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| 1 | The boundary layer characteristics in the heavy fog formation process over Beijing and its adjacent areas显示文摘By utilizing the Atmospheric Boundary Layer (ABL) observational data made available from the project '973' under the auspices of the Ministry of Science and Technology of the People's Republic of China - entitled the Beijing City Air Pollution Observation Field Experiment (BECAPEX), including the measurements by a wind profiler, captive airships, tower-based boundary layer wind and temperature gradient observational instruments (ultrasonic anemometers and electronic thermometers), air composition samplers, conventional upper-air, surface and Automatic Weather Stations (AWS) observations, this paper herewith analyzes, in a comprehensive manner, the occurrence of a heavy fog event over Beijing in February 2001, including its formation, development, persistence, dynamic and thermodynamic features as well as evolving stratification structures within the boundary layer at different stages. The results suggested: (i) as a typical case of urban heavy fog, before the fog onset over Beijing, a temperature inversion existed in the lower atmosphere, the smokes and the pollutants like SO2 and NO2 had been accumulated at a lower level. Proceeding the fog event, with the increase of SO2 and NO2 concentrations, condensability increased sharply. On the contrary, during the fog process, with increasing condensability, SO2 and NO2 concentrations decreased. This indicated that, acting as condensation nucleus, these accumulated pollutants were playing a key role in catalyzing the fog condensation. (ii) By analyzing mean gradient-, pulsation- and turbulence-distribution patterns derived from the wind measurements taken by the aforementioned tower-based instruments, they all indicated that about 10 hours before the fog onset, a signal foretelling potential strong disturbances in the lower boundary layer was detected, and a significant rise of both mean and disturbance kinetic energies was observed, revealing that the low-level wind shear was strengthened before the fog onset, consequently creating a favorable condition for the outbreak of turbulences. This strong signal seemed to be very meaningful in monitoring and predicting fog occurrence and its development. (iii) Once the fog was in shape, its condensation feedback effects tended to lift the height of temperature inversion layer within the mid and upper levels of the lower atmosphere, which in return determined the fog persistence and restructuring process. | ZHANG Guangzhi, BIAN Lingeng, WANG Jizhi, YANG Yuanqin, YAO Wenqing & XU Xiangde HWL of Chinese Academy of Meteorological Sciences, Beijing 10008, China National Meteorological Center, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 12 |
| 2 | Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based cancer registries显示文摘Background:Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)are the most common subtypes of primary liver cancer,but nationwide incidence of both liver cancer subtypes have never been reported in China.We aimed to estimate the most recent incidence of HCC and ICC and temporal trends in China based on the most updated data from high qualified population-based cancer registries(covering 13.1%of the national population),in comparison to those in the United States at the same period.Methods:We used data from 188 Chinese population-based cancer registries covering 180.6 million population of China to estimate the nationwide incidence of HCC and ICC in 2015.And 22 population-based cancer registries’data were used to estimate the trends of HCC and ICC incidence from 2006 to 2015.Multiple imputation by chained equations method was used to impute liver cancer cases with unknown subtype(50.8%).We used data from 18 population-based registries from the Surveillance,Epidemiology,and End Results program to analyze incidence of HCC and ICC in the United States.Results:In China,an estimated 301,500 and 61,900 newly diagnosed HCC and ICC occurred in 2015.The overall age-standardized rates(ASRs)of HCC incidence decreased by 3.9%per year.For ICC incidence,the overall ASR was relatively stable,but increased in the population of over 65 years old.Subgroup analysis by age showed that the ASR of HCC incidence had the sharpest decline in population who were less than 14 years old and received neonatally hepatitis B virus(HBV)vaccination.In the United States,though the incidence of HCC and ICC were lower than those in China,the overall HCC and ICC incidence increased by 3.3%and 9.2%per year.Conclusions:China still faces with a heavy burden of liver cancer incidence.Our results may further support the beneficial effect of Hepatitis B vaccination on reduction of HCC incidence.Both healthy lifestyle promotion and infection control are needed for future liver cancer control and prevention for China and the United States. | Lan An Rongshou Zheng Siwei Zhang Ru Chen Shaoming Wang Kexin Sun Lingeng Lu Xuehong Zhang Hong Zhao Hongmei Zeng Wenqiang Wei Jie He | 2023 | Hepatobiliary Surgery and Nutrition2023，12，1： | 4 |
| 3 | The relationship of insulin- like growth factor-2, insulin like growth factor binding protein-3, and estrogen receptor-π expression to disease progression in epithelial ovarian cancer显示文摘 | Lingeng lu Dionyssios Katsaros | 2006 | Clin Cancer Res2006，12，4： | 1 |
| 4 | Pluripotent factor lin - 28 and its homologue lin -28b in epithelial ovarian cancer and their associa- tions with disease outcomes and expression of let - 7a and IGF - II显示文摘 | Lingeng Lu Dionyssios Katsaros | 2009 | Euro J Cancer2009，45，12： | 1 |
| 5 | IGF-I in epithelial ovarian cancer and its role in disease progression显示文摘 | Jane Brokaw Dionyssios Katsaros Andrew Wiley Lingeng Lu Dan Su Olga Sochirca Irene A. Rigault de la Longrais Susan Mayne Harvey Risch Herbert Yu | 2007 | Growth Factors2007，，5： | 1 |
| 6 | Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer显示文摘 | Lingeng Lu Guangjian Zhu Chong Zhang Qian Deng Dionyssios Katsaros Susan T. Mayne Harvey A. Risch Lina Mu Emilie Marion Canuto Gianluca Gregori Chiara Benedetto Herbert Yu | 2012 | Breast Cancer Research and Treatment2012，，3： | 1 |
| 7 | Hypermethylation of let-Ta-3 in epithelial ovaria cancer Is associated with low insulin-like growth favtor-Ⅱ expression and favorable prognosis 显示文摘 | Lingeng I Dionyssios K Irene A | 2007 | Cancer Res2007，67，10： | 1 |
| 8 | MicroRNA let-7a: A potential marker for selection of paclitaxel in ovarian cancer management显示文摘 | Lingeng Lu Peter Schwartz Luca Scarampi Thomas Rutherford Emilie Marion Canuto Herbert Yu Dionyssios Katsaros | 2011 | Gynecologic Oncology2011，，2： | 1 |
| 9 | Hypermethyla- tion of let-Ta-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favor-able prognosis显示文摘 | Lingeng Lu Dionyssios Katsaros Irene A | 2007 | Cancer Res2007，67，10： | 1 |
| 10 | Peptide concentrations and mRNA expression of IGF-I, IGF-II and IGFBP-3 in breast cancer and their associations with disease characteristics显示文摘 | Lina Mu Dionyssios Katsaros Andrew Wiley Lingeng Lu Irene A. Rigault Longrais Stephanie Smith Sapna Khubchandani Olga Sochirca Riccardo Arisio Herbert Yu | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
| 11 | High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1显示文摘 | Biyun Qian Dionyssios Katsaros Lingeng Lu Mario Preti Antonio Durando Riccardo Arisio Lina Mu Herbert Yu | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
| 12 | Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II显示文摘 | Lingeng Lu Dionyssios Katsaros Khvaramze Shaverdashvili Biyun Qian Yixing Wu Irene A. Rigault de la Longrais Mario Preti Guido Menato Herbert Yu | 2009 | European Journal of Cancer2009，，12： | 1 |
| 13 | DMT1 overexpression exacerbates Aβoligomer-induced cell damage显示文摘This study aims to reveal the role of metal ion transporter DMT1 in neurotoxicity induced by Aβ142 oligomers.We exposed SH-SY5Y cells(S-DMT1)stably overexpressing the DMT1 gene and SH-SY5Y cells(SGFP)overexpressing empty green fluorescent protein to AB.42 oligomers.CCK8 and Hoechst 33258 were used to detect the cell death rate and apoptotic rate.W estern blotting was used to detect the levels of apoptotic proteins caspase-3,Bax and Bcl-2.The results of CCK8 experiments showed that compared with SGFP cells,the number of viable cells in S-DMT1 cells after Aβ42 oligomer treatment was significantly reduced.Heochst33258 staining results showed that the rate of nuclear shrinkage in S-DMT1 cells treated with Aβ142 oligomer was significantly higher than that in SGFP group.Moreover,the levels of caspase-3 and Bax proteins in S-DMT1 cells were higher than those in SGFP group,while BcI-2 decreased after Aβ42 oligomers.DMT1 overexpression increases the toxic effects of Aβ42 oligomers by promoting apoptosis.4.Regulation of'P35/P25-CDK5-Tau'signaling pathway in hippocampi and prefrontal cortex of AD rats by electroacupuncture. | Cheng Xiaofeng Li Xinlu Lingeng Tong Liutong Zhengwei | 2021 | 解剖学杂志2021，44，S01： | 0 |
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