|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 电针激活迷走神经-肾上腺轴的神经解剖学基础显示文摘电针刺激 (ES) 通过躯体感觉自主神经反射来调控机体的生理功能(如抑制严重的炎症)。二十世纪七十年代有学者认为针刺反射具有身体区域特异性(穴位特异性)。例如,低强度 (0.5 mA,10 Hz) ES 小鼠后肢穴位足三里 (ST36) 可激活迷走神经-肾上腺抗炎通路,而 ES 腹部天枢穴 (ST25) 无效,这种现象的神经解剖学基础尚不清楚。最近,在一项新的研究中,来自哈佛大学医学院、中国中医科学院和复旦大学的研究人员阐明了 ES 激活迷走神经-肾上腺轴抗炎通路的神经解剖学机制,并发现了由 PROKR2^(Cre)标记的感觉神经元对激活迷走神经-肾上腺轴至关重要。特异性敲除小鼠表达 PROKR2^(Cre)标记的 DRG 神经元,低强度电针 (0.5 mA) 刺激后肢 ST36 穴位不产生任何反应,不能使肾上腺释放儿茶酚胺类神经递质,也无法抑制细菌内毒素脂多糖 (LPS) 所诱发的全身炎症;而高强度电针 (3.0 mA)刺激后肢穴位 ST36 和腹部穴位 ST25 可激活交感神经抗炎通路。该研究还发现,进一步运用交叉遗传的方法特异性诱导光敏感通道蛋白 CatCh 表达于 PROKR2^(Cre)标记的神经末梢,可以激活迷走神经-肾上腺抗炎通路,但不能激活交感神经-肾上腺抗炎通路。此外,PROKR2^(Cre)神经纤维的分布可以预测低强度 ES 产生抗炎作用的身体区域(穴位特异性)。该研究为穴位选择和特异性激活自主神经通路提供了神经解剖学基础。尽管现代解剖学没有文献支持经络的物理存在,但针灸确实可以通过躯体神经反射来达到治疗效果。这些反射始于背根神经节 (DRG) 和/或三叉神经节周围神经的激活,然后从脊髓向大脑传递感觉信息,进而激活外周自主神经通路,最终对机体进行调控。该研究解读了为什么 ES 足三里 (ST36) 可激活迷走-肾上腺轴,而刺激腹部天枢穴 (ST25) 无任何效果,ES 刺激 ST25反而激活了脊髓交感神经通路。该研究认为迷走神经-肾上腺抗炎通道是由感觉神经介导,是后肢特有的 PROKR2^(Cre)标记的 DRG 神经元(一种 Cre 介导的重组标记神经元具有 PROKR2 持续或瞬时表达的作用)激活的,这些神经纤维密集分布在后肢深层筋膜组织。 | 陈紫悦(译) 韩清见(校) Liu SB Wang ZF Su YS | 2022 | 中国疼痛医学杂志2022，28，4： | 6 |
| 2 | Expression and anti-apoptotic mechanism of Spodoptera littoralis Nucleopolyhedrovirus P49 protein显示文摘A novel cloned Spodoptera littoralis Nucleo-polyhedrovirus (SINPV) p49 gene is able to suppress apop-tosis of insect cells Sf9 triggered by virus. The amino acid sequence of P49 expressed in baculovirus expression system is the same as predicted, indicating that the expression of P49 is correct. Metabolic labeling revealed that p49 was able to be expressed both in the early and late phases after the viral infection, and only in the late phase was the expression driven by polyhedra promoter, but the amount of expression was higher than that of wtSlNPV. In summary, the early gene of SINPV p49 as well as p35 of AcMNPV is able to be expressed in the late phase, but its promoter is weaker compared with polyhedra promoter. In vitro, P49 can be cut by Bm caspase and human caspase-3, yielding 10 and 40 ku fragments. Purified P49 blocks the substrate cleavage by Bm caspase and human caspase-3, showing that P49 inhibits downstream caspases in the apoptotic pathway. | Pei, ZF Qi, YP Liu, YL Xiao, HZ | 2002 | Chinese Science Bulletin2002，47，8： | 2 |
| 3 | Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS显示文摘 | Hao C Liu ZF Blum W | 2007 | J of Chromatography B2007，，850： | 1 |
| 4 | Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice 显示文摘 | Dong YF Liu L Lai ZF | 2010 | J Hyper- tens2010，28，7： | 1 |
| 5 | mmobilizing shortened single walled carbon nanotubes (SWNTs) on gold using a surface condensation method显示文摘 | Nan XL Gu ZN Liu ZF | 2002 | Journal of Colloid and Interface SeienceJ2002，245，2： | 1 |
| 6 | Urinary metabonomie study using a CUMS rat model of depression显示文摘 | Liu X J Li ZY Li ZF | 2012 | Magn Reson Chem2012，50，3： | 1 |
| 7 | Endoscopic surgery for hypertensive cerebral hemorrhage 显示文摘 | Wang ZF Liu F Liao DG | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban2005，30，4： | 1 |
| 8 | Celecoxib regulates apoptosis and autophagy via the PI3K/Akt signaling pathway in SGC-7901 gastric cancer cells显示文摘 | Liu M Li CM Chen ZF | 2014 | Int J Mol Med2014，33，6： | 1 |
| 9 | Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy 显示文摘 | Zhou F He MM Liu ZF Zhang L | 2013 | Placenta2013，34，5： | 1 |
| 10 | Resonance Rayleigh scattering spectra for studying the interaction of heparin with some basic phenothiazine dyes and their analytical applications显示文摘 | Luo HQ Liu SP Liu ZF | 2001 | Anal Chim Acta2001，449，12： | 1 |
| 11 | Effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxia-reoxygenation induced myocardial injury显示文摘 | Liu ZF Yang H | 2000 | Acta Pharmacol Sin2000，21，： | 1 |
| 12 | A serum proteomic pattern for the detection of colorectal adenocareinoma using surface enhanced laser desorption and ionization mass spectrometry显示文摘 | Liu XP Shen J Li ZF | 2006 | Cancer Invest2006，24，8： | 1 |
| 13 | -asaroue attenuates ischemia-reper- fusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclinl 显示文摘 | Liu L Fang YQ Xue ZF | 2012 | Eur J Pharmacol2012，680，13： | 1 |
| 14 | Determination of polybrominated diphenyl ethers in human semen 显示文摘 | Liu PY Zhao YX Zhu YY Qin ZF Ruan XL Zhang YC Chen B J Li Y Yan SS Qin XF Fu S Xu XB | 2012 | Environ Int2012，，42： | 1 |
| 15 | Small interfering RNA- mediated sileneing of heat shock protein 27 (HSP27) increases chemosensitivity to paelitaxel by increasing production of reactive oxygen species in human ovarian cancer cells(HO8910)显示文摘 | Song TF Zhang ZF Liu L | 2009 | J Int MedRes2009，37，5： | 1 |
| 16 | Role of AC-cAMP-PKA Cascade in Antidepressant Actionof Electroacupuncture Treatment in Rats显示文摘 | Liu JH Wu ZF Sun J | | 0，，： | 1 |
| 17 | Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate显示文摘 | Shi S Bao ZF Liu Y | 2016 | Int Endod J2016，49，2： | 1 |
| 18 | Purification and properties of a novel insecticidal protein from the locust pathogen Serratia marcescens HR-3显示文摘 | Tao K Long ZF Liu K | 2006 | Curr Microbiol2006，52，1： | 1 |
| 19 | Effects of antidigoxin antiserum on endoxin levels,apoptosis and the expression of Bax and Bcl-2 protein in ischaemia-reperfusion myocardium显示文摘 | Ke YS Liu ZF Wang DG | 2004 | Clin Exp Pharmacol Physiol2004，31，： | 1 |
| 20 | A meta-analysis of the value of fluorodeoxyglucose-PET/PET-CT in the evaluation of fever of unknown origin显示文摘 | Dong MJ Zhao K Liu ZF | | 0，，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员