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| 1 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 2 | Results of internal fixation of Pauwels type-3 vertical femoral neck fractures显示文摘 | Liporace F Gaines R Collinge C et al | 2008 | J Bone Joint Surg Am2008，90，8： | 1 |
| 3 | Results of inter- nal fixation of Pauwels type-3 vertical femoral neck fractures显示文摘 | LIPORACE F GAINES R COLINGE C | 2008 | J Bone Joint Surg Am2008，90，8： | 1 |
| 4 | Frequency ofcatamenial seizure exacerbation in women with localization-re-lated epilepsy显示文摘 | Herzog A G Harden C L Liporace J | 2004 | Ann Neurol2004，56，3： | 1 |
| 5 | Results of internal fixation of Pauwels type-3 vertical femoral neck fractures 显示文摘 | Liporace F Gaines R Collinge C | 2008 | J Bone Joint Surg Am2008，90，8： | 1 |
| 6 | Functional outcome fol- lowing one-part proximal humeral fractures: A prospective study 显示文摘 | Tejwani NC Liporace F Walsh M | 2008 | J Shoulder elbow Surg2008，17，2： | 1 |
| 7 | Results of internal fixation of Pauwls type -3 vertical femoral neck fractures显示文摘 | Liporace Gaines R Collinge C | 2008 | J Bone Joint Surg Am2008，90，： | 1 |
| 8 | An adjunct to percutaneous plate insertion to obtain optimal sagittal plane alignment in the treatment of pilon fractures显示文摘 | Liporace FA Yoon RS | 2012 | The Journal of Foot and An- kle Surgery:Official Publication of The American College of Foot and Ankle Surgeons2012，51，2： | 1 |
| 9 | Results of internal fixation of Pauwels type-3 vertical femoral neck fractures显示文摘 | Liporace F Gaines R Collinge C | 2008 | J Bone Joint Surg Am2008，90，8： | 1 |
| 10 | Pelvic Fractures: Part 1. Evaluation, Classification, and Resuscitation显示文摘 | Joshua R. Langford Andrew R. Burgess Frank A. Liporace George J. Haidukewych | 2013 | Journal of the American Academy of Orthopaedic Surgeons2013，，8： | 1 |
| 11 | Decisions and staging leading to definitive open management of pilon fractures:Where have we come from and where are we now?显示文摘 | Liporace FA Yoon RS | 2012 | Journal of Orthopaedic Trauma2012，26，8： | 1 |
| 12 | Concerns regarding lamotrigine and breast-feeding显示文摘 | Liporace J Kao A D'Abreu A | 2004 | Epilepsy Behav2004，5，1： | 1 |
| 13 | Absence sei zures and carbamazeplne in adults显示文摘 | Liporace J D Sperling M R Dichter M A | 1994 | Epilepsia1994，35，5： | 1 |
| 14 | Maximum likelihood estimation for multirate observation of Markov sources 显示文摘 | liporace LA | 1986 | IT-32(2):307-3091986，32，2： | 1 |
| 15 | What' s new in hip frac- tures? Current concepts 显示文摘 | Liporace FA Egol KA Tejwani N | 2005 | Am J Orthop (Belle Mead NJ )2005，34，2： | 1 |
| 16 | An evaluation of two scoring systems to predict instability in fractures of the distal radius显示文摘 | JEONG G KAPLAN T LIPORACE F | 2003 | J Trauma2003，57，： | 1 |
| 17 | Results of internal fixation ofPauwels type - 3 vertical femoral neck fractures 显示文摘 | Liporace F Gaines R Collinge C t | 2008 | J Bone JointSurg Am2008，8，： | 1 |
| 18 | Distal radius fractures 显示文摘 | Liporace FA Adams MR Capo JT | 2009 | J Orthop Trauma2009，23，10： | 1 |
| 19 | Frequency of catamenial seizure exacerbation in women with localization-related epilepsy 显示文摘 | Herzog AG Harden CL Liporace J | 2004 | Ann Neurol2004，56，3： | 1 |
| 20 | Results of internal fixation of Pauwels type - 3 vertical femoral neck fractures 显示文摘 | Liporace F Gaines R Collinge C | 2008 | J Bone Joint Surg Am2008，90，： | 1 |
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