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| 1 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 4 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019，2，1： | 2 |
| 5 | Text mining as a valuable tool in foresight exercises:A study on nanotechnology显示文摘 | MARCIO de MIRANDA SANTO GILDA MASSARI COELHO DALCI MARIA dos SANTOS LéLIO FELLOWS FILHO | 2006 | Technological Forecasting & Social Change2006，73，： | 1 |
| 6 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite显示文摘 | Mcallister M J Lio J L Adamson D H | 2007 | Chem Mater2007，19，18： | 1 |
| 7 | Virtual binocular vision systems to solid model reconstruction显示文摘 | CHEN C L TAI C L LIO Y F | 2007 | The Internation- al Journal of Advanced Manufacturing Technology2007，，35： | 1 |
| 8 | Parameter Estimations for Generalized Exponential Distribution under Progressive Typo-I Interval Censoring 显示文摘 | Chen D G Lio Y L | 2010 | Computational Statistics and Data Analysis2010，，54： | 1 |
| 9 | Inflammation, genetics, and longevity: further studies on the pro- tective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP 显示文摘 | Lio D Scola L Crivello A | 2003 | J Med Genet2003，40，4： | 1 |
| 10 | One Step Synthesis of Dipyrromethanes in Water显示文摘 | Abílio J F N Nuno G C L | 2003 | Tetrahedron Letters2003，44，20： | 1 |
| 11 | Immediate free flap reconstruction for advanced-stage breast cancer:Is it safe显示文摘 | CRISERA C A CHANG E I DA LIO A L | | 0，，01： | 1 |
| 12 | Visual binocular vision systems to solid model reconstruction 显示文摘 | CHEN C L TAI C L LIO Y F | 2007 | The International Jourhal of Advanced Manufacturing Technology2007，35，34： | 1 |
| 13 | Oral colon - specific drug delivery for bee venom peptide: development of a coatde calcium alginate gel beads- entrapped liposome 显示文摘 | Xing L Dawei C Lioing X | 2003 | Control Relerse2003，93，3： | 1 |
| 14 | Virtual binocular vision systems to solid model reconstruction显示文摘 | CHEN C L TAI C L LIO Y F | 2007 | The International Journal of Advanced Manufacturing Technology2007，35，34： | 1 |
| 15 | Spontaneous Phase and Morphology Transformations of Anodized Titania Nanotubes Induced by Water at Room Temperature 显示文摘 | Wang D Lio L Zhang F Tao K Pippel E Domen K | 2011 | Nano letters2011，11，9： | 1 |
| 16 | 查看详情显示文摘 | Ildo L S H&lio Tatizawa Francisco A M | | 0，，： | 1 |
| 17 | Virtual binocular vision sys- tems to solid model reconstruction 显示文摘 | CHEN C L TAI C L LIO Y F | 2007 | The International Journal of Advanced Manufacturing Technology2007，35，34： | 1 |
| 18 | Single sheet functionalized grapheneby oxidation and thermal expansion of graphite 显示文摘 | Mcallister M J Lio J L Adamsond H | 2007 | Chemistry of Materials2007，19，18： | 1 |
| 19 | Immediate placement of implants in breast reconstruction: patient selection and out- comes显示文摘 | Roostaeian J Pavone L Da Lio A | 2011 | Plast Reconstr Surg2011，127，4： | 1 |
| 20 | Mass flow rate measurements in gas-liquid flows by means of a venturi or orifice plate coupled to a void fraction sensor显示文摘 | JORGE L G O JúLIO C P RUUD V | | 0，，： | 1 |
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