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| 1 | A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine显示文摘AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal injection.Theexpression and distribution of the plasmid wereobserved at different time periods by in situhybridization and immunohistochemistry.RESULTS The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and intraperitonealroutes.One week later the expression began todecrease,and could still be observed three weekslater.Although both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the latter.CONCLUSION Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route. | Yang CQ Wang JY Fang GT Liu JJ Guo JS | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 2 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Late morbidity associated with a tumour -negative sentinel lymph node biopsy in primary breast cancer pa- tients: a systematic review显示文摘 | Liu CQ Guo Y Shi JY | 2009 | Eur J Cancer2009，45，45： | 1 |
| 4 | Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation显示文摘 | Chen H Liu J Zhao CQ | 2001 | Toxicol Appl Pharmacol2001，175，： | 1 |
| 5 | A modified percutaneous transhepatic variceal embolization with 2-Octyl cyanoacrylate versus endoscopic ligation in esophageal variceal bleeding management:randomized controlled trial显示文摘 | Zhang CQ Liu FL Liang B | | 0，，08： | 1 |
| 6 | Characteristics of stem cells derived from the degenerated human intervertebral disc cartilage endplate显示文摘 | Liu LT Huang B Li CQ | 2011 | PLoS One2011，6，26： | 1 |
| 7 | Possible mechanisms of the protectionof ginsenoside Re against MPTP-induced apoptosis in substantianigra neurons of Parkinson's disease mouse model显示文摘 | XuBB Liu CQ Gao X | 2005 | J Asian NatProd Res2005，7，3： | 1 |
| 8 | Differentiation of rat bone marrow stromal ceils into neuron like cells 显示文摘 | LI CQ LIU D WU XQ | 2004 | Zhong Nan Da Xue Xue Bao Yi Xue Ban2004，29，1： | 1 |
| 9 | Study to determine the presence of progenitor ceils in the degenerated human cartilage endplates显示文摘 | Huang B Liu LT Li CQ | 2012 | Eur Spine J2012，21，4： | 1 |
| 10 | Development of food-grade cloning and expression vectors for Lactococcus lac-tis显示文摘 | Liu CQ Su P Khunajakr N | 2005 | Journal of Applied Microbiology2005，98，： | 1 |
| 11 | Simple and sensitive assay for nucleic acids by use of Rayleigh light scattering technique with rhodamine B显示文摘 | Liu Y Lie KA Tong SY Ma CQ | 1999 | Analytica Chimica Acta1999，379，12： | 1 |
| 12 | Subtotal colectomy with antiperi-staltic cecoproctostomy for selected patients with slow-transit con-stipation显示文摘 | Jiang CQ Qian Q Liu ZS et a1 | 2008 | Int J Colorectal Dis2008，12，12： | 1 |
| 13 | Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson' s disease mouse model显示文摘 | Xu BB Liu CQ Gao X | 2005 | Journal of Asian Natural Products Research2005，7，： | 1 |
| 14 | Association of a genetic vari ant in the apolipoprotein A5 gene with the metabolic syn- drome in Chinese 显示文摘 | Ong KL Jiang CQ Liu B | 2011 | Clin Endocrinol ( Oxf)2011，74，2： | 1 |
| 15 | Effect of inhaled Interleukin 5 on airway hyperreactivity and cosi- nophilia in asthmatics显示文摘 | Shi HZ Xiao CQ Zhong D Qin SM Liu Y Liang GR | 1998 | Am J Respir Crit Care Med1998，157，： | 1 |
| 16 | Neonatal in-fections in Asia显示文摘 | Tiskumara R Fakharee SH Liu CQ | 2009 | Arch Dis Child FetaJ Neonatal Ed2009，94，2： | 1 |
| 17 | Interleukin-lbeta enhances the effect of serum deprivation on rat annular cell apoptosis 显示文摘 | Zhao CQ Liu D Li H | 2007 | Apoptosis2007，12，12： | 1 |
| 18 | Seasonal variation and source apportionment of PAHs in TSP in the atmosphere of Guiyang, Southwest China显示文摘 | HU J LIU CQ ZHANG G P | 2012 | Atmospheric Research2012，118，： | 1 |
| 19 | Neonatal infec-tions in Asia 显示文摘 | Tiskumara R Fakharee SH Liu CQ | 2009 | Arch Dis Child Fetal Neonatal Ed2009，94，2： | 1 |
| 20 | Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway 显示文摘 | Xu CQ Liu BJ Wu JF | 2010 | Eur J Pharmacol2010，642，13： | 1 |
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