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| 1 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 2 | Analysis of epidermal growth factor signaling in nasal mucosa epithelial cell proliferation involved in chronic rhinosinusitis显示文摘 | Li Yunchuan Li Lijuan Wang Tong Zang Hongrui An Yunsong Li Lifeng Zhang Junyi Wang Fujuan Zheng Yani | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 3 | Influence of Surface Nanocrystallization on Ti Ion Implantation of Pure Iron显示文摘In order to increase the depth or concentration of Ti ion implantation of pure iron, the surface mechanical attrition treatment(SMAT), which can fabricate a nanometer-grained surface layer without porosity and contamination in a pure iron plate, was used before ion implantation. Ti ion was implanted into the SMA treated sample and coarse-grained counterpart by using a metal vapor vacuum arc source implanter. The changing of depth and concentration of Ti was studied in a function of implantation time.By optical microscopy, transmission electron microscopy and X-ray diffraction, the grain size of the nano structured surface was studied. Micro-hardness, friction and wear behavior of nano surface layers were studied. By energy dispersive X-ray spectroscopy and Auger electron spectroscopy, the chemical composition and concentration of Ti ion in the surface implantation layer were studied. Experimental results showed that the concentration of Ti increased dramatically compared with untreated coarsegrained samples, which is attributed to the existence of higher density of defects(supersaturated vacancies, dislocations, non-equilibrium grain boundaries etc.) and compression stress field in the SMA treated nanocrystallined surface layer. The interaction between the defects and the implanted solute atoms leads to the increment of solid solubility. But the implantation depth showed inconspicuous change. It is shown that the ion range is just relevant to the energy and mass of the ion, dose of injection,the mass and density of target material. | Xu Li Yanli An Yinghui Wei Huayun Du Lifeng Hou Chunli Guo Hongbo Qu Yide Wang | 2015 | Journal of Materials Science & Technology2015，31，3： | 2 |
| 4 | One way of surface alloying treatment on iron surface based on surface mechanical attrition treatment and heat treatment显示文摘 | Huayun Du Yinghui Wei Wanming Lin Lifeng Hou Zengqing Liu Yanli An Wenfu Yang | 2009 | Applied Surface Science2009，，20： | 1 |
| 5 | Traffic light detection and recognition for autonomous vehicles显示文摘Traffic light detection and recognition is essential for autonomous driving in urban environments. A camera based algorithm for real-time robust traffic light detection and recognition was proposed, and especially designed for autonomous vehicles. Although the current reliable traffic light recognition algorithms operate well under way, most of them are mainly designed for detection at a fixed position and the effect on autonomous vehicles under real-world conditions is still limited. Some methods achieve high accuracy on autonomous vehicle, but they can't work normally without the aid of high-precision priori map. The authors presented a camera-based algorithm for the problem. The image processing flow can be divided into three steps, including pre-processing, detection and recognition. Firstly, red-green-blue(RGB) color space is converted to hue-saturation-value(HSV) as main content of pre-processing. In detection step, the transcendental color threshold method is used for initial filterings, meanwhile, the prior knowledge is performed to scan the scene in order to quickly establish candidate regions. For recognition, this article use histogram of oriented gradients(HOG) features and support vector machine(SVM) as well to recognize the state of traffic light. The proposed system on our autonomous vehicle was evaluated. With voting schemes, the proposed can provide a sufficient accuracy for autonomous vehicles in urban enviroment. | Guo Mu Zhang Xinyu Li Deyi Zhang Tianlei An Lifeng | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，1： | 1 |
| 6 | A Zener-Stroh crack interacting with an edge dislocation显示文摘A Zener-Stroh crack interacting with an edge dislocation is studied.The crack faces are assumed to be traction free.The applied 'generalized loading' for crack is the initial displacement jump and the intervention of the edge dislocation.Through decomposing the problem into two subsimple problems,using the superposition principle,its solution is obtained.To demonstrate both the validity of the solution and its potential application,two simple examples related to the crack stress intensity factors are pre... | Lifeng Ma,~(a) Jing Zhao,and Bo Ni S & V Lab,Department of Engineering Mechanics,Xi’an Jiaotong University,710049,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，2： | 0 |
| 7 | Relay navigation strategy study on intelligent drive on urban roads显示文摘In order to solve navigation problem of intelligent vehicle driving on urban roads and to achieve the navigation in intersection area, intersection transition area and section area. The relay navigation strategy and algorithm can solve the navigation problem of intelligent vehicle driving in typical urban roads such as intersection area, intersection transition area and section area, realizing seamless handover among different typical areas. Bezier curve function model was introduced to different typical areas, which solved the self-adaption recognition problem in different typical areas and revised positional accuracy with the help of cloud computing positioning service. In order to explain the strategy implement, an instance based on the strategy was adopted. Instance analysis indicates that as for the navigation problem in intersection area, intersection transition area and section area, if the relay navigation strategy is utilized, the self-adaption recognition problem in different typical areas can be handled. Based on the relay navigation strategy, the drive of intelligent vehicle on urban roads can effectively solve the self-adaption recognition problem in different typical areas in urban and further solve driving problems of intelligent vehicle of the same category in urban roads. | Gao Hongbo Zhang Xinyu An Lifeng Liu Yuchao Li Deyi | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，2： | 0 |
| 8 | Computational Investigation of the Interaction Between Hydrogen Atoms and an Intense Circularly Polarized Laser Field显示文摘The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a set of programs to facilitate the study of interactions between a circularly polarized laser and atomic hydrogen.These programs included only contribution from the bound states of the hydrogen atom.However,as the laser intensity increases,contribution from continuum states to the excitation and ionization processes becomes larger and can no longer be neglected.Furthermore,because the original code is not able to add this contribution directly due to its many disadvantages,a major upgrade of the code is required before including the contribution from continuum states in future.In this paper,first we deduce some important formulas for contribution of continuum states and present modifications and tests for the upgraded code in detail.Second we show some comparisons among new results,old results from the original codes and the available experimental data.Overall the new result agrees with experimental data well.Last we present our calculation of above-threshold ionization(ATI)rate and compare it with a pertubative calculation.The comparison shows that our nonperturbative calculation can also produce ATI peak suppression. | Lifeng Yang Wang Xu Qiren Zhang Wen Luo Qiangyan Pan Xiaolu Cai Gongtao Fan Yongjiang Li Benji Xu Zhe Yan Guangwei Fan Zhendong An | 2012 | Communications in Computational Physics2012，11，3： | 0 |
| 9 | Neuroprotective effect of Eleutheroside B on 1-methyl-4-phenylpyridinium ion-induced apoptosis in PC12 cells显示文摘Apoptosis and viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+)-induced injury were monitored by flow cytometry, following Annexin V-propidium iodide double labeling, and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, respectively. The release of lactate dehydrogenase, superoxide dismutase activity and levels of malondialdehyde were determined by UV spectrophotometry. The changes in mitochondrial membrane potential and the intracellular concentration of calcium were determined by flow cytometry, and the activity of caspase-3 was monitored by western blot. According to cell viability and apoptosis studies, MPP+-induced apoptosis in PC12 cells was inhibited in the presence of 10 μg/mL of Eleutheroside B. Our results indicate that the neuroprotective effect of Eleutheroside B, following MPP+-induced apoptosis in PC12 cells, involves increasing the anti-oxidative stress capacity of cells, maintaining the high-energy state of mitochondrial membrane potential, reducing intracellular calcium concentration and inhibiting caspase-3 activity. | Fang Lu Yang Dong Laijun Deng Shumin Liu Shihui Zhou Lifeng An Bo Tang | 2011 | Neural Regeneration Research2011，6，18： | 0 |
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