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| 1 | A^200 ka pollen record from Okinawa Trough:Paleoenvironment reconstruction of glacial-interglacial cycles显示文摘Pollen analysis was carried out on the Core MD982194 of 29.78 m retrieved from the Middle Okinawa Trough which was dated as old as^200 ka BP.The results revealed that pollen assemblages mainly presented an alternation of coniferous and herb pollen.The coniferous saccate pollen,principally Pinus and Tsuga,predominated in most parts of the core,especially highlighted in the interstadial stages including MIS 1,3,5 and MIS7,whereas the herb pollen significantly increased in the glacial periods.Thus the pollen flora and their percentages showed the sensitive changes under the influence of ice volume during the glacial and interglacial periods.Our record from this core has first documented that the percentage of Cyperaceae was extremely high in the glacial stages with a notable increase in Artemisia,Gramineae,Asteraceae,Chenopodiaceae,and freshwater algae,which can be used as a proxy for sea-level change at the study site because of their close negative correlation of the orbital-scale changes in sea level.The distance between the continental coastline and the Okinawa Trough has deeply shortened due to the sea-level drop in the LGM.As a result,the sediment materials from Yangtze River were extensively deposited on the flat,exposed continental shelf owing to the rapid decline of river flow speed,leading to that pollen grains from Okinawa Trough are derived mainly from the flat coastal vegetation of exposed continental shelf at glacial stages.Changes of pollen assemblage were consistent with the variation of temperature and humidity,which showed that the percentage of arboreal pollen was highly augmented at MIS 7,5 and MIS 1,corresponding to the strengthening of the East Asian summer monsoon and increasing of rainfall.Moreover,the peak of Pinus percentage in MIS 5.3,5.1 and MIS 3.3 may be closely linked by orbital and sub-orbital cycles of solar radiation and monsoonal variability.The present study of core MD981294 implied lower temperature and precipitation during the lowest sea-level stage(LGM),and more visibly testified that the vegetation of the flat plain on the exposed continental shelf was dominated by intrazonal communities such as halophyte grasslands and freshwater wetlands instead of zonal steppe or semi-arid desert.All above evidence demonstrated that the fundamental changes of pollen assemblage and their origins in Okinawa Trough since^200 ka BP were affected by combine factors including the coastline position and climate fluctuation.Moreover,the substantial shortening of distance between shoreline and the Okinawa Trough driven by orbital insolation cycles was clearly indicated by the pollen spectra,whereas the source-area climate signal of the pollen record was largely weakened. | ZHENG Zhuo HUANG KangYou DENG Yun CAO LingLong YU ShaoHua Jean-Pierre SUC Serge BERNE Franois GUICHARD | 2013 | Science China Earth Sciences2013，56，10： | 11 |
| 2 | Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo显示文摘With the understanding of microRNA(miRNA or miR) functions in tumor initiation,progression,and metastasis,efforts are underway to develop new miRNA-based therapies.Very recently,we demonstrated effectiveness of a novel humanized bioengineered miR-124-3 p prodrug in controlling spontaneous lung metastasis in mouse models.This study was to investigate the molecular and cellular mechanisms by which miR-124-3 p controls tumor metastasis.Proteomics study identified a set of proteins selectively and significantly downregulated by bioengineered miR-124-3 p in A549 cells,which were assembled into multiple cellular components critical for metastatic potential.Among them,plectin(PLEC) was verified as a new direct target for miR-124-3 p that links cytoskeleton components and junctions.In miR-124-3 p-treated lung cancer and osteosarcoma cells,protein levels of vimentin,talin 1(TLN1),integrin beta-1(ITGB1),IQ motif containing GTPase activating protein 1(IQGAP1),cadherin2 or N-cadherin(CDH2),and junctional adhesion molecule A(F11 R or JAMA or JAM1) decreased,causing remodeling of cytoskeletons and disruption of cell-cell junctions.Furthermore,miR-124-3 p sharply suppressed the formation of focal adhesion plaques,leading to reduced cell adhesion capacity.Additionally,efficacy and safety of biologic miR-124-3 p therapy was established in an aggressive experimental metastasis mouse model in vivo.These results connect miR-124-3 p-PLEC signaling to other elements in the control of cytoskeleton,cell junctions,and adhesion essential for cancer cell invasion and extravasation towards metastasis,and support the promise of miR-124 therapy. | Linglong Deng Hannah Petrek Mei-Juan Tu Neelu Batra Ai-Xi Yu Ai-Ming Yu | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 2 |
| 3 | Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica Sinica B 11 (2021) 3950e3965]显示文摘The authors regret that there was one incorrect image used within Fig.4A,143B cells treated with LSA at 24 h time point,which was obtained from vehicle group but mislabelled as LSA in the publication.In our studies,three biological replicates were included in each treatment group and at least three images were taken for different fields of each sample.We thus selected a correct representative image from the LSA treated 143B cells at 24 h time point to replace that mislabelled image,and the updated Fig.4 is provided below.The authors apologize for any inconvenience caused to the journal and readers,while this correction does not affect any results and conclusions.The authors have provided the original data of this figure to Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access. | Linglong Deng Hannah Petrek Mei-Juan Tu Neelu Batra Ai-Xi Yu Ai-Ming Yu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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