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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Current status of radiofrequency ablation of hepatocellular carcinoma显示文摘Loco-regional treatments for hepatocellular carcinoma(HCC) are important alternatives to curative transplantation or resection.Among them,radiofrequency ablation(RFA) is accepted as the most popular technique showing excellent local tumor control and acceptable morbidity.The current role of RFA is well documented in the evidence-based practice guidelines of European Association of Study of Liver,American Association of Study of the Liver Disease and Japanese academic societies.Several randomized controlled trials have confirmed that RFA is superior to percutaneous ethanol injections in terms of local tumor control and survival.The overall survival after RFA is comparable to after surgical resection in a selected group of patients with smaller(< 3 cm) tumors.Currently,the clinical benefits of combined RFA with transarterial chemoembolization for intermediate stage HCC are increasingly being explored.Here we review the ongoing technical advancements of RFA and future potential. | Hyunchul Rhim Hyo K Lim Dongil Choi | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 7 |
| 3 | Concurrent and subsequent radiofrequency ablation combined with hepatectomy for hepatocellular carcinomas显示文摘Partial hepatectomy has long been the standard treatment modality for patients with hepatocellular carcinoma(HCC),although the majority of patients with HCCs are not candidates for curative resection.Radiofrequency ablation(RFA) has been widely used as the preferred locoregional therapy.RFA and hepatectomy can be complementary to each other for the treatment of multifocal HCCs.Combining hepatectomy with RFA permits the removal of larger tumors while simultaneously ablating any smaller residual tumors.By using this combination treatment,more patients might become candidates for curative resection.For treating recurrent tumors involving the liver after hepatectomy,RFA has been performed recently instead of transcatheter arterial chemoembolization or ethanol ablation.Many retrospective studies on the combination of RFA and hepatectomy demonstrate favorable results of effectiveness and safety.However,further investigation of prospective design will be needed to confirm these encouraging results. | Dongil Choi Hyo K Lim Hyunchul Rhim | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 6 |
| 4 | Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(HCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to HCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-HCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-HCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-HCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. However, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-HCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated HCC. | Carrie R Wong Mindie H Nguyen Joseph K Lim | 2016 | World Journal of Gastroenterology2016，22，37： | 5 |
| 5 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 6 | Operating characteristics of aerated submerged biofilm reactors for drinking water treatment 显示文摘 | Lim K H Shin H S | 1997 | Wat Sci Tech1997，36，12： | 2 |
| 7 | The effect of liquid channeling on distillation plate efficiency显示文摘 | Porter K E Lockett M J Lim C T | 1972 | Trans IchemE1972，50，： | 2 |
| 8 | Advances in white matter imaging: a review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging 显示文摘 | Womiak J R and K 0 Lim | 2006 | Neumsci Biobehav Rev2006，30，6： | 1 |
| 9 | Homoeologous recombination in 2n-ganetes producing interspecific hybrids of Lilium(Liliaceae)studied by genomic in stiu hybridization (GISH)显示文摘 | KARLOV G KHRUSTALEVA L L LIM K B | 1999 | Genome1999，42，： | 1 |
| 10 | Cosmic rays: are air crew at risk?显示文摘 | LIM M K | 2002 | Occup Environ Med2002，59，7： | 1 |
| 11 | Electrical,optical and structural characteristics of indium-tin-oxide thin films deposited on glass and polymer substrates 显示文摘 | Schulz K H Lim T S | 1997 | Thin Solid Films1997，3083，： | 1 |
| 12 | Synthesis and properties of semifluorinated block copolymers containing poly(ethylene oxide) and poly(fluorooctyl methacrylates) via atom transfer radical polymerization显示文摘 | Lee M Y Moon M J | 2002 | Polymer2002，43，： | 1 |
| 13 | Flowdfield around ogive/elliptic-tip cylinder at high angle of attack显示文摘 | LIM T T LUA K B | 1998 | AIAA Journal1998，36，10： | 1 |
| 14 | A molecular mechanism of action of theophyline : induction of histone deacetylase activity to decrease inflammatory gene expression 显示文摘 | ITO K LIM S CARAMORI G | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 15 | Ions released from dental amalgams in contact with titanium显示文摘 | Lim S Takada Y Kiln K | 2003 | Dent Mater J2003，22，1： | 1 |
| 16 | An experimental stuay on the thermal performance of ground heat exchangers显示文摘 | Lim K Lee S Lee C | 2007 | Experimental Thermal and FIuid Science2007，31，8： | 1 |
| 17 | 显示文摘 | Lam S W Chiang K Lim T M | 2005 | Appl Catal B2005，55，2： | 1 |
| 18 | gestational diatebes melli- tus: a call for systestematic tracing 显示文摘 | TAN H H TAN H K LIM H S | 2002 | Ann Acad Med Singa- pore2002，31，3： | 1 |
| 19 | Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma显示文摘 | Lim S Tomita K Carramori G | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 20 | Effect of Mg17Al12 precipitate on Corrosion behavior of AZ91D magnesium alloy 显示文摘 | KO Y J YIM C D LIM J D SHIN K S | 2003 | Mater Science Forum2003，，： | 1 |
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