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| 1 | Fuzzy adaptive robust control for space robot considering the effect of the gravity显示文摘Space robot is assembled and tested in gravity environment, and completes on-orbit service(OOS) in microgravity environment. The kinematic and dynamic characteristic of the robot will change with the variations of gravity in different working condition. Fully considering the change of kinematic and dynamic models caused by the change of gravity environment, a fuzzy adaptive robust control(FARC) strategy which is adaptive to these model variations is put forward for trajectory tracking control of space robot. A fuzzy algorithm is employed to approximate the nonlinear uncertainties in the model, adaptive laws of the parameters are constructed, and the approximation error is compensated by using a robust control algorithm. The stability of the control system is guaranteed based on the Lyapunov theory and the trajectory tracking control simulation is performed. The simulation results are compared with the proportional plus derivative(PD) controller, and the effectiveness to achieve better trajectory tracking performance under different gravity environment without changing the control parameters and the advantage of the proposed controller are verified. | Qin Li Liu Fucai Liang Lihuan Gao Jingfang | 2014 | Chinese Journal of Aeronautics2014，27，6： | 14 |
| 2 | GENETIC DIVERSITY AND GEOGRAPHIC PATTERN OF WILD LOTUS (NELUMBO NUCIFERA) IN HEILONGJIANG PROVINCE显示文摘Based on 47 accessions from Ussuri River Valley, Songhua River Valley and Heilong River Valley together with 2 accessions from Russia and 27 accessions of cultivated lotus from other provinces in China, genetic diversity of wild lotus (Nelumbo nucifera) were revealed using RAPD and ISSR markers. Twenty RAPD primers generated 113 loci, of which 71.68% were polymorphic across all sam-ples. The expected heterozygosity was 0.1583. The percentage of polymorphic loci and expected het-erozygosity in the wild lotus were 50.44% and 0.1241, respectively. The parameters of the cultivated lotus were slightly higher, 53.98% and 0.1651 corre-spondingly. Sixteen ISSR primers produced 90 loci. The percentages of polymorphic loci and expected heterozygosity were 41.11% and 0.0851 at species level, 28.89% and 0.0661 for the wild lotus, and 32.22% and 0.0963 for the cultivated lotus. AMOVA analysis of the wild lotus showed that a small number of variances exist among the 3 river valleys (21.68% for RAPD with Gst=0.1312 and 15.11% for ISSR with Gst=0.1352). The molecular variances of both the wild and the cultivated lotuses came predominantly from within the 3 river valleys and the cultivated samples (73.25% for RAPD and 81.11% for ISSR). Variance components from the wild and the cultivated lotus accounted for 19.17% for RAPD and 13.17% for ISSR, and variations among the valleys and the culta seemed the least important (7.585 for RAPD and 5.725 for ISSR). Neighbor-joining analysis demon-strated that considerable differentiation happened between the wild and the cultivated lotus. The wildlotus at middle reaches of the Songhua River Valley seemed to be the centre of remnants, from which it spread to the Ussuri River Valley and the Heilong River Valley. The very limited genetic diversity sug- gests that the wild lotus has experienced severe bot- tleneck effect, founder effect and rebirth effect. Con- sidering its long evolutionary history, scarcity of ge- netic variations and importance in wetland ecosys- tems, we appeal to take lawful measures to protect the wild lotus. For conservation purpose, special at- tention should be paid to the lotus at the middle reaches of the Songhua River Valley. | XUE Jianhua ZHUO Lihuan ZHOU Shiliang | 2006 | Chinese Science Bulletin2006，51，4： | 10 |
| 3 | Electrospun Nanofibrous Materials for Wound Healing显示文摘Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired.Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area,better mimicry of native extracellular matrix,adjustable waterproofness and breathability,and programmable drug delivery process.In this review article,we begin with a discussion of wound healing process and current commercial wound dressing materials.Then,we emphasize on electrospun nanofibrous materials for wound dressing,covering the efforts for controlling fiber alignment and morphology,constructing 3D scaffolds,developing waterproof-breathable membrane,governing drug delivery performance,and regulating stem cell behavior.Finally,we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings. | Yuping Dong Yuqi Zheng Keyan Zhang Yueming Yao Lihuan Wang Xiaoran Li Jianyong Yu Bin Ding | 2020 | Advanced Fiber Materials2020，2，4： | 10 |
| 4 | Kiwifruit Genome Database(KGD):a comprehensive resource for kiwifruit genomics显示文摘Kiwifruit(Actinidia spp.)plants produce economically important fruits containing abundant,balanced phytonutrients with extraordinarily high vitamin C contents.Since the release of the first kiwifruit reference genome sequence in 2013,large volumes of genome and transcriptome data have been rapidly accumulated for a handful of kiwifruit species.To efficiently store,analyze,integrate,and disseminate these large-scale datasets to the research community,we constructed the Kiwifruit Genome Database(KGD;http://gffzz6fc08c45f9754a68hfcwfu9qcffpo60wb.ffgz.tsg.suse.edu.cn/).The database currently contains all publicly available genome and gene sequences,gene annotations,biochemical pathways,transcriptome profiles derived from public RNA-Seq datasets,and comparative genomic analysis results such as syntenic blocks and homologous gene pairs between different kiwifruit genome assemblies.A set of user-friendly query interfaces,analysis tools and visualization modules have been implemented in KGD to facilitate translational and applied research in kiwifruit,which include JBrowse,a popular genome browser,and the NCBI BLAST sequence search tool.Other notable tools developed within KGD include a genome synteny viewer and tools for differential gene expression analysis as well as gene ontology(GO)term and pathway enrichment analysis. | Junyang Yue Jiacheng Liu Wei Tang Ya Qing Wu Xiaofeng Tang Wei Li Ying Yang Lihuan Wang Shengxiong Huang Congbing Fang Kun Zhao Zhangjun Fei Yongsheng Liu Yi Zheng | 2020 | Horticulture Research2020，7，1： | 6 |
| 5 | Exploitation of Wild Flowers and the Sustainable Development of Flowers Industry in China显示文摘This article introduced the new methods on the research of the wild flowers and plants idioplasmic resources,elaborated the introduction and domestication and exploitation of wild flowers and plants idioplasmatic resources and the sustainable development of flowers and plants industry in China,and put forward some proposals on the existing question and the prospects for the development. | HONG Li PANG Songling ZHUO Lihuan | 2008 | Journal of Northeast Agricultural University(English Edition)2008，15，2： | 4 |
| 6 | The Classification of Colorful-leaf Tree Species and the Application in Landscape Architecture显示文摘This paper summarized the classification of colorful tree species and the application principles on landscape architecture and briefly introduced the present application situation of colorful tree species in China.It also raised suggestions related to the introduction and application of the colorful tree species. | HONG Li ZHUO Lihuan | 2008 | Journal of Northeast Agricultural University(English Edition)2008，15，1： | 3 |
| 7 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
| 8 | Cellulose Nanofibrous Membranes Modified with Phenyl Glycidyl Ether for Efficient Adsorption of Bovine Serum Albumin显示文摘Hydrophobic interaction chromatography(HIC)as an indispensable method for protein purification has attracted considerable attentions of researchers as well as biopharmaceutical industries.However,the low binding capacity and slow adsorption rate of the currently available HIC media lead to a little supply and high price of the highly purified proteins.Herein,nanofibrous membranes with hydrophobic binding sites were developed for HIC by directly coupling phenyl glycidyl ether on the hydrolyzed cellulose acetate nanofiber membrane(cellulose-phenyl NFM).Scanning electron microscope(SEM),water contact angle(WCA),Fourier transform infrared(FTIR),thermogravimetric analysis(TGA),Brunauer-Emmett-Teller(BET)surface area analysis and capillary flow porometer(CFP)were applied to evaluate the physically and chemically structural transformation.The obtained cellulose-phenyl NFMs showed a proper hydrophilcity(WCA=37°),a relatively high BET surface area(3.6 times the surface area of commercial fibrous membranes),and tortuous-channel structure with through-hole size in the range of 0.25-1.2μm,which led to a little non-specificity adsorption,high bovine serum albumin adsorption capacity of 118 mg g^(−1),fast adsorption process within 12 h,good long-term stability and reusability.Moreover,compared with traditional modification methods which always include activation and graft two steps,direct coupling method is more efficient for HIC media fabrication.Therefore,cellulose-phenyl NFMs with outstanding protein adsorption performance could be a kind of promising candidate for HIC. | Lihuan Wang Qiuxia Fu Jianyong Yu Lifang Liu Bin Ding | 2019 | Advanced Fiber Materials2019，1，3： | 3 |
| 9 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 10 | 显示文摘 | ZHAOJia ZHOUFeng LIHuan etal(赵佳 周峰 李欢 等) | 2014 | 航天返回与遥感2014，35，2： | 2 |
| 11 | Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis显示文摘 | Suhui Wu Haixia Shang Lihuan Cui Zheng Zhang Yanli Zhang Ying Li Jun Wu Ren-Ke Li Jun Xie | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 12 | Estrogen receptor beta modulatessynthesis of bone matrix proteins in human osteoblast-like MG63 cells 显示文摘 | LIHUAN C RONGFA B JENNIFER I | 2003 | J Cell Biochem2003，89，1： | 1 |
| 13 | Peripheral CD24hi CD27 + CD19 + B cells subset as a potential biomarker in naYve systemic lupus erythcmatosus显示文摘 | Jin L Weiqian C Lihuan Y | 2013 | Int J Rheum Dis2013，16，6： | 1 |
| 14 | Epidemiology and etiological characteristics of hand,foot,and mouth disease in Huizhou City between 2008 and 2011显示文摘 | Qiaoyun F Xiongfei J Lihuan L | | 0，，04： | 1 |
| 15 | GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin显示文摘 | Feng Wang Zhiwen Xu Lihuan Ren | 2008 | Neuropharmacology2008，55，： | 1 |
| 16 | Hierarchical Porous Patterns of n-type 6H-SiC Crystals via Photoelectrochemical Etching显示文摘Hierarchical porous patterns have been fabricated on the C face,Si face,and cross section of n-type 6H—SiC crystal via photo-electrochemical etching using HF/C_2H_5OH and HF/H_2O_2 as electrolytes.The porous layer displayed multiple and multiscale microstructures on different faces,including stalactite-like,sponge-like and dendritic porous structures on C face,echinoid micro-patterns on Si face,and columnar and keel-shaped micro-patterns on the cross section.The formation of hierarchical porous pattern is ascribed to the dynamic competition balance between the electrochemical oxidation rate and the oxide removal rate.It was found that increasing the ionic strength of the electrolyte can obviously disturb the surface morphology of the porous SiC during the photo-electrochemical etching.Possible mechanisms for selective etching were further discussed. | Lihuan Wang Huihui Shao Xiaobo Hu Xiangang Xu | 2013 | Journal of Materials Science & Technology2013，29，7： | 1 |
| 17 | Biosensor based on self-assembling glucose oxidase and dendrimer-encapsulated Pt nanopartieles on earbon nanotubes for glucose detection 显示文摘 | Xu Lihuan Zhu Yihua Tang Longhua | 2007 | Electroanalysis2007，19，： | 1 |
| 18 | Al^(3+)-induced vesicle formation显示文摘Aluminium laurate [Al(OOCC11H23)3] was synthesized as a surfactant, which can dissolve in micellar solution of a zwitterionic surfactant, tetradecycldimethylamine oxide (C14DMAO). The phase behavior of the mixtures of Al(OOCC11H23)3 and C14DMAO in water was studied and birefringent Lα-phase was observed. The birefringent Lα-phase consists of vesicles that were demonstrated by Polarizer and Transmission Electron Microscope (TEM) micrographs. Al3+-coordinated vesicles could be used as templating-precursor, providing a vesicle-route for preparation of inorganic nanoscale particles. | DONG RenHao WANG LiHuan YUAN ZaiWu SONG AiXin HAO JingCheng | 2007 | Chinese Science Bulletin2007，52，19： | 1 |
| 19 | Ulinastatin as a neuroprotective and anti‐inflammatory agent in infant piglets model undergoing surgery on hypothermic low‐flow cardiopulmonary bypass显示文摘 | Xiaocou Wang Qinghua Xue Fuxia Yan Lihuan Li Jinping Liu Shoujun Li Shengshou Hu | 2013 | Paediatr Anaesth2013，，3： | 1 |
| 20 | Epidemiology and etiological characteristics of hand,foot and mouth disease in Huizhou City between 2008 and 2011显示文摘 | Qiaoyun F Xiongfei J Lihuan L | 2013 | Arch Virol2013，158，4： | 1 |
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