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| 1 | Characterization of red mud derived from a combined Bayer Process and Calcining method for alumina refining显示文摘 | Chuxia LIN Yonggui LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 5 |
| 2 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 3 | Characterization of red mud derived from a combined Bayer process and bauxite calcinations method显示文摘 | LIU Yong LIN Chuxia WU Yonggui | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 4 | Characterization of red mud derived from a combined bayer process and bauxite cal- cinations method显示文摘 | Liu Yong Lin Chuxia Wu Yong | 2007 | J Hazard Mater2007，146，12： | 1 |
| 5 | Physiological, biochemical and growth responses of Italian ryegrass to butachlor exposure显示文摘 | Shaorui Wang Huashou Li Chuxia Lin | 2013 | 2013 (1-2)2013，，1： | 1 |
| 6 | Plant uptake and in-soil degradation of PCB-5 under varying cropping conditions显示文摘 | Li Huashou Liu Longyuan Lin Chuxia | | 0，，84： | 1 |
| 7 | Characterization of red mud derived from a combined bayer process and bauxite calcination method显示文摘 | Liu Yong Lin Chuxia Wu Yonggui | 2007 | J Hazard Mater2007，146，12： | 1 |
| 8 | Competitive removal of water-borne copper, zinc and cadmium by a CaCO 3 -dominated red mud显示文摘 | Yingqun Ma Chuxia Lin Yuehua Jiang Wenzhou Lu Chunhua Si Yong Liu | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 9 | Characterization of red mud derived from a combined Bayer process and bauxite calcinations method显示文摘 | LIU YONG LIN CHUXia WU YONG | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 10 | Can rainwater induce Fenton-driven degradation of herbicides in natural waters?显示文摘 | Junhao Qin Huashou Li Chuxia Lin Gu Chen | 2013 | Chemosphere2013，，8： | 1 |
| 11 | Characterization of red mud derived rom a combined Bayer Process and bauxite calcination method 显示文摘 | Liu Yong Lin Chuxia Wu Yonggui | 2007 | J Hazard Mater2007，146，12： | 1 |
| 12 | Human Influences on the Development of Acid Sulphate Soils in the Pearl River (the Zhujiang) Delta显示文摘HumanInfluencesontheDevelopmentofAcidSulphateSoilsinthePearlRiver(theZhujiang)Delta￥LINCHUXIA(choolOfGeography,TheUniversityo... | LIN CHUXIA(chool Of Geography, The University of New South Wales, Sydney, N. S. W. 2052 (Australia)) | 1996 | Pedosphere1996，6，1： | 0 |
| 13 | Impacts of acid mine drainage on a stream in subtropical China during a major flood event显示文摘 | Chuxia LIN Yonggui WU Wenzhou LU Aisheng CHEN Yong LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 14 | Transformation and immobilization of hexavalent chromium in the co-presence of biochar and organic acids:effects of biochar dose and reaction time显示文摘A batch experiment was conducted to examine the effects of biochar dose and reaction duration on the transformation and immobilization of Cr(VI)in the combined biochar and low-molecular-weight organic acid systems.The results showed that increase in the dosage level of biochar caused increase in the solution pH,particularly for the Biochar300 treatments but did not enhance the reduction of Cr(VI)after 1-day reaction.Over 35%of the converted Cr(III)was immobilized by sorption to the biochar due to increased negatively charged sites on the biochar surfaces driven by pH rise.The elevated pH due to biochar dose increase tended to slow down the reduction of Cr(VI)to Cr(III),resulting in more Cr(VI)being adsorbed at a higher biochar dose.For the higher-temperature biochars,the increase in biochar dose did not markedly change the transformation and immobilization of the added Cr.Increase in the reaction duration markedly increased the pH for Biochar300.This resulted in the disappearance of all Cr(VI)in the solution after the 7-day reaction,possibly through sorption of cationic Cr(III)to the biochar surfaces.Increase in reaction time for the higher-temperature biochars resulted in re-oxidation of Cr(III)to Cr(VI)due to the increased exposure of solution Cr(III)to atmospheric oxygen.The research findings obtained from this study have implications for optimizing treatment procedure for wastewater that contains elevated level of toxic Cr(VI).Simulation experiments are required to determine appropriate biochar dose and reaction time to achieve cost-effective treatment goals. | Yongjun Li Wenming Xiong Xin Wei Junhao Qin Chuxia Lin | 2021 | Biochar2021，3，4： | 0 |
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