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| 1 | Nonlinear optical endomicroscopy for label-free functional histology in vivo显示文摘This manuscript reports on the first two-photon,label-free,metabolic imaging of biological tissues in vivo at histological resolution on an extremely compact,fiber-optic endomicroscopy platform.This system provides new opportunities for performing noninvasive and functional histological imaging of internal organs in vivo,in situ and in real time.As a routine clinical procedure,traditional histology has made significant impacts on medicine.However,the procedure is invasive and time consuming,suffers random sampling errors,and cannot provide in vivo functional information.The technology reported here features an extremely compact and flexible fiber-optic probe~2 mm in diameter,enabling direct access to internal organs.Unprecedented two-photon imaging quality comparable to a large bench-top laser scanning microscope was achieved through technological innovations in double-clad fiber optics and miniature objective lenses(among many others).In addition to real-time label-free visualization of biological tissues in situ with subcellular histological detail,we demonstrated for the first time in vivo two-photon endomicroscopic metabolic imaging on a functioning mouse kidney model.Such breakthroughs in nonlinear endoscopic imaging capability present numerous promising opportunities for paradigm-shifting applications in both clinical diagnosis and basic research. | Wenxuan Liang Gunnsteinn Hall Bernhard Messerschmidt Ming-Jun Li Xingde Li | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion显示文摘酸的微型环境,特别地酸察觉到的离子隧道 1a (ASIC1a ) ,被报导了象移植一样支持癌房间增长。在这研究,我们在胃的癌(GC ) 的移植和侵略上探索了 ASIC1a 的效果。ASIC1a 表示层次被 immunohistochemistry 从 16 个病人在配对的 GC 和邻近的正常纸巾检验。反向的抄写即时 PCR 和 immunoblotting 被进行与 ASIC1a 小发卡 RNA (shRNA ) 在 transfection 以后在 GC 房间线 AGS 估计 ASIC1a 表示层次。创伤愈合和 transwell 侵略试金被利用检测转移和侵略追随者 ASIC1a silencing。肿瘤形成被用来在 vivo 在 tumorigenicity 检测 ASIC1a 的角色。ASIC1a 表示水平在与非转移相比显示出手术后的转移的 GC 纸巾和非肿瘤纸巾是显著地更高的,这被发现。而且,有 shRNA 的 ASIC1a 的 silencing 显著地下面调整的 ASIC1a 表示和减少的 GC 房间移植和侵略。中等酸的细胞外的环境禁止了 GC 房间生存能力。而且, ASIC1a shRNA 在 vivo 引起了 tumorigenicity 的抑制。我们的学习是 attenuating 的第一份报告在 vitro 并且在由压制 ASIC1a 的 vivo 的 GC 的恶意的显型,并且建议一条新奇途径学习在 ASIC 和 GC 房间移植和侵略之间的关系。 | Xin Chen Xue Sun Zhe Wang Xiaojun Zhou Lu Xu Feng'e Li Xingding Zhang Ji'an Pan Lin Qi Haixin Qian Zhongqi Mao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 3 |
| 3 | Preparation of natural brucite nanofibers by the dispersion method显示文摘The preparation of natural brucite nanofibers through dispersion by the wet process is described. The test results indicate that brucite fibers can be well dispersed by using sodium dioctyl sulfosuccinate (OT) as the dispersant at a dispersant/fiber mass ratio of 0.15:1, dispersing for 30 min at a water/solid mass ratio of 20:1. The prepared nanofibers were characterized with X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscope (TEM). It is shown that the prepared single brucite nanofiber is around 30 nm in diameter and the talus of the nonsingle brucite nanofibers is about 50-150 nm in diameter. Natural brucite mineral fibers were treated by the dispersion method to obtain nanomaterials. These fibers have significant advantages over artificial nanofibers both in yield and in cost. | Li Xu Wen Ni Wenping Li Xingde Liu Hailong Yang Xiaoguang Yang | 2008 | Journal of University of Science and Technology Beijing2008，15，4： | 2 |
| 4 | High-Speed optical delay line for optical coherence tomography显示文摘 | Liu Xiumei Cobb M J Li Xingde | 2004 | Optics Letters2004，29，1： | 1 |
| 5 | Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study显示文摘 | Michael J. Cobb Joo Ha Hwang Melissa P. Upton Yuchuan Chen Brant K. Oelschlager Douglas E. Wood Michael B. Kimmey Xingde Li | 2010 | Gastrointestinal Endoscopy2010，，： | 1 |
| 6 | Imaging needle for optical coherence tomography 显示文摘 | Xingde Li Christian Chudoba Tony Ko | 2000 | Optical Let- ters2000，25，20： | 1 |
| 7 | Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study显示文摘 | Michael J. Cobb Joo Ha Hwang Melissa P. Upton Yuchuan Chen Brant K. Oelschlager Douglas E. Wood Michael B. Kimmey Xingde Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 8 | Edge Ohmic Heating Experiment on HT-6M Tokamak显示文摘An improved ohmic confinement has been achieved on HT-6M tokamak after application of edge ohmic heating pulse which makes plasma current rapidly ramp up(0.4 ms)in a ramp rate of 12 MA/s.The improved ohmic confinement phase is characterized by(a)energy and particle confinement time increase,(b)non-symmetric increased density ne,(c)reduced Hαradiation,(d)increased Te and steeper Te,ne profile at the edge.The results from soft x-ray sawteeth inversion radius andβ_(p)+l_(i)/2 implied the anomalous current penetration. | GAO Xiang FAN Shuping LI Jian’gang MENG Yuedong LUO Jiarong YIN Fhxian ZENG Lei DING LianchengLIN Bili ZHANG Wei HAN Yuqing TONG Xingde LUO Lanchang GONG Xianzu JIANG Jiaguang WU Mingjun YIN Fei | 1994 | Chinese Physics Letters1994，11，3： | 0 |
| 9 | BME Frontiers: A Platform for Engineering the Future of Biomedicine显示文摘With immense enthusiasm, we introduce Biomedical Engineering (BME) Frontiers, the third addition to the family ofScience Partner Journals. The launch of BME Frontiers follows a year of intense preparation. As an open-access, peerreviewed academic journal, BME Frontiers covers basicresearch in relevant fields, as well as preclinical and clinicalinvestigations. The content will include innovative fundamental and translational concepts, mechanisms, materials,devices, systems, processes, and methods. BME Frontiers willalso serve as a platform for catalyzing forward-looking discussions about the field and will include perspectives ontraining and educating the future BME workforce. | Xingde Li Guoqi Zhang Yuguo Tang | 2020 | Biomedical Engineering Frontiers2020，1，1： | 0 |
| 10 | Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals显示文摘All-fiber-optic photometry system based on a multi-branch fiber bundle has achieved,for the first time,simultaneous optogenetic manipulation and dual-color recording of neuronal Ca^(2+) or neurotransmitter signals in freely moving animals,providing a powerful tool for comprehensive analysis of neural circuit function and the study of neurological diseases. | Xingde Li | 2023 | Opto-Electronic Advances2023，6，7： | 0 |
| 11 | Recent Development of OCT Technologies显示文摘Optical coherence tomography (OCT) was first reported about 18 years ago. OCT was originally developed for imaging the relatively transparent eye tissue, and later applied | Xingde Li Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205 | 2009 | 生物物理学报2009，25，S1： | 0 |
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