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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Learning deficit in BDNF mutant mice显示文摘 | Linnarsson S Bjorklund A Ernfors P | 1997 | European J Neurosci1997，9，12： | 1 |
| 3 | Learning deficit in BDNF mutant mice显示文摘 | Linnarsson S Bjorklund A Emfors P | 1997 | Eur J Neurosci1997，9，： | 1 |
| 4 | Effects of an at- tiflcial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-tem, bed rest 显示文摘 | Linnarsson D Hughson RL Fraser KS | 2015 | Journal of Applied Physiology2015，118，1： | 1 |
| 5 | Learning deficit in BDNF mutant mice显示文摘 | Linnarsson S Bjorklund A Ernfors P | 1997 | EurJ Neurosci1997，9，： | 1 |
| 6 | BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex 显示文摘 | Ringstedt T Linnarsson S Wagner J | 1998 | Neuron1998，21，： | 1 |
| 7 | 查看详情显示文摘 | Schleussner S M T¨orndah T Linnarsson M Zimmermann U W¨atjen T Edoff M | | 0，，： | 1 |
| 8 | Single-cell sequencing-based technologies will revolutionize whole-organism science显示文摘 | Shapiro E Biezuner T Linnarsson S | 2013 | Nature Reviews Genetics2013，14，9： | 1 |
| 9 | Toxicity of lunar dust 显示文摘 | Linnarsson D Carpenter J Fubini B | 2012 | Planet Space Sci2012，74，1： | 1 |
| 10 | BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex 显示文摘 | Ringstedt T Linnarsson S Wagner J | 1998 | Neuron1998，21，2： | 1 |
| 11 | Cell death in regenerating populations of neurons in BDNF mutant mice显示文摘 | Linnarsson S winson CA Ernfors P | 2000 | Brain Res Mol Brain Res2000，75，： | 1 |
| 12 | Cell death in regenerating populations of neurons in BDNF mutant mice显示文摘 | Linnarsson S Willson C A Ernfors P | 2000 | Brain Res Mol Brain Res2000，75，： | 1 |
| 13 | Autonomic origin of heart rate fluctuations at the onset of muscular exercise显示文摘 | Fagraeus L Linnarsson D | | 0，，05： | 1 |
| 14 | Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise 显示文摘 | Linnarsson D | 1974 | Acta Physiol Scand1974，415，1： | 1 |
| 15 | Overcoming the innovation-alli- ance paradox: A case study of an explorative alliance显示文摘 | Linnarsson H Werr A | 2004 | European Journal of Innovation Management2004，7，1： | 1 |
| 16 | Hyperbaric bradycardia and hypoventilation in exercising men: effects of ambient pressure and breathing gas 显示文摘 | Linnarsson D Ostlund A Lind F | 1999 | J Appl Physiol1999，87，4： | 1 |
| 17 | Relationships between diabetes duration,metabolic control and beta-cell function in a representative population of type 2 diabetic patients in Sweden显示文摘 | Clauson P Linnarsson R Gottsater A | | 0，，： | 1 |
| 18 | Cardiopulmonary readjustment during graded submersion in water at 35℃显示文摘 | Farhi LE Linnarsson D | 1977 | Respir Physiol1977，30，： | 1 |
| 19 | Lung function during and after prolonged headdown bed rest显示文摘 | Montmerle Ste phanie Jonas Spaak and Dag Linnarsson | 2002 | J Appl Physiol2002，92，： | 1 |
| 20 | Single-Cell sequencing-based technologies will revolutionize whole-organism science显示文摘 | Shapiro E Biezuner T Linnarsson S | | Nature Reviews Genetics0，14，9： | 1 |
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