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| 1 | cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment显示文摘为模仿减少的严肃环境的一个新奇基于地面的模型广泛地在许多地里被使用了的抗磁的悬浮。在这研究,一个专辑设计了超导的磁铁,它能生产三个明显的严肃层次(0, 1,和 2 g ) ,也就是高的磁电机重力的环境(HMGE ) ,被用来模仿空间严肃环境。造骨细胞基因表示侧面上的 HMGE 的效果被 microarray 调查。对抗磁的悬浮环境(0 g ) 敏感的基因,严肃变化,和高磁场变化根据典型房间功能被排序。作为细胞内部的忍受负担的结构,细胞骨架在严肃感觉起一个重要作用。因此, 13 细胞骨架相关的基因根据 microarray 分析的结果被选择,并且这些基因的表情被发现被即时 PCR 在 HMGE 下面改变。基于 PCR 结果, WASF2 的表情(是蛋白质家庭,成员 2 ) , WIPF1 (WAS/WASL 交往蛋白质家庭,成员 1 ) , paxillin,和 talin 1 被西方的污点试金进一步识别。结果显示了那 WASF2, WIPF1 对改变的严肃层次,和 talin 更敏感 1 并且 paxillin 对磁场和严肃变化敏感。我们的调查结果证明 HMGE 能影响造骨细胞基因表示侧面和细胞骨架相关的基因表示。mechanosensitive 基因的鉴定可以提高我们的理解到 microgravity 导致的骨头损失的机制并且可以为阻止并且对待骨头损失或骨质疏松症提供一些潜在的目标。 | Airong Qian Shengmeng Di Xiang Gao Wei Zhang Zongcheng Tian Jingbao Li Lifang Hu Pengfei Yang Dachuan Yin Peng Shang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 8 |
| 2 | Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems显示文摘Two sequencing batch reactors(SBRs) were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater(USBR), and the other fed with sterilized municipal wastewater(SSBR). Respirometric assays and fluorescence in situ hybridization(FISH) results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate(AUR) and nitrite utilization rate(NUR) of the unsterilized influent were 0.32 ± 0.12 mg NH4+-N/(L·hr) and0.71 ± 0.18 mg NO2--N/(L·hr). Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria(AOB) and nitrite oxidizing bacteria(NOB) of the USBR was 0.08 g AOB/(g AOB·day) and 0.20 g NOB/(g NOB·day) respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors. | Lifang Yu Ren Li Robert Delatolla Ru Zhang Xiuling Yang Dangcong Peng | 2018 | Journal of Environmental Sciences2018，30，12： | 7 |
| 3 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 4 | A New Species of the Genus Thermophis(Serpentes: Colubridae) from Shangri-La, Northern Yunnan, China, with a Proposal for an Eclectic Rule for Species Delimitation显示文摘The hot-spring snakes, Thermophis, were previously known only from the Tibet Autonomous Region and Western Sichuan, China. During the past two years, three adult hot-spring snakes(2 females, 1 male) were sampled in Shangri-La, northern Yunnan, China, thus expanding their known distribution region towards the southeast. This site is the southeastern-most corner of the Tibetan Plateau and the southernmost tip of the Hengduan Mountains(Mts.). Phylogenetic analysis of mitochondrial(mt) and nuclear(n) DNA segments suggested that the three specimens belong to the genus of Thermophis. Morphologically, the new species is more similar to T. zhaoermii. However, it is distinguished from T. zhaoermii in the number of maxillary teeth(15), distance between the two eyes/head width, rostral width/height, mental width/height, in one character limited to female: head width/length, and in four characters restricted to male: occurrence of the reduction from 10 to 8(8 to 6, 6 to 4) scales in each dorsal row on the tail. There are differences in morphology, genetics(mt DNA, n DNA), and geography between the putative new species and T. zhaoermii, the new species meets our proposed eclectic and feasible 'four-differences' rule. | Lifang PENG Changhu LU Song HUANG Peng GUO Yaping ZHANG | 2014 | Asian Herpetological Research2014，5，4： | 4 |
| 5 | A New Species of the Genus Sinomicrurus Slowinski,Boundy and Lawson,2001 (Squamata:Elapidae) from Hainan Province,China显示文摘A new species of the coral snake genus Sinomicrurus is described based on four specimens from southern Hainan Island(three specimens from Tianchi,Jianfengling National Nature Reserve,one specimen from Diaoluoshan National Nature Reserve),Hainan Province,China.Morphologically,the new species is rather similar to Sinomicrurus kelloggi.However,it is distinct from S.kelloggi by the pattern on the head,the head length,head length/width,the number of infralabial scales,number of bands on dorsal body,and number of blotches on the belly. | Lifang PENG Lijun WANG Li DING Yiwu ZHU Jian LUO Diancheng YANG Ruyi HUANG Shunqing LU Song HUANG | 2018 | Asian Herpetological Research2018，9，2： | 3 |
| 6 | A New Species of the Genus Achalinus from Huangshan, Anhui, China(Squamata: Xenodermidae)显示文摘A new species of the genus Achalinus is described based on five specimens collected from the villages of Huangjialing and Fuxi, Huangshan, Anhui, China. It can be morphologically differentia ted from all the other species in Achalinus except for A. spinalis and A. werneri by the presence of a dotted black streak in the middle of the subcaudal. It can be distinguished from A. spinalis in that its two anterior temporals are in contact with eye, and A. werneri by its light brown flanks. The phylogenetic rela tionship of Achalinus was reconstructed using the mitochondrial locus of cytochrome coxidase subunit 1(CO1). The five new specimens form a monophyletic clade with strong support. The uncorrected p-dista nces between the new species and other representatives of Achalinus range from 13.6% to 21.7%. The recognition of the new species increases the number of described Achalinus species to 14. | Ruyi HUANG Lifang PENG Lei YU Tianqi HUANG Ke JIANG Li DING Jinkang CHANG Diancheng YANG Yuhao XU Song HUANG | 2021 | Asian Herpetological Research2021，12，2： | 3 |
| 7 | Intraspecific Polymorphism of Rice Frog,Fejervarya multistriata(Anura: Ranidae),in Lingnan,Huangshan,China显示文摘Many anuran species exhibit striking color and/or pattern polymorphisms.We sampled 599 adult rice frogs,Fejervarya multistriata,from a rice paddy in the periphery of the Lingnan Nature Reserve(Huangshan,Anhui).We recognized ten morphs based on three relatively stable and distinct morphological characters: dorsal ground color(green or gray),middorsal stripe(absence,wide,or narrow),occipital rusty spot(absence or presence).The grey individuals are more common and larger than the green individuals(frequency 88.1 vs.11.9%,respectively) and(SVL 39.4–36.6 vs.35.7–34.6 mm,respectively).There is a higher proportion of individuals with a middorsal stripe(59.7%) while absence of the occipital rusty spot is more common in the population(82.3%).We expect additional studies in different habitat types would help build our understanding of the relationship between color polymorphism and habitat,geography,and climate. | Diancheng YANG Lifang PENG Jingcheng XU Song HUANG | 2017 | Asian Herpetological Research2017，18，1： | 2 |
| 8 | Analysis of global gene expression profiles to identify differentially expressed genes critical for embryo development in Brassica rapa显示文摘 | Yu Zhang Lifang Peng Ya Wu Yanyue Shen Xiaoming Wu Jianbo Wang | 2014 | 2014 (4-5)2014，，4： | 1 |
| 9 | A service innovation evaluation framework for tourism e-commerce in China based on BP neural network显示文摘 | Lifang Peng Lingling Lai | 2014 | Electronic Markets2014，，1： | 1 |
| 10 | Effect and mechanism of AR-6 in experimental rheumatoid arthritis显示文摘 | Shi-xue Sun Yun-man Li Wei-rong Fang Peng Cheng Lifang Liu Fengwen Li | 2010 | Clinical and Experimental Medicine2010，，2： | 1 |
| 11 | 2013~2017年中国空气质量改善与早产疾病负担改变显示文摘Preterm birth(PTB)is a leading cause of perinatal mortality and morbidity worldwide[1].Since maternal and fetal health protection has been included in the United Nations Sustainable Development Goals,identification of modifiable risk factors for PTB is particularly crucial.The Global Burden of Disease(GBD)Study 2019 recognized fine particulate matter(PM2.5)pollution as a risk factor for decreased gestational age and low birth weight. | Yixuan Jiang Yuan He Shenpeng Wu Renjie Chen Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Xudong Dong Hongping Zhang Lifang Jiang Huichu Li Yixiang Zhu Cong Liu Weidong Wang Xia Meng Tao Pei Ci Song Aaron Cohen Xu Ma Jing Cai Haidong Kan | 2022 | Science Bulletin2022，67，9： | 1 |
| 12 | Influence of rainfall-induced diabatic heating on southern rainfall-northern haze over eastern China in early February 2023显示文摘In early February 2023,there was severe haze on the North China Plain(NCP)that was contemporaneous with heavy rainfall over southern China,which was known as southern rainfall-northern haze(SR-NH).Based on observational and reanalysis data,the meteorological causes of this SR-NH event are investigated in this study using correlation analysis,dynamic diagnostics and numerical experiments.The results show that the anticyclonic anomaly in the Pacific Northwest(also referred to as the northeast Asian anomalous anticyclone)is responsible for the SR-NH.On the one hand,this anticyclonic anomaly leads to persistent rainfall over southern China by causing strong ascending motion in conjunction with an anomalous cyclone over the Chinese mainland and transporting large amounts of water vapor there.On the other hand,it weakens the climatological northerly winds of the NCP through the southeasterly flow,worsening the horizontal diffusion conditions of pollutants.Additionally,the atmospheric stability and relative humidity over the NCP are significantly increased by this anticyclonic anomaly.These conditions result in higher PM2.5concentrations over the NCP.Additional results suggest that this anticyclonic anomaly is related to diabatic heating released by rainfall in southern China,which not only intensifies the rainfall process there(with a contribution of 11.5%)but also induces an anticyclonic anomaly in the upper troposphere of the Pacific Northwest(i.e.,200 hPa).The rainfall-related anticyclonic anomaly reinforces the anticyclonic anomaly in the Pacific Northwest caused by large-scale circulation(with a contribution of 27%)and thus affects haze over the NCP.This study provides a new reference for understanding the contribution of rainfall in southern China to haze over the NCP. | Xiadong AN Wen CHEN Chun LI Lifang SHENG Weihang ZHANG Shangfei HAI Peng HU | 2023 | Science China Earth Sciences2023，66，11： | 0 |
| 13 | Brain circuits for retching-like behavior显示文摘Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body.The nucleus of the solitary tract(NTS)is important for initiating these responses.However,the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses.Here,we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses.Among these,we identified Calbindin1-positive(Calb1^(+))NTS neurons that are molecularly distinct from Tac1^(+)neurons.These Calb1^(+)neurons are critical for nausea and retching induced by cereulide;an emetic toxin secreted by Bacillus Cereus.Strikingly,we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1^(+)NTS neurons,a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A.Together,our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior.These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins. | Lifang Huo Zhimin Ye Meiling Liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong Congping Shang | 2024 | National Science Review2024，11，1： | 0 |
| 14 | Research on the Seismic Activity of the Lower Yangtze River-South Yellow Sea Seismic Zone显示文摘The Lower Yangtze River-South Yellow Sea Seismic Zone,located at the southeast of the Northern China Seismic Zone, characterized by moderate-strong earthquakes, is an intensive earthquake zone,which is controlled by a series of faults within the Lower Yangtze River-South Yellow Sea Seismic Zone. This article counts and calculates the bvalue,V 4 and energy density value of medium-small earthquakes by taking full advantage of the latest data from regional seismic stations,reviews data of historical earthquakes and seismic structure,and discusses the relationship between spatial distribution of the b-value, historical strong earthquakes and spatial distribution of energy density of medium-small earthquakes,and further investigates the seismic activity of the Lower Yangtze River- South Yellow Sea Seismic Zone. This article obtains seismic activity parameters of the Lower Yangtze River-South Yellow Sea Seismic Zone as calculation parameters for probabilistic seismic hazard analysis,and discusses the trend of this seismic zone in the next one hundred years and deduces the potential seismic hazard region within this seismic zone,which provides references and methods for long-term prediction on seismic activity. The research results are significant to seismic zoning, seismic safety evaluation of engineering sites and long-term prediction of seismic activity. | Xie Zhuojuan Lv Yuejun Peng Yanju Lan Jingyan Zhang Lifang | 2013 | Earthquake Research in China2013，27，2： | 0 |
| 15 | Methods for Estimating Mean Annual Rate of Earthquakes in Moderate and Low Seismicity Regions显示文摘Two kinds of methods for determining seismic parameters are presented,that is,the potential seismic source zoning method and grid-spatially smoothing method. The Gaussian smoothing method and the modified Gaussian smoothing method are described in detail, and a comprehensive analysis of the advantages and disadvantages of these methods is made. Then,we take central China as the study region,and use the Gaussian smoothing method and potential seismic source zoning method to build seismic models to calculate the mean annual seismic rate. Seismic hazard is calculated using the probabilistic seismic hazard analysis method to construct the ground motion acceleration zoning maps. The differences between the maps and these models are discussed and the causes are investigated. The results show that the spatial smoothing method is suitable for estimating the seismic hazard over the moderate and low seismicity regions or the hazard caused by background seismicity; while the potential seismic source zoning method is suitable for estimating the seismic hazard in well-defined seismotectonics. Combining the spatial smoothing method and the potential seismic source zoning method with an integrated account of the seismicity and known seismotectonics is a feasible approach to estimate the seismic hazard in moderate and low seismicity regions. | Peng Yanju Zhang Lifang Lv Yuejun Xie Zhuojuan | 2012 | Earthquake Research in China2012，26，3： | 0 |
| 16 | Analysis on Completeness of Small Earthquake Data in the Northeast Seismic Zone and Its Influence on Seismicity Parameters显示文摘Taking the northeast seismic zone as an example and based on the magnitude-frequency distribution principles of the G-R relationship and the study on the temporal and spatial distribution characteristics of the minimum magnitude of completeness M C in each time interval,this paper makes a statistical analysis on the seismicity parameters of the research area and explores the influence of the completeness of small earthquake data on the seismicity parameters and seismic hazard analysis.It shows that the completeness analysis of the regional small earthquakes data provides a possible means for obtaining more accurate seismicity parameters that can better represent the actual regional seismicity level for areas of low seismicity.The research methods of this article and its conclusion can be used as a reference for the completeness analysis of earthquake data and seismic activity research. | Xie Zhuojuan Lv Yuejun Peng Yanju Zhang Lifang | 2013 | Earthquake Research in China2013，27，3： | 0 |
| 17 | The Method of Spatially Smoothed Seismicity Parameters in Consideration of Seismotectonic Background and Its Application to Seismic Hazard Estimation显示文摘In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids, and some parameters (e.g. b-value, M0, Mu, azimuth and M-L relationship) for each seismotectonic model were assigned. Secondly, using elliptical smoothing based on a seismotectonic background model, the statistical earthquake incidence rate in each grid is successively calculated. Lastly, the relevant ground motion attenuation relationship is chosen to assess seismic hazard of general sites. The maps for the distribution of horizontal peak ground acceleration with 10% probability of exceedance in 50 years were obtained by using the seismic hazard analysis method based on grid source. This seismicity model simplifies the methodology of probabilistic seismic hazard analysis, especially appropriate for those places where seismic tectonics is not yet clearly known. This method can provide valuable references for seismic zonation and seismic safety assessment for significant engineering projects. | Zhang Lifang Lv Yuejun Peng Yanju Ma Xiaoling Cui Manfeng | 2013 | Earthquake Research in China2013，27，1： | 0 |
| 18 | Clinical diagnosis and treatment of COVID-19 complicated with acute renal Injury:a case report显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a new disease that represents the current pandemic.Since its origin in China in December 2019,there is convincing evidence that the new SARS-CoV-2 is a highly transmissible virus.Kidney is one of the main target infected by COVID-19.We report a confirmed case of COVID-19 complicated with acute renal Injury during hospitalization.A67-year-old female patient,a farmer,had a history of close contact with COVID-19 patient.The patient developed acute kidney injury(AKI)at afternoon on the 5 th day of hospitalization(9 th day of onset),and then the patient was given high-resolution computed tomography(CRRT)for treatment.Patient outcome was clinical cure.Kidney injury has great role in screening of the evaluation of disease condition and prognosis.In additon,this case highlights the importance of CRRT for servere patients. | Xu Lei Zhang Haiming Huang Changfa Lin Sha Chen Keqin He Lifang Peng Shuang Fang Zhixiong | 2021 | 实用休克杂志(中英文)2021，5，1： | 0 |
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