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| 1 | Percutaneous ablation for perivascular hepatocellular carcinoma: Refining the current status based on emerging evidence and future perspectives显示文摘Various therapeutic modalities including radiofrequency ablation, cryoablation, microwave ablation, and irreversible electroporation have attracted attention as energy sources for effective locoregional treatment of hepatocellular carcinoma(HCC); these are accepted non-surgical treatments that provide excellent local tumor control and favorable survival. However, in contrast to surgery, tumor location is a crucial factor in the outcomes of locoregional treatment because such treatment is mainly performed using a percutaneous approach for minimal invasiveness; accordingly, it has a limited range of ablation volume. When the index tumor is near large blood vessels, the blood flow drags thermal energy away from the targeted tissue, resulting in reduced ablation volume through a socalled 'heat-sink effect'. This modifies the size and shape of the ablation zone considerably. In addition, serious complications including infarction or aggressive tumor recurrence can be observed during follow-up after ablation for perivascular tumors by mechanical or thermal damage. Therefore, perivascular locations of HCC adjacent to large intrahepatic vessels can affect post-treatment outcomes. In this review, we primarily focus on physical properties of perivascular tumor location, characteristics of perivascular HCC,potential complications, and clinical outcomes after various locoregional treatments; moreover, we discuss the current status and future perspectives regarding percutaneous ablation for perivascular HCC. | Tae Wook Kang Hyo Keun Lim Dong Ik Cha | 2018 | World Journal of Gastroenterology2018，24，47： | 10 |
| 2 | Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections显示文摘Background:The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of septicemia.We aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative organisms.Methods:We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December 2015.All patients showed clinical evidence of biliary tract infection and had blood isolates that demonstrated septicemia.Results:Gram-negative,gram-positive,and both types of bacteria caused 84.1%(127/151),13.2%(20/151),and 2.6%(4/151)episodes of septicemia,respectively.The most common infecting organisms were Escherichia coli among gram-negative bacteria and Enterococcus species(Enterococcus casseliflavus and Enterococcus faecalis)among gram-positive bacteria.There were no differences in mortality,re-admission rate,and need for emergency decompression procedures between the gram-positive and gram-negative septicemia groups.In univariate analysis,previous gastrectomy history was associated with gram-positive bacteremia.Multivariate analysis also showed that previous gastrectomy history was strongly associated with gram-positive septicemia(Odds ratio=5.47,95%CI:1.19–25.23;P=0.029).Conclusions:Previous gastrectomy history was related to biliary septicemia induced by gram-positive organisms.This information would aid the choice of empirical antibiotics. | Ik Hyun Jo Yeon-Ji Kim Woo Chul Chung Jaeyoung Kim Seonhoo Kim Eun Sun Lim Honggeun Ahn Seong Yul Ryu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 4 |
| 3 | A Phytochemically character- ized extract of Cordyeeps militaris and cordycepin protect hipp- ocampal neurons from ischemic injury in gerbils显示文摘 | HANG IK LIM SS YOO KY | 2008 | Planta Med2008，74，2： | 1 |
| 4 | Synthesis and luminescent properties of a novel Eu-containing nanoparticle 显示文摘 | Chang Ik Lee Jin Soo Lim Song Ho Kim Dong Hack Suh | 2006 | Polymer2006，47，： | 1 |
| 5 | Spectrum of molecular changes during hepato- carcino genesis induced by DEN and other chemicals in Fischer 344 malerats 显示文摘 | Lim IK | 2003 | Mech Aging Dev2003，124，5： | 1 |
| 6 | Formation of elongated giant mitochondria in DFO-induced cellular senescence:involvement of enhanced fusion process through modulation of Fis1显示文摘 | Yoon YS Yoon DS Lim IK | | 0，，： | 1 |
| 7 | Formation of elongated giant mitochondria in DFO-induced cellular senescence:involvement of enhanced fusion process through modulation of Fis1显示文摘 | Yoon YS Yoon DS Lim IK | 2006 | J Cell Physiol2006，209，2： | 1 |
| 8 | TIS21(/BTG2/PC3) as a link between ageing and cancer,cell cycle regulator and endogenous cell death molecule显示文摘 | Lim IK | 2006 | J Cancer Res Clin Oncol2006，110，： | 1 |
| 9 | Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-de- pendent apoptosis via the generation of reactive oxygen species in human colon cancer cells 显示文摘 | Lee IK Kang KA Lim CM | 2010 | Int J Mol Sci2010，11，12： | 1 |
| 10 | BTG2 suppresses cancer cell mi- gration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria显示文摘 | Lim SK Choi YW Lim IK | 2012 | Clin Exp Metastasis2012，29，8： | 1 |
| 11 | Small-diameter blood vessels engineered with bone marrow-derived cells 显示文摘 | Cho SW Lim SH Kim IK | 2005 | Ann Surg2005，241，3： | 1 |
| 12 | Synaptotagmin 1V is an immediate early gene induced by depolarization in PC12 cells and in brain 显示文摘 | Vician L Lim IK Ferguson G | 1995 | Proc Natl Acad Sci USA1995，92，6： | 1 |
| 13 | Insulin - sensitizing effects of exercise on adiponectin and retinol -binding protein -4 concentra- tions in young and middle - aged women 显示文摘 | Lim S Choi SH Jeong IK | 2008 | Clin Endocrinol Metab2008，93，6： | 1 |
| 14 | Benefit of Negative Pressure Drain Within Surgical Wound After Cytoreductive Surgery for Ovarian Cancer显示文摘 | Se Ik Kim Myong Cheol Lim Hyo Sook Bae Se Ra Shin Sang-Soo Seo Sokbom Kang Sang-Yoon Park | 2015 | International Journal of Gynecological Cancer2015，，1： | 1 |
| 15 | The Dark Side of Information and Market Efficiency in E - Markets*显示文摘 | Grover V Lim J Ayyagari IK | 2006 | Decision Sciences2006，37，3： | 1 |
| 16 | Herogeneous liquid-phase lactonization of 1,4-butadiol using H3+xPMo12-xVxO40 (x = 0 - 3) catalyst immobilized on polyaniline显示文摘 | Seong Soo Lim Gyo Ik Park Jun Seon Choi | 2002 | Catalysis Today2002，74，： | 1 |
| 17 | Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion显示文摘 | Park TJ Paik WK | 2000 | Biochem J2000，3523，： | 1 |
| 18 | TIS21 (/BTG2/PC3) as a link between ageing and cancer,cell cycle regulator and endogenous cell death molecule显示文摘 | Lim IK | 2006 | J Cancer Res Clin Oncol2006，132，7： | 1 |
| 19 | Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia显示文摘 | Yoo KY Hwang IK Lim BO | 2006 | Biol Pharm Bu112006，29，： | 1 |
| 20 | Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women显示文摘 | Lim S Choi SH Jeong IK | 2008 | J Clin Endocrinol Metab2008，93，6： | 1 |
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