|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Acute bilateral vitreo-ret-inal hemorrhage following oxygen-ozone therapyfor lumbar disk herniation 显示文摘 | Lo Giudice G Valdi F Gismondi I | 2004 | Am J Ophthlmol2004，138，： | 1 |
| 3 | Lipolytic activity of Antarctic cold-adapted marine bacteria (Terra Nova Bay, Ross Sea)显示文摘 | Lo Giudice A Michaud L De Pascale D | 2006 | Journal of Applied Microbiology2006，101，5： | 1 |
| 4 | Acute bilateral retinal hemorrhages, following oxygen-ozone therapy tbr lumbar disk-herniation disk hemiation显示文摘 | Lo Giudice G Valdi F Gismondim | 2004 | Am J opbthatmol2004，，13： | 1 |
| 5 | Lincomycin solar photodegradation, algal toxicity and removal from wastewaters by means of ozonation 显示文摘 | Andreozzi R Canterino M Lo Giudice R | 2006 | Water Res2006，40，： | 1 |
| 6 | Acule bilateral vitreoretinal hemorrhage following oxygen-ozone therapy for lumbar disk hemiation显示文摘 | Lo Giudice Valdi F Gismondi I | 2004 | AmJ Ophtalniol2004，138，1： | 1 |
| 7 | Dentin morphology of root canal surface:A quantitative evaluation based on a scanning electronic microscopy study显示文摘 | Lo Giudice G Cutroneo G Centofanti A | 2015 | Biomed Res Int2015，2015，16： | 1 |
| 8 | Acule bilateral vitreo retinal hemorrhage following oxygen ozone therapy for lumbar disk herniation 显示文摘 | Lo Giudice G Valdi F Gismond I | 2004 | Am J Ophtalniol2004，138，1： | 1 |
| 9 | Acule bilateral vitreo-retinalhemorrhage following oxygen-ozone therapy for lumbar disk hemia-tion显示文摘 | Lo Giudice Valdi F Gismondi I | 2004 | Am J Ophtalniol2004，138，1： | 1 |
| 10 | Lincomycin solar photodegradation, algal toxicity and removal from wastewaters by means of ozonation显示文摘 | Andreozzi R Canterino M Lo Giudice R | 2006 | Water Res2006，40，： | 1 |
| 11 | Acule bilateral vitreoretinal hemorrhage following oxygen-ozone therapy for lumbar disk herniation 显示文摘 | LO GIUDICE VALDI F GISMONDI I | 2004 | AmJ Ophtalniol2004，138，1： | 1 |
| 12 | C/N ratio-induced structural shift of bacterial communities inside lab-scale aquaculture biofilters显示文摘 | Michaud L Lo Giudice A Interdonato F | 2014 | Aquacult Eng2014，58，： | 1 |
| 13 | Propionyl-L-Camitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction显示文摘 | Scioli MG Lo Giudice P Bielli A | 2015 | PLoS One2015，10，01： | 1 |
| 14 | Istaroxime:a new luso-inotropic agent for heart failure显示文摘 | MATTERA G G LO GIUDICE P LOI F M | 2007 | Am J Cardiol2007，99，2： | 1 |
| 15 | Acule bilateral vitreo retinal hemorrhage following oxygen ozone therapy for lumbar disk herniation显示文摘 | Lo Giudice Valdi F Gismondi I | 2004 | AmJ Ophtalniol2004，138，1： | 1 |
| 16 | Morphology and LPS content for the estimation of marine bacterioplankton biomass in the Ionian Sea显示文摘 | La Ferla R Lo Giudice A Maimone G | 2004 | Scientia Marina2004，68，1： | 1 |
| 17 | Improving visual functions in adult amblyopia with combined perceptual training and transcranial random noise stimulation (tRNS):a pilot study显示文摘 | CAMPANA G CAMILLERI R PAVAN A VERONESE A LO GIUDICE G | 2014 | Front Psychol2014，9，5： | 1 |
| 18 | Acule bilateral vitreoretinal hemorrhage following ox- ygen ozone therapy for lumbardisk herniation 显示文摘 | Lo Giudice G Valdi F Gismond I | 2004 | Am J Ophtalniol2004，138，1： | 1 |
| 19 | Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin,without altering its antitumor properties显示文摘 | Ghirardi O Lo Giudice P Pisano C | | 0，，04： | 1 |
| 20 | Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac显示文摘 | Ferrari B Paxeus N Lo Giudice It | 2003 | Ecotoxicology and Environmental Safety2003，55，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员