naujokas M A | 2000 | J Biol Chem2000，275，31： | 1 |
| 9 | Decomposition of phenol by hybrid gas/liquid electrical discharge reactors with zeolite catalysts显示文摘 | Ku(s)i(c) H Koprivanac N Locke B R | 2005 | Journal of Hazardous Materials2005，125，： | 1 |
| 10 | Role of the integrin-linked kinase(ILK)/Rictor complex in TGFβ1-induced epithelial-mesenchymal transition(EMT)显示文摘 | Serrano I McDonald PC Lock FE | 2013 | Oncogene2013，32，1： | 1 |
| 11 | Role of the in- tegrin- linked kinase (ILK)/Rictor complex in TGF13-1 - induced epithelial - mesenchymal transition (EMT) 显示文摘 | Serrano I McDonald P C Lock F E | 2013 | Oncogene2013，32，1： | 1 |
| 12 | Role of the integrin-linked kinase(ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition(EMT)显示文摘 | Serrano I Mcdonald PC Lock FE | 2013 | Oncogene2013，32，1： | 1 |
| 13 | Role of the integrin-linked kinase (ILK)/Rictor complex in TGFbeta-l-induced epithelial-mesen- chymal transition (EMT) 显示文摘 | Serrano I McDonald P C Lock F E | 2013 | Oncogene2013，32，1： | 1 |
| 14 | Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gerle mutation carriers and mutation-negative con- trols显示文摘 | Locke I Kote-Jarai Z Fackler M J | 2007 | Breast Cancer Res2007，9，1： | 1 |
| 15 | Energy requirement for the flight of micro air vehicles显示文摘 | Woods M I Henderson J F Lock G D | 2001 | The Aeronauical Journal2001，，3： | 1 |
| 16 | Treatment of Depression in Patients with Epilepsy显示文摘 | Noe K H Locke D E Sirven J I | 2011 | Treat Options Neurol2011，7，22： | 1 |
| 17 | Early nutrition support in theintensive care unit : a US perspective 显示文摘 | Scur lock C Mechanick J I | 2008 | Curr Opin Clin NutrMetab Care2008，11，2： | 1 |
| 18 | A comparison of fluorescent CaCa2+ indicators for imaging local CaCa2+ signals in cul- tured (:ells 显示文摘 | Lock JT Parker I Smith IF | 2015 | Cell Calcium2015，58，： | 1 |
| 19 | Psychosocial fac- tors axe linked to functional gastrointestinal disorders: a popula- tion based nested case - control study 显示文摘 | Locke GR Weaver AL Melton I j Talley NJ | 2004 | Am J Gastroenterol2004，99，2： | 1 |
| 20 | Role of the integrin-linked kinase(ILK)/Rictor complex in TGFbeta-1-inducedepithelial-mesenchymal transition(EMT)显示文摘 | Serrano I McDonald PC Lock FE | 2013 | Oncogene2013，32，1： | 1 |
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