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| 1 | A new method of block shape classification显示文摘The shapes of block within the rock mass have an important effect on the rock properties,so it’s very important to evaluate the shapes of rock fragmentation and to determine the geometric characteristics distribution of the block. The previous methods to classify rock block shape are based on the assumption that a block shape is approximately orthogonal,which is acceptable in only a few rock masses. This paper proposes a new method for block shape classification using triangular diagram together with parameters of co-linearity ε and volume coefficient κ,which combines the shape categorization with block volume for statistical analysis. Rock block equivalent size calculation methods based on block shape is proposed and the block cumulative percentage of total volume statistical analysis is given. In order to verify this block shape classification method,three ideal rock masses with approximately orthogonal joint sets have been generated and simulated. | FENG XingLong LI De WANG LiGuan JING YongBin XUN XueMei ZENG QingTian | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 2 | ARGs-OAP v3.0:Antibiotic-Resistance Gene Database Curation and Analysis Pipeline Optimization显示文摘Antibiotic resistance,which is encoded by antibiotic-resistance genes(ARGs),has proliferated to become a growing threat to public health around the world.With technical advances,especially in the popularization of metagenomic sequencing,scientists have gained the ability to decipher the profiles of ARGs in diverse samples with high accuracy at an accelerated speed.To analyze thousands of ARGs in a highthroughput way,standardized and integrated pipelines are needed.The new version(v3.0)of the widely used ARGs online analysis pipeline(ARGs-OAP)has made significant improvements to both the reference database-the structured ARG(SARG)database-and the integrated analysis pipeline.SARG has been enhanced with sequence curation to improve annotation reliability,incorporate emerging resistance genotypes,and determine rigorous mechanism classification.The database has been further organized and visualized online in the format of a tree-like structure with a dictionary.It has also been divided into sub-databases for different application scenarios.In addition,the ARGs-OAP has been improved with adjusted quantification methods,simplified tool implementation,and multiple functions with userdefined reference databases.Moreover,the online platform now provides a diverse biostatistical analysis workflow with visualization packages for the efficient interpretation of ARG profiles.The ARGs-OAP v3.0 with an improved database and analysis pipeline will benefit academia,governmental management,and consultation regarding risk assessment of the environmental prevalence of ARGs. | Xiaole Yin Xiawan Zheng Liguan Li An-Ni Zhang Xiao-Tao Jiang Tong Zhang | 2023 | Engineering2023，，8： | 0 |
| 3 | Roadmap to tackle antibiotic resistance in the environment under the One Health framework显示文摘Antibiotic resistance has been recognized as a major challenge worldwide for humans.“One Health”has been recognized as a key concept for containment of antibiotic resistance.Under the framework,the role of the environment in the development of antibiotic resistance genes(ARGs)has become increasingly obvious.Despite numerous efforts,response to antibiotic re-sistance is considered to be inadequate,which is probably due to the lack of a clear roadmap.Here,we propose a“One Health”roadmap to combat antibiotic resistance in the environment through(1)understanding environmental resistome.The environmental gene pool has long been recognized as the single largest reservoir of both known and novel ARGs.(2)Standardizing ARG quantification.Systematic joint efforts based on standardized quantification are urgently needed to un-derstand the true tempospatial profiles of the environmental resistome.(3)Identifying mechanisms of resistome development.Horizontal gene transfer and co-selection have been recognized as the two main mechanisms contributing to the environmental resistome.(4)Establishing a risk-assessment framework.The first critical step for large-scale cost-effective targeted ARG management in the environment is the risk assessment to identify the priority ARGs for control.(5)Formulating regulatory standards.By correlating the environmental ARG profile with public health,we may identify the indicator ARGs that can be integrated into current environmental quality standards.(6)Developing control strategies.Systematic analysis of available control technologies is required to identify the most feasible ones to curtail the spread of ARGs in the environment.The proposed roadmap under the“One Health”framework provides a guide to tackle antibiotic resistance in the environment. | Liguan Li Tong Zhang | 2023 | mLife2023，2，3： | 0 |
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