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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Synthesis and characterisation of day-supported titania photocatalysts显示文摘 | Lisa M D Ray L F Huai Y Z | | 0，，： | 1 |
| 3 | A Real-time Hulti-agent System Archltecture for E-commerce Applications显示文摘 | Lisa C D Victor F W LekshmiN | 2000 | Computer StandardS & Interfaces2000，，22： | 1 |
| 4 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 5 | Extracellular superoxide dismutase in biology and medicine 显示文摘 | Cheryl L F Lisa M S Tim D O | 2003 | Free Rad Biol Med2003，35，3： | 1 |
| 6 | Identification of a novel cleavage activity of the first papain-like proteinase domain encoded by open reading frame 1a of the coronavirus avian infectious bronchitis virus and characterization of the cleavage products显示文摘 | Lim K P Lisa F P Liu D X | | J Virolo0，，： | 1 |
| 7 | Identification of a 24kD polypeptide processed from the coronavirus infectious bronchitis virus 1a polyprotein by the 3c-like proteinase and determination of its cleavage sites显示文摘 | Lisa F P Liu D X | 1998 | Virology1998，243，： | 1 |
| 8 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
| 9 | Mhpl07 is a member of the muhifunctional adhesion family of Mycoplasma hyopneumoniae 显示文摘 | LISA M S LINDA F ANIA T D | 2011 | J Biol Chem2011，286，10： | 1 |
| 10 | Mhpl07 is a member of the muhifunctional adhesin family of Mycoplasma hyopneu- moniae显示文摘 | Lisa M S Linda F Ania T D | 2011 | The American Society for Biochemistry and Mo- lecular Biology2011，286，10： | 1 |
| 11 | Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation显示文摘 | Lisa F D Tullio R D Salamino F | 1995 | Biochemical Journal1995，308，02646021： | 1 |
| 12 | American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer显示文摘 | Hammond M Elizabeth H Hayes Daniel F Dowsett Mitch Allred D Craig Hagerty Karen L Badve Sunil Fitzgibbons Patrick L Francis Glenn Goldstein Neil S Hayes Malcolm Hicks David G Lester Susan Love Richard Mangu Pamela B McShane Lisa Miller Kei | 2010 | Archives of Pathology & Laboratory Medicine2010，，6： | 1 |
| 13 | A Real- Time Multi- Agent System Architecture for E-Commerce Applications 显示文摘 | Lisa C D Victor F W Lekshmi N Ethan H Oleg U | 2000 | Computer Standards & Interfaces2000，，22： | 1 |
| 14 | Practical asymmet- ric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor显示文摘 | Chen C Y Richard D T Lisa F | 1998 | The Journal of Organic Chemisty1998，63，23： | 1 |
| 15 | Relations of plasma homocysteine to left ventricular structure and tunction : the Framingham Heart Study 显示文摘 | Johan Sundstrom Sullivan Lisa Selhub Jacob Benjamin EmeliaJ D'agostirto Ralph B Jacques Paul F Roseberg h'win H Levy Daniel Wilson Peter Wf Vasan Ramachandran S | 2004 | Europ Heart J2004，25，6： | 1 |
| 16 | Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease显示文摘 | Craig D F Andrew J L Lisa M A | 2009 | Drug Metab Dispos2009，37，： | 1 |
| 17 | Extracellular superoxide dismutase in biology and medicine显示文摘 | CHERYL L F LISA M S TIM D 0 | 2003 | Free Rad Biol Med2003，35，3： | 1 |
| 18 | High-reso- lution characterization of linkage disequilibrium struc- Lure and selection of tagging single nucleotide poly- norphisms : application to the CholesteryI Ester trans- Fer protein gene显示文摘 | Benjamin D H John F C Lisa A C | 2006 | Annals of Human Genetics2006，70，4： | 1 |
| 19 | Feeding aquaculture growth through globalization: exploitation of marine ecosystems for fish meal显示文摘 | LISA D SARA G CARL F | 2007 | Global Environmental Change2007，17，2： | 1 |
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