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| 1 | Analysis and external validation of a nomogram to predict peritoneal dissemination in gastric cancer显示文摘Objective:Peritoneal dissemination is difficult to diagnose by conventional imaging technologies.We aimed to construct a nomogram to predict peritoneal dissemination in gastric cancer(GC)patients.Methods:We retrospectively analyzed 1,112 GC patients in Sun Yat-sen University Cancer Center between2001 and 2010 as the development set and 474 patients from The Sixth Affiliated Hospital,Sun Yat-sen University between 2010 and 2016 as the validation set.The clinicopathological variables associated with gastric cancer with peritoneal dissemination(GCPD)were analyzed.We used logistic regression analysis to identify independent risk factors for peritoneal dissemination.Then,we constructed a nomogram for the prediction of GCPD and defined its predictive value with a receiver operating characteristic(ROC)curve.External validation was performed to validate the applicability of the nomogram.Results:In total,250 patients were histologically identified as having peritoneal dissemination.Logistic regression analysis demonstrated that age,sex,tumor location,tumor size,signet-ring cell carcinoma(SRCC),T stage,N stage and Borrmann classification IV(Borrmann IV)were independent risk factors for peritoneal dissemination.We constructed a nomogram consisting of these eight factors to predict GCPD and found an optimistic predictive capability,with a C-index of 0.791,an area under the curve(AUC)of 0.791,and a 95%confidence interval(95%CI)of 0.762-0.820.The results found in the external validation set were also promising.Conclusions:We constructed a highly sensitive nomogram that can assist clinicians in the early diagnosis of GCPD and serve as a reference for optimizing clinical management strategies. | Xijie Chen Shi Chen Xinyou Wang Runcong Nie Dongwen Chen Jun Xiang Yijia Lin Yingbo Chen Junsheng Peng | 2020 | Chinese Journal of Cancer Research2020，32，2： | 6 |
| 2 | Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701显示文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans. | Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 3 |
| 3 | Impact of EV load uncertainty on optimal planning for electric vehicle charging station显示文摘With the development of electric vehicles(EV), there is a huge demand for electric vehicle charging stations(EVCS). The utilization of renewable energy sources(RES) in EVCS can not only decrease the energy fluctuation by participating in peakload reduction of the grid, but also reduce the pollution to the environment by cutting down the use of fossil fuels. In this paper,the optimal planning for grid-connected EVCS with RES is studied by considering EV load uncertainty. Nine scenarios are set based on a different characteristic of EV load to reveal the impact of EV load on net present cost(NPC) and to express the relationship between the optimal capacity and energy flow. Moreover, since electricity price also plays an important role in EVCS planning, an economic comparison between different cases with different electricity prices for peak-valley-flat period is carried out. The results reveal the economic benefits of applying RES in EVCS, and demonstrate that EV load with different characteristics would influence the capacity of each device(PV, battery, converter) in the EVCS optimal planning. | LONG YiLin LI Yong WANG YaHui CAO YiJia JIANG Lin ZHOU YiCheng DENG YouYue NAKANISHI Yosuke | 2021 | Science China(Technological Sciences)2021，64，11： | 3 |
| 4 | Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins显示文摘Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.The backbones of piericidins are derived fromβ,δ-diketo carboxylic acids,which are offloaded from a modular polyketide synthase(PKS)and putatively undergo a carbonyl amidation beforeα-pyridone ring formation.The tailoring modifications to theα-pyridone structure mainly include the verified hydroxylation and O-methylation of the C-4′position and an unidentified C-5′O-methylation.Here,we describe a piericidin producer,terrestrial Streptomyces conglobatus,which contains a piericidin biosynthetic gene cluster in two different loci.Deletion of the amidotransferase gene pieD resulted in the accumulation of two fatty acids that should be degraded from the nascent carboxylic acid released by the PKS,supporting the carbonyl amidation function of PieD duringα-pyridone ring formation.Deletion of the O-methyltransferase gene pieB1 led to the production of three piericidin analogues lacking C-5′O-methylation,therefore confirming that PieB1 specifically catalyses the tailoring modification.Moreover,bioactivity analysis of the mutant-derived products provided clues regarding the structure-function relationship for antitumor activity.The work addresses two previously unidentified steps involved in pyridyl pharmacophore formation during piericidin biosynthesis,facilitating the rational bioengineering of the biosynthetic pathway towards valuable antitumor agents. | Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi Hou-Wen Lin Yongjun Zhou | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
| 5 | Natural hedging of life and annuity mortality risks显示文摘 | Cox S H Lin Yijia | 2007 | North American Actuarial Journal2007，11，3： | 1 |
| 6 | Over‐expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH‐3T3 cells显示文摘 | Fuwei Lin Yijia Chen Xiaolong Li Qing Zhao Zhen Tan | 2012 | Cell Biochem Funct2012，，2： | 1 |
| 7 | Mortality port- folio risk management显示文摘 | Cox S H Lin Yijia Tian Ruilin | 2013 | Journal of Risk and Insur- ance2013，80，4： | 1 |
| 8 | A multi-band atomic candle with microwave-dressed Rydberg atoms显示文摘Stabilizing important physical quantities to atom-based standards lies at the heart of modern atomic,molecular and optical physics,and is widely applied to the field of precision metrology.Of particular importance is the atom-based microwave field amplitude stabilizer,the so-called atomic candle.Previous atomic candles are realized with atoms in their ground state,and hence suffer from the lack of frequency band tunability and small stabilization bandwidth,severely limiting their development and potential applications.To tackle these limitations,we employ microwave-dressed Rydberg atoms to realize a novel atomic candle that features multi-band frequency tunability and large stabilization bandwidth.We demonstrate amplitude stabilization of microwave field from C-band to Ka-band,which could be extended to quasi-DC and terahertz fields by exploring abundant Rydberg levels.Our atomic candle achieves stabilization bandwidth of 100 Hz,outperforming previous ones by more than two orders of magnitude.Our simulation indicates the stabilization bandwidth can be further increased up to 100 kHz.Our work paves a route to develop novel electric field control and applications with a noise-resilient,miniaturized,sensitive and broadband atomic candle. | Yafen Cai Shuai Shi Yijia Zhou Jianhao Yu Yali Tian Yitong Li Kuan Zhang Chenhao Du Weibin Li Lin Li | 2023 | Frontiers of physics2023，18，1： | 1 |
| 9 | Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway显示文摘 | Jiaying Wu Zongfu Pan Zhiqiang Wang Wenjie Zhu Yuanyuan Shen Rong Cui Jiazhen Lin Hao Yu Qiongque Wang Jianchang Qian Yongping Yu Danyan Zhu Yijia Lou | 2012 | Neuropharmacology2012，，3： | 1 |
| 10 | Biomolecular Event Trigger Detection Using Neighborhood Hash Features显示文摘 | Zhang Yijia Lin Hongfei Yang Zhihao | | 0，，： | 1 |
| 11 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 12 | A Breeze Blowing from Daming Mountain显示文摘Xu Xiake,a renowned traveler in the Ming Dynasty whose aspiration was to commune with nature during his lifetime,began to travel around every famous mountain and great river in China in his early twenties.When Xu arrived in Shanglin County,Guangxi in 1637,he was already in a doddering old age.In The Travels of Xu Xiake,he wrote,'I was wandering through steep mountains northward and attracted by two lofty mountain peaks when staring into the distance westward.The mountain shrouded by clouds is exactly Daming Mountain.' | Lin Han Chen Yijia(译) | 2023 | 中国-东盟博览2023，，9： | 0 |
| 13 | Application of Brain-Computer-Interface in Awareness Detection Using Machine Learning Methods显示文摘The awareness detection in patients with disorders of consciousness currently relies on behavioral observations and CRS-R tests,however,the misdiagnosis rates have been relatively high.In this study,we applied brain-computer interface(BCI)to awareness detection with a passive auditory stimulation paradigm.12 subjects with normal hearing were invited to collect electroencephalogram(EEG)based on a BCI communication system,in which EEG signals are transmitted wirelessly.After necessary preprocessing,RBF-SVM and EEGNet were used for algorithm realization and analysis.For a single subject,RBF-SVM can distinguish his(her)name stimuli awareness with classification accuracies ranging from 60-95%.EEGNet was used to learn all subjects'data and improved accuracy to 78.04%for characteristics finding and model generalization.Moreover,we completed the supplementary analysis work from the time domain and time-frequency domain.This study applied BCI communication to human awareness detection,proposed a passive auditory paradigm,and proved the effectiveness,which could be an inspiration for brain,mental or physical diseases diagnosis and detection. | Kaiqiang Feng Weilong Lin Feng Wu Chengxin Pang Liang Song Yijia Wu Rong Cao Huiliang Shang Xinhua Zeng | 2022 | China Communications2022，19，6： | 0 |
| 14 | Entrainment of Astrocytic and Neuronal Ca^(2+) Population Dynamics During Information Processing of Working Memory in Mice显示文摘Astrocytes are increasingly recognized to play an active role in learning and memory,but whether neural inputs can trigger event-specific astrocytic Ca^(2+)dynamics in real time to participate in working memory remains unclear due to the difficulties in directly monitoring astrocytic Ca^(2+)dynamics in animals performing tasks.Here,using fiber photometry,we showed that population astrocytic Ca^(2+)dynamics in the hippocampus were gated by sensory inputs(centered at the turning point of the T-maze)and modified by the reward delivery during the encoding and retrieval phases.Notably,there was a strong inter-locked and antagonistic relationship between the astrocytic and neuronal Ca^(2+)dynamics with a 3-s phase difference.Furthermore,there was a robust synchronization of astrocytic Ca^(2+)at the population level among the hippocampus,medial prefrontal cortex,and striatum.The inter-locked,bidirectional communication between astrocytes and neurons at the population level may contribute to the modulation of information processing in working memory. | Zhu Lin Feng You Ting Li Yijia Feng Xinyue Zhao Jingjing Yang Zhimo Yao Ying Gao Jiang-Fan Chen | 2022 | Neuroscience Bulletin2022，38，5： | 0 |
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