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| 1 | Ca^(2+) involvement in activation of extracellular-signal- regulated-kinase 1/2 and m-calpain after axotomy of the sciatic nerve显示文摘Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells(SCs), are poorly understood. Here, we investigated axotomy-induced activation of extracellular-signal-regulated kinase-1/2(ERK1/2; important for proliferation) and m-calpain in vitro, and the relation to Ca2+ deletion and Schwann cell proliferation and death after rat sciatic nerve axotomy. Nerve segments were cultured for up to 72 hours with and without ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid(EGTA). In some experiments, 5-bromo-2′-deoxyuridine(Brd U) was added during the last 24 hours to detect proliferating cells and propidium iodide(PI) was added at the last hour to detect dead and/or dying cells. Immunohistochemistry of sections of the cultured nerve segments was performed to label m-calpain and the phosphorylated and activated form of ERK1/2. The experiments revealed that immunoreactivity for p-ERK1/2 increased with time in organotypically cultured SCs. p-ERK1/2 and m-calpain were also observed in axons. A significant increase in the number of dead or dying SCs was observed in nerve segments cultured for 24 hours. When deprived of Ca2+, activation of axonal m-calpain was reduced, whereas p-ERK1/2 was increased in SCs. Ca2+ deprivation also significantly reduced the number of proliferating SCs, and instead increased the number of dead or dying SCs. Ca2+ seems to play an important role in activation of ERK1/2 in SCs and in SC survival and proliferation. In addition, extracellular Ca2+ levels are also required for m-calpain activation and up-regulation in axons. Thus, regulation of Ca2+ levels is likely to be a useful method to promote SC proliferation. | Lisa B. Martensson Charlotta Lindwall Blom Lars B. Dahlin | 2017 | Neural Regeneration Research2017，12，4： | 4 |
| 2 | 保护性耕作小麦—玉米农田生态系统能流特点的研究显示文摘通过在黑龙港地区主要土壤类型壤质潮土上连续3年的耕作试验,研究在不同耕作条件下农田生态系统的能流特点与能量分配的合理性。结果表明,与传统耕作制度相比,保护性耕作(免耕)能够明显提高小麦—玉米一年两作农田生态系统的能量转化率,能量投产比间的差异显著(P<0.01);不同耕作农田生态系统的熵变和自由能绝对值的差异均无统计学意义,但在一定程度上表明免耕增强了农田生态系统的有序性,从而提高了系统的相对生产力。 | 孙海国 李卫 任图生 Francis J.Larney C.Wayne Lindwall | 1995 | 生态农业研究1995，3，2： | 2 |
| 3 | Circulating CXCR5~ CD4~ helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production显示文摘 | Zhang X Lindwall E Gauthier C | 2015 | Lupus2015，24，9： | 1 |
| 4 | Expression of ezrin radixin moesin proteins in the adult subventrieular zone and the mstral migratory stream 显示文摘 | Persson A Lindwall C Curtis M A el al | 2010 | Neuroscience2010，167，2： | 1 |
| 5 | Phosphorylation affects the ability of tau protein to promote microtubule assembly显示文摘 | Lindwall G Cole R D | 1984 | J Biol Chem1984，259，8： | 1 |
| 6 | The Janus role of c- Jun: cell death versus survival and regeneration of neonatal sympathetic and sensory neurons显示文摘 | Lindwall C Kanje M | 2005 | Exp Neurol2005，196，1： | 1 |
| 7 | Acute barium nitrate intoxication treated by hemodialysis 显示文摘 | Bahlmann H Lindwall R Persson H | 2005 | Acta Anaesthesiol Scand2005，49，1： | 1 |
| 8 | A pilot study of inhaled nitric-oxide in preterm infants treated with nasal continu ous positive airway pressure for respiratory distress syndrome显示文摘 | Lindwall R Blennow M SvenssonM | | 0，，7： | 1 |
| 9 | Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons显示文摘 | Lindwall C Dahlin L Lundborg G Kanje M | 2004 | Mol Cell Neurosci2004，27，3： | 1 |
| 10 | Effect of long-term minimum tillage practices on some physical properties of a Chernozemic clay loam显示文摘 | Chang C Lindwall C W | | 0，，03： | 1 |
| 11 | Phosphorylation affects the ability of tau protein to promote microtubule assembly显示文摘 | COLE R D | 1984 | J Biol Chem1984，259，： | 1 |
| 12 | Acute barium nitrate intoxication treated by hemodialysis 显示文摘 | Bahlmann H Lindwall R Persson H | 2005 | Acta Anaesthesiologica Scandinavica2005，49，1： | 1 |
| 13 | Dimensionality and directionality effects in Newmark sliding block analyses 显示文摘 | Kramer S L Lindwall N W | 2004 | Journal of Geotechnical and Geoenvironmental Engineering2004，130，3： | 1 |
| 14 | The Janus role of c-Jun: cell death versus survival and regeneration of neonatal sympathetic and ensoryneurons显示文摘 | Lindwall C Kanje M | 2005 | Exp Neurol2005，196，1： | 1 |
| 15 | Teaching and learning podcasting through blogging显示文摘 | BERGSTROM P LINDWALL K | 2008 | Journal oF Re- search in Teacher Education2008，，34： | 1 |
| 16 | The effects of a 6-month exercise intervention program on physical self-perceptions and social physique anxiety in non-physiclly active adolescent Swedish girls显示文摘 | Magnus Lindwall Eva-Carin Lindgren | 2005 | Psychology of Sport and Exercise2005，6，： | 1 |
| 17 | Patients and nurses experiences of perioperative dialogues显示文摘 | Lindwall L Bergbom I | | 0，，03： | 1 |
| 18 | The effects of a 6-month exercise inter- vention programme on physical self-perceptions and social phy- sique anxiety in non-physically active adolescent Swedish girls 显示文摘 | Lindwall M Lindgren EC | 2005 | Psychology of Sport and Exercise2005，6，6： | 1 |
| 19 | Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat no- dose ganglia and dorsal root ganglia sensory neurons 显示文摘 | Lindwall C Dahlin L Lundborg G | 2004 | Molecular and Cellular Neuroscience2004，27，3： | 1 |
| 20 | NasalCPAP and surfactant for treatment of respiratory distress syndromeand prevention of bronchopulmonary dysplasia显示文摘 | Verder H Bohlin K Kamper J Lindwall R Jonsson B | 2009 | Acta Paediatr2009，98，9： | 1 |
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