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| 1 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 2 | Analysis of inflammatory infiltrate,perineural invasion,and risk score can indicate concurrent metastasis in squamous cell carcinoma of the tongue 显示文摘 | de Matos FR Lima Ed Queiroz LM | 2012 | J Oral Maxillofac Surg2012，70，7： | 1 |
| 3 | Leiomyomas of the kidney: emphasis on conservative diagnosis and treatment显示文摘 | ROMERO FR KOHANIM S LIMA G | 2005 | Urology2005，66，6： | 1 |
| 4 | Glioblastoma cells: a heteroge-neous and fatal tumor interacting with the parenchyma显示文摘 | Alves TR Lima FR Kahn SA | 2011 | Life Sci2011，89，15： | 1 |
| 5 | STIM1/Orail contrib- utes to sex differences in vascular responses to Calcium in spontane- ously hypertensive rats显示文摘 | Giaehini FR Lima VV Filgueira FP | 2012 | Clin Sci2012，122，5： | 1 |
| 6 | Glioblastoma: ther- apeutic challenges, what lies ahead 显示文摘 | Lima FR Kahn SA Soletti RC et ol | 2012 | Biochim Biophys Acta2012，1826，2： | 1 |
| 7 | Leiomyomas of the kidney:emphasis on conservative diagnosis and treatment显示文摘 | Romero FR Kohanim S Lima G | 2005 | Urology2005，66，： | 1 |
| 8 | Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parcnchy- ma显示文摘 | ALVES TR LIMA FR KAHN SA | 2011 | Life Sci2011，89，1516： | 1 |
| 9 | Glioblastoma: thera- peutic challenges, what lies ahead显示文摘 | Lima FR Kahn SA Soletti RC | 2012 | Bioehim Biophys Acta2012，1826，2： | 1 |
| 10 | Glioblastoma: therapeutic challenges,what lies ahead显示文摘 | Lima FR Kahn SA Soletti RC | 2012 | Biochim Biophys Acta2012，1826，2： | 1 |
| 11 | Compliance with support-ive periodontal therapy and its relation to the bleeding index 显示文摘 | Novaes AB Jr De Lima FR Novaes AB | 1996 | JPeriodontol1996，67，10： | 1 |
| 12 | Regulation of microglial development a novel role for thyroid hormone显示文摘 | Lima FR Gervais A Colin C | 2000 | J Neurosci2000，21，6： | 1 |
| 13 | Compliance with supportive periodontal therapy and its relation to the bleeding index显示文摘 | Novaes AB Jr De Lima FR Novaes AB | 1996 | J Periodontol1996，67，10： | 1 |
| 14 | Leiomyomas of the kidney:emphasis on conservative diagnosis and treatment显示文摘 | Romero FR Kohanim S Lima G | | 0，，10： | 1 |
| 15 | Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchy- ma显示文摘 | ALVES TR LIMA FR KAHN SA | 2011 | Life Sci2011，89，1516： | 1 |
| 16 | BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists 显示文摘 | dos Santos Silva CM Barbosa FR Lima GA | 2011 | Obesity2011，19，4： | 1 |
| 17 | Membrane elastic properties and cell function显示文摘 | Pontes B Ayala Y Fonseca ACC Rom?o LF Amaral RF Salgado LT Lima FR Farina M Viana NB Moura-Neto V Nussenzveig HM | | 0，，： | 1 |
| 18 | Compliance with supportive periodontal therapy and its relation to the bleeding index 显示文摘 | Novaes AB Jr de Lima FR Novaes AB | 1996 | J Periodontol1996，67，10： | 1 |
| 19 | Congenital intrahepatic arterioportal fistula presenting as severe undernutrition and chronic watery diarrhea in a 2-year-old girl 显示文摘 | Tannuri AC Tannuri U Lima FR | 2009 | J Pediatr Surg2009，44，10： | 1 |
| 20 | Melatonin administration after pilo- carpine-induced status epilepticus-A new way to prevent or attenuate- postlesion 显示文摘 | Lima E Cabrel FR Cavalheim EA | 2011 | Epilepsy2011，20，4： | 1 |
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