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| 1 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 2 | How to predict clinical relapse in inflammatory boweldisease patients显示文摘Inflammatory bowel diseases have a natural course characterized by alternating periods of remission and relapse. Disease flares occur in a random way and are currently unpredictable for the most part. Predictors of benign or unfavourable clinical course are required to facilitate treatment decisions and to avoid overtreatment. The present article provides a literature review of the current evidence on the main clinical, genetic, endoscopic, histologic, serologic and fecal markers to predict aggressiveness of inflammatory bowel disease and discuss their prognostic role, both in Crohn's disease and ulcerative colitis. No single marker seems to be reliable alone as a flare predictor, even in light of promising evidence regarding the role of fecal markers, in particular fecal calprotectin, which has reported good results recently. In order to improve our daily clinical practice, validated prognostic scores should be elaborated, integrating clinical and biological markers of prognosis. Finally, we propose an algorithm considering clinical history and biological markers to intercept patients with high risk of clinical relapse. | Elisa Liverani Eleonora Scaioli Richard John Digby Matteo Bellanova Andrea Belluzzi | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 3 | Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents显示文摘The use of bioactive glass(BG)particles as a filler for the development of composite electrospun fibers has already been widely reported and investigated.The novelty of the present research work is represented by the use of benign solvents(like acetic acid and formic acid)for electrospinning of composite fibers containing BG particles,by using a blend of PCL and chitosan.In this work,different BG particle sizes were investigated,namely nanosized and micron-sized.A preliminary investigation about the possible alteration of BG particles in the electrospinning solvents was performed using SEM analysis.The obtained composite fibers were investigated in terms of morphological,chemical and mechanical properties.An in vitro mineralization assay in simulated body fluid(SBF)was performed to investigate the capability of the composite electrospun fibers to induce the formation of hydroxycarbonate apatite(HCA). | Liliana Liverani Jonas Lacina Judith A.Roether Elena Boccardi Manuela S.Killian Patrik Schmuki Dirk W.Schubert Aldo R.Boccaccini | 2018 | Bioactive Materials2018，3，1： | 4 |
| 4 | Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications显示文摘Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound healing.In this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO system.With the intention of adding subsidiary biological function,MBGNs were doped with Zn2+ions.Zn-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel method.The synthesized particles were homogeneous in shape and size.They exhibited spherical shape,good dispersity,and a size of 130±10 nm.The addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to MBGNs.The presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of immersion.Interestingly,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained manner.This releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of cells.Due to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing. | Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini | 2019 | Bioactive Materials2019，4，1： | 3 |
| 5 | A fast interactive reverse-engineering system显示文摘 | Beccari C V Farella E Liverani A | 2010 | Computer-Aided Design2010，42，10： | 1 |
| 6 | One-step laparoscopic and endoscopic treatment of gallbladder and common bile duct stones : our experience of the last 9 years in a retrospective study 显示文摘 | Liverani A Muroni M Santi F | 2013 | Am Surg2013，79，12： | 1 |
| 7 | Susceptibility to highly sulphated glycosaminoglycans of human immunodeficiency virus type 1 replication in peripheral blood lymaphocytes and monocyte-derived macrophages cell culture 显示文摘 | BARTOLINI B DIi-CARO A LIVERANI L | 2003 | Antiviral Research2003，58，2： | 1 |
| 8 | Optical coherence tomography for classification and clinical evaluation of macular edema in patients with uveitis显示文摘 | Iannetti L Accorinti M Liverani M | 2008 | Ocul Immunol Inflamm2008，16，4： | 1 |
| 9 | A CAD-augmented reality integrated environment for assembly sequence check and interactive validation显示文摘 | Liverani A Amati G Caligiana G | | 0，，03： | 1 |
| 10 | Applicative aspects of liq- uid-based cytology in cervical cancer screening 显示文摘 | Liverani M De Paola F Danesi S | 2006 | Pathologica2006，98，6： | 1 |
| 11 | Clinical features and prognosis of HLA B27-associated acute anterior uveitis in an Italian patient population显示文摘 | Accorinti M Iannetti L Liverani M | 2010 | Ocol Immunol Inflamm2010，2，12： | 1 |
| 12 | Clinical Features and Prog- nosis of HLA B27-associated Acute Anterior Uveitis in an Italian Pa- tient Population显示文摘 | Accorinti M Iannetti L Liverani M | 2010 | Ocular Immunology and Inflammation2010，18，2： | 1 |
| 13 | Reconsidering Primary HPV Testing in Cervical Cancer Screening显示文摘 | Carlo Antonio Liverani | 2015 | Journal of Life Sciences2015，9，2： | 1 |
| 14 | A CAD-augmented reality integrated environment for assembly sequence check and interactive validation 显示文摘 | Liverani A Amati G Caligiana G | 2004 | Concurrent Engineering: Research and Application2004，12，1： | 1 |
| 15 | IL-17A increases AOP-induced platelet aggregation显示文摘 | Maione F Cicala C Liverani E | 2011 | Biochem Biophys Res Commun2011，408，4： | 1 |
| 16 | Towards Interactive Finite Element Analysis of Shell Structures in Virtual Reality 显示文摘 | A Liverani F Kuester B Hamann | 1999 | IEEE1999，，： | 1 |
| 17 | PDK1 selectively phosphorylates Thr(308)on Akt and contributes to human platelet functional responses显示文摘 | Dangelmaier C Manne BK Liverani E | 2014 | Thromb Haemost2014，111，3： | 1 |
| 18 | Prednisolone exerts ex- quisite inhibitory properties on platelet functions 显示文摘 | Liverani E Banerjee S Roberts W | 2012 | Biochem Pharmacol2012，83，10： | 1 |
| 19 | A CAD-augmented Reality Integrated Environment for Assembly Sequence Cheek and Interactive Validation 显示文摘 | Liverani A Amati G Caligiana G | 2004 | Concurrent Engineering: Research and Application (S1063-293X)2004，12，3： | 1 |
| 20 | Simple fabrication technique for muhilayered stratified composite scaffolds suitable for interface tissue engineering 显示文摘 | Liverani L Roether JA Nooeaid P | 2012 | Mater Sci Eng A Struct Mater2012，557，： | 1 |
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