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| 1 | Error suppression techniques for energy-efficient high-resolution SAR ADCs显示文摘The successive approximation register(SAR)is one of the most energy-efficient analog-to-digital converter(ADC)architecture for medium-resolution applications.However,its high energy efficiency quickly diminishes when the target resolution increases.This is because a SAR ADC suffers from several major error source,including the sampling kT/C noise,the comparator noise,and the DAC mismatch.These errors are increasing hard to address in high-resolution SAR ADCs.This paper reviews recent advances on error suppression techniques for SAR ADCs,including the sampling kT/C noise reduction,the noise-shaping(NS)SAR,and the mismatch error shaping(MES).These techniques aim to boost the resolution of SAR ADCs while maintaining their superior energy efficiency. | Jiaxin Liu Xiyuan Tang Linxiao Shen Shaolan Li Zhelu Li Wenjuan Guo Nan Sun | 2020 | Journal of Semiconductors2020，41，11： | 2 |
| 2 | Modification of cell wall polysaccharide during ripening of Chinese bayberry fruit显示文摘 | Xuke Sun Qin Yang Weidong Guo Linxiao Dai Wenrong Chen | 2013 | Scientia Horticulturae2013，，： | 1 |
| 3 | Reinventing MoS2 Co-catalytic Fenton reaction:Oxygen-incorporation mediating surface superoxide radical generation显示文摘To better understand the mechanisms of hydrogen peroxide(H_(2)O_(2))’s decomposition and reactive oxygen species(ROS)’s formation on the catalyst’s surface is always a critical issue for the environmental application of Fenton/Fenton-like reaction.We here report a new approach to activate H_(2)O_(2) in a co-catalytic Fenton system with oxygen incorporated MoS2,namely MoS_(2−x) O_(x) nanosheets.The MoS_(2−x) O_(x) nanosheets assisted co-catalytic Fenton system exhibited superior degradation activity of emerging antibiotic contaminants(e.g.,sulfamethoxazole).Combining density functional theory(DFT)calculation and experimental investigation,we demonstrated that oxygen incorporation could improve the intrinsic conductivity of MoS_(2−x) O_(x) nanosheets and accelerate surface/interfacial charge transfer,which further leads to the efficacious activation of H_(2)O_(2).Moreover,by tuning the oxygen proportion in MoS_(2−x) O_(x) nanosheets,we are able to modulate the generation of ROS and further direct the oriented-conversion of H_(2)O_(2) to surface-bounded superoxide radical(·O_(2−surface)).It sheds light on the generation and transformation of ROS in the engineered system(e.g.,Fenton,Fenton-like reaction)for efficient degradation of persistent pollutants. | Xianjun Tan Wenhui Ding Zhenying Jiang Linxiao Sun Yuxiong Huang | 2022 | Nano Research2022，15，3： | 1 |
| 4 | Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy显示文摘Ferroptosis is a new mode of cell death,which can be induced by Fenton reactionmediated lipid peroxidation.However,the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ferroptosis.Herein,a self-supplying lipid peroxide nanoreactor was developed to co-delivery of doxorubicin(DOX),iron and unsaturated lipid for efficient ferroptosis.By leveraging the coordination effect between DOX and Fe3+,trisulfide bond-bridged DOX dimeric prodrug was actively loaded into the core of the unsaturated lipids-rich liposome via iron ion gradient method.First,Fe3+could react with the overexpressed GSH in tumor cells,inducing the GSH depletion and Fe2+generation.Second,the cleavage of trisulfide bond could also consume GSH,and the released DOX induces the generation of H2O2,which would react with the generated Fe2+in step one to induce efficient Fenton reaction-dependent ferroptosis.Third,the formed Fe3+/Fe2+couple could directly catalyze peroxidation of unsaturated lipids to boost Fenton reaction-independent ferroptosis.This iron-prodrug liposome nanoreactor precisely programs multimodal ferroptosis by integrating GSH depletion,ROS generation and lipid peroxidation,providing new sights for efficient cancer therapy. | Yinxian Yang Shiyi Zuo Linxiao Li Xiao Kuang Jinbo Li Bingjun Sun Shujun Wang Zhonggui He Jin Sun | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 5 | Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation显示文摘Primary hepatocytes(PHCs)are widely used in various fields,but the progressive deterioration of liverspecific features in vitro significantly limits their application.While the transcriptional regulation and whole cell proteome(WCP)of PHCs have been extensively studied,only a small number of studies have addressed the role of posttranslational modifications in this process.To elucidate the underlying mechanisms that induce dedifferentiation,we carried out parallel quantifications of the transcriptome,WCP,ubiquitinome,and phosphoproteome of rat PHCs after 0,6,12,24,and 48 h of in vitro culture.Our data constitute a detailed proteomic analysis of dedifferentiated PHCs including 2196 proteins,2056 ubiquitinated sites,and 4932 phosphorylated peptides.We revealed a low correlation between the transcriptome and WCP during dedifferentiation.A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiation of PHCs led to an increase in nondegradative K27 ubiquitination.Functional analysis of the altered phosphoproteins suggested a significant enrichment in ferroptosis.In all,404 proteins with both ubiquitination and phosphorylation were identified to be involved in critical metabolic events.Furthermore,Ptbph Hnqjd,Hnrnpu,and Srrm2 were identified as hub genes.Taken together,our data provide new insights into proteome dynamics during PHC dedifferentiation and potential targets to inhibit the dedifferentiation process. | Zhengyi Jiang Zeyu Sun Xiaoxi Ouyang Yalei Zhao Menghao Zhou Baohong Wang Qirui Li Linxiao Fan Sainan Zhang Lanjuan Li | 2020 | Engineering2020，6，11： | 0 |
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