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| 1 | Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats显示文摘AIM: To evaluate the preventive effect of Ginkgo bilobaextract (GbE) on ethanol-induced gastric mucosal injuries in rats.METHODS: Female Wistar albino rats were used for the studies. We randomly divided the rats for each study into five subgroups: normal control, experimental control, and three experimental groups. The gastric ulcers were induced by instilling 1 mL 50% ethanol into the stomach. We gaveGbE 8.75, 17.5, 26.25 mg/kg intravenously to the experimental groups respectively 30 min prior to the ulcerative challenge. We removed the stomachs 45 min later. The gastric ulcers,gastric mucus and the content of non-protein sulfhydryl groups (NP-SH), malondialdehyde (MDA), c-Jun kinase (JNK) activity in gastric mucosa were evaluated. The amount of gastric juice and its acidity were also measured. RESULTS: The findings of our study are as follows: (1)GbE pretreatment was found to provide a dose-dependent protection against the ethanol-induced gastric ulcers in rats; (2) the GbE pretreatment afforded a dose-dependent inhibition of ethanol-induced depletion of stomach wall mucus, NP-SH oontents and increase in the lipid peroxidation (increase MDA) in gastric tissue; (3) gastric ulcer induced by ethanolproduced an increase in JNK activity in gastric mucosawhich also significantly inhibited by pretreatment with GbE;and (4) GbE alone had no inhibitory effect on gastric secretionin pylorus-ligated rats.CONCLUSION: The finding of this study showed that GbE significantly inhibited the ethanol-induced gastric lesions in rats. We suggest that the preventive effect of GbE may be mediated through: (1) inhibition of lipid peroxidation;(2) preservation of gastric mucus and NP-SH; and (3)blockade of cell apoptosis. | Sheng-Hsuan Chen Yu-Chih Liang Jane CJ Chao Li-Hsueh Tsai Chun-Chao Chang Chia-Chi Wang Shiann Pan | 2005 | World Journal of Gastroenterology2005，11，24： | 6 |
| 2 | A rapid spectrophotometric determination of persulfate anion in ISCO显示文摘 | Liang CJ Huang C F Mohanty N | 2008 | Chemosphere2008，73，9： | 1 |
| 3 | Influence of pH on persulfate oxidation of TCE at ambient temperatures显示文摘 | Liang CJ Wang ZS Bruell CJ | 2007 | Chemosphere2007，66，： | 1 |
| 4 | Chemotherapy of human carcinoma xenografts during pulsed magnetic field exposure显示文摘 | Hannan CJ Jr Liang Y Allison JD | 1994 | Anticancer Res1994，14，4： | 1 |
| 5 | Mode Analysis of Surface Plasmon Metal-Dielectric-Metal Nanowire Array Waveguide at Sub- Wavelength Scale显示文摘 | TianJ P Liang XJ Zhang CJ | 2013 | Eur Phys] D2013，67，： | 1 |
| 6 | Magnolol reduced TNF-a-induced vascular cell adhesion molecule-1 expression in endothelial cellsvia JNK/ p38 and NF-B signaling pathways显示文摘 | Liang CJ Lee CW Sung HC | 2014 | Am J Chin Med2014，42，3： | 1 |
| 7 | Interleukin 28B genetic polymorphisms and viral factors help identify HCV genotype -1 patients who benefit from 24 - week pegylated interferon plus ribavirin therapy显示文摘 | LlU CH LIANG CC LlU CJ | 2012 | Antivir Ther2012，17，3： | 1 |
| 8 | Magnolol reduced TNF-a-in- duced v,~scular cell adhesion molecule-1 expression in endothelial cells via JNK/p38 and NF-KB signaling pathways 显示文摘 | Liang CJ Lee CW Sung HC | 2014 | Am J Chin Med2014，42，3： | 1 |
| 9 | Multiple risk factors of nasopharyngeal carcinoma:Epstein-Barr virus,malarial infection,cigarette smoking and familial tendency显示文摘 | Chen CJ Liang KY Chang YS | 1990 | Anticancer Res1990，10，2： | 1 |
| 10 | First-trimester uterine rupture from a placenta percreta:a case report显示文摘 | Liang HS Jeng CJ Sheen TC | 2003 | J Repred Med2003，48，6： | 1 |
| 11 | Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance显示文摘 | Kok MS Chi CJ Liang YW | 2004 | Hum Reprod2004，19，： | 1 |
| 12 | Comparison of CYFRA 21-1 and tissue polypeptide specific antigen (TPS) for detecting nasopharyngeal carcinoma 显示文摘 | Liu FY Liang JA | 2002 | Anticancer Res2002，22，6： | 1 |
| 13 | Perinatal transmission of human papillomavirus in itlfants: relationship between infection rate and mode of delivery显示文摘 | Tseng CJ Liang CC Soong YK | 1998 | Obstet Gynecol1998，91，1： | 1 |
| 14 | Human infection with West Nile virus, Xinjiang, China, 2011 显示文摘 | Lu Z Fu SH Cao L Tang CJ Zhang S Li ZX Tusong M Yao XH Zhang IlL Wang PY Wumaier M Yuan XY Li MH Zhu CZ Fu LP Liang GD | 2014 | Emerg Infect Dis2014，20，8： | 1 |
| 15 | In vitro cytotoxicity against human cancer cell lines during pulsed magnetic field exposure显示文摘 | LIANG Y ALLISON JR | 1994 | Anticancer Res1994，14，： | 1 |
| 16 | Pigment epithelium-de-rived factor reduces the PDGF-induced migration and prolifera-tion of human aortic smooth muscle cells through PPARy acti-vation显示文摘 | Wang SH Liang CJ Wu JC | 2012 | Int J Biochem Cell Biol2012，44，2： | 1 |
| 17 | Evolving window orthogonal projections method for two-way data resolution显示文摘 | Jiang JH Liang YZ | 1999 | Analysis1999，，： | 1 |
| 18 | OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi显示文摘 | Luke CJ Carner K Liang X | 1997 | J Infect Dis1997，75，1： | 1 |
| 19 | Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibro- blasts via inhibition of the p38/Smad3 pathway显示文摘 | Liang CJ Yen YH Hung LY | 2013 | Biochem Pharmacol2013，85，11： | 1 |
| 20 | Perinatal transmission of hmnan papillomavirus in infants: relationship between infection rate and mode of delivery显示文摘 | Tseng CJ Liang CC Soong YK | 1998 | Obstet Gynecol1998，91，1： | 1 |
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