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| 1 | Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF,and the neutralization of miR-150 attenuate tumor development显示文摘Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic factor.During tumor development,TAMs secrete VEGF and other factors to promote angiogenesis;thus,anti-treatment against TAMs and VEGF can repress cancer development,which has been demonstrated in clinical trials and on an experimental level.In the present work,we show that miR-150 is an oncomir because of its promotional effect on VEGF.MiR-150 targets TAMs to up-regulate their secre-tion of VEGF in vitro.With the utilization of cell-derived vesicles,named microvesicles(MVs),we transferred an-tisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis.There-fore,we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel,natu-ral,microvesicle-based method for the transfer of nucleic acids. | Yuchen Liu Luming Zhao Dameng Li Yuan Yin Chen-Yu Zhang Jing Li Yujing Zhang | 2013 | Protein & Cell2013，4，12： | 18 |
| 2 | STUDY ON MECHANISM OF ARC-EXCITED ULTRASONIC显示文摘0INTRODUCTIONAnelectricalarccanbeidentifiedasadynamicresistanceinanarcweldingcircuit.Itistriedsucesfulyintungsteninertgasarcw... | Wu Minsheng Wang Zhengxian Li Luming Sun Diqing Duan Xiangyang Department of Mechanical Engineering, Qinghua University | 1999 | Chinese Journal of Mechanical Engineering1999，12，1： | 8 |
| 3 | The recent advances in self-powered medical information sensors显示文摘Monitoring various medical information distributed throughout the body is of great importance in early clinic diagnosis and treatment of disease.To discover abnormal medical signals and find their causes in good time,the human body should be monitored continuously and accurately.To meet the requirements,various battery-less and self-powered information acquisition techniques are invented.In this review,the recent advances in self-powered medical information sensors(SMIS)with different functions,structure design,and electric performance are summarized and discussed.The SMIS mainly involves triboelectric nanogenerator(TENG),piezoelectric nanogenerator(PENG),pyroelectric nanogenerator(PyNG)/thermoelectric generator(TEG)and solar cell.Additionally,this review also analyzed the remaining challenges and prospected the development direction of SMIS in future. | Luming Zhao HuLi Jianping Meng Zhou Li | 2020 | InfoMat2020，2，1： | 7 |
| 4 | Astronaut mass measurement using linear acceleration method and the effect of body non-rigidity显示文摘Astronaut's body mass is an essential factor of health monitoring in space.The latest mass measurement device for the International Space Station (ISS) has employed a linear acceleration method.The principle of this method is that the device generates a constant pulling force,and the astronaut is accelerated on a parallelogram motion guide which rotates at a large radius to achieve a nearly linear trajectory.The acceleration is calculated by regression analysis of the displacement versus time trajectory and the body mass is calculated by using the formula m=F/a.However,in actual flight,the device is instable that the deviation between runs could be 6-7 kg.This paper considers the body non-rigidity as the major cause of error and instability and analyzes the effects of body non-rigidity from different aspects.Body non-rigidity makes the acceleration of the center of mass (C.M.) oscillate and fall behind the point where force is applied.Actual acceleration curves showed that the overall effect of body non-rigidity is an oscillation at about 7 Hz and a deviation of about 25%.To enhance body rigidity,better body restraints were introduced and a prototype based on linear acceleration method was built.Measurement experiment was carried out on ground on an air table.Three human subjects weighing 60-70 kg were measured.The average variance was 0.04 kg and the average measurement error was 0.4%.This study will provide reference for future development of China's own mass measurement device. | YAN Hui LI LuMing HU ChunHua CHEN Hao HAO HongWei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 6 |
| 5 | shRNA-mediated Slc38a1 silencing inhibits migration, but not invasiveness of human pancreatic cancer cells显示文摘Objective:Early metastasis is a major biological feature of pancreatic cancer.The current study examined whether silencing Slc38a1,a gene involved in energy metabolism,using short hairpin RNA(shRNA)could inhibit the growth,migration,and invasiveness of pancreatic cancer cells.Methods:A series of Slc38a1 shRNAs were designed and cloned into the pGPU6/GFP/Neo vectors.An shRNA with the most efficacious inhibitory action on SCL38A1 expression(65%inhibition)upon screening in DH5αbacteria was used to transfect SW1990 human pancreatic cancer cells.Cell growth,migration,and invasiveness were examined using cell counting kit-8,Boyden chamber without and with Matrigel,respectively.Results:Transfection of SW1990 cells with the SLCs38A1 shRNA significantly decreased the proliferation(P<0.0001)and migratory potential(by 46.7%,P=0.0399)of the cancer cells.Invasiveness,however,was not affected.Conclusions:Inhibiting Slc38a1 using shRNA technology could decrease the growth and migration of representative pancreatic cancer cells.However,the fact that invasiveness was not affected suggested that SLC38A1 is unlikely to be responsible for early metastasis. | Jing Xie Zhen Chen Luming Liu Ping Li Xiaoyan Zhu Huifeng Gao Zhiqiang Meng | 2013 | Chinese Journal of Cancer Research2013，25，5： | 5 |
| 6 | Tunable and switchable harmonic h-shaped pulse generation in a 3.03 km ultralong mode-locked thulium-doped fiber laser显示文摘We experimentally demonstrated a type of tunable and switchable harmonic h-shaped pulse generation in a thulium-doped fiber(TDF) laser passively mode locked by using an ultralong nonlinear optical loop mirror.The total cavity length was ~3.03 km, the longest ever built for a TDF laser to our best knowledge, which resulted in an ultralarge anomalous dispersion over -200 ps^2 around the emission wavelength. The produced h-shaped pulse can operate either in a fundamental or in a high-order harmonic mode-locking(HML) state depending on pump power and intra-cavity polarization state(PS). The pulse duration, no matter of the operation state, was tunable with pump power. However, pulse breaking and self-organizing occurred, resulting in high-order HML,when the pump power increased above a threshold. At a fixed pump power, the order of HML was switchable from one to another by manipulating the PS. Switching from the 8 th up to the 48 th order of HML was achieved with a fixed pump power of ~4.15 W. Our results revealed the detailed evolution and switching characteristics of the HML and individual pulse envelope with respect to both the pump power and PS. We have also discussed in detail the mechanisms of both the h-shaped pulse generation and the switching of its HML. This contribution would be helpful for further in-depth study on the underlying dynamics of long-duration particular-envelope pulses with ultralarge anomalous dispersion and ultralong roundtrip time. | JUNQING ZHAO LEI LI LUMING ZHAO DINGYUAN TANG DEYUAN SHEN LEI SU | 2019 | Photonics Research2019，7，3： | 4 |
| 7 | Proteasomal deubiquitinase UCH37 inhibits degradation of β-catenin and promotes cell proliferation and motility显示文摘The ubiquitin–proteasome system degrades most cellular proteins in eukaryotes.UCH37,also known as UCH-L5,is a deubiquitinase binding to Rpn13,a receptor for ubiquitinated substrates in the 26 S proteasome.But,it remains unclear how UCH37 influences the proteasomal degradation of the ubiquitinated substrates.Because deletion of UCH37 is embryonically lethal in mice,this study aims to investigate the role of UCH37 in proteasomal degradation by constructing the UCH37-deficient cell lines using CRISPR/Cas9 technology.Our results demonstrated that deletion of UCH37 decreased the levels of proteasomal Rpn13,implying that UCH37 might facilitate incorporation of Rpn13 into the proteasome.Meanwhile,deletion of UCH37 decreased the levels of β-catenin and the early endosomal protein Rab8.β-Catenin interacts with TCF/LEF to control transcription,and is involved in development,tissue homeostasis and tumorigenesis.We further found that deletion of UCH37 increased the levels of the ubiquitinated β-catenin and accelerated the hydrogen peroxide-stimulated degradation of β-catenin.Deletion of UCH37 also down-regulated the transcription of c-Myc,a downstream effector of β-catenin,and inhibited cell proliferation and motility.These results raise the possibility that UCH37 maintains the homeostasis of proteasomal degradation reciprocally by assisting the recruitment of the ubiquitin receptor Rpn13 into the proteasome and by reversing ubiquitination of certain critical substrates of the 26 S proteasome. | Zijian Li Luming Zhou Tianxia Jiang Libin Fan Xiaoying Liu Xiaobo Qiu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 8 | Nickel catalysts supported on MgO with different specific surface area for carbon dioxide reforming of methane显示文摘In this paper, three kinds of MgO with different specific surface area were prepared, and their effects on the catalytic performance of nickel catalysts for the carbon dioxide reforming of methane were investigated. The results showed that MgO support with the higher specific surface area led to the higher dispersion of the active metal, which resulted in the higher initial activity. On the other hand, the specific surface area of MgO materials might not be the dominant factor for the basicity of support to chemisorb and activate CO2, which was another important factor for the performance of catalysts. Herein, Ni/MgO(CA) catalyst with proper specific surface area and strong ability to activate CO2exhibited stable catalytic property and the carbon species deposited on the Ni/MgO(CA) catalyst after 10 h of reaction at 650 ?C were mainly activated carbon species. | Luming Zhang Lin Li Yuhua Zhang Yanxi Zhao Jinlin Li | 2014 | Journal of Energy Chemistry2014，23，1： | 4 |
| 9 | Deep brain–machine interfaces:sensing and modulating the human deep brain显示文摘Different from conventional brain–machine interfaces that focus more on decoding the cerebral cortex,deep brain–machine interfaces enable interactions between external machines and deep brain structures.They sense and modulate deep brain neural activities,aiming at function restoration,device control and therapeutic improvements.In this article,we provide an overview of multiple deep brain recording and stimulation techniques that can serve as deep brain–machine interfaces.We highlight two widely used interface technologies,namely deep brain stimulation and stereotactic electroencephalography,for technical trends,clinical applications and brain connectivity research.We discuss the potential to develop closed-loop deep brain–machine interfaces and achieve more effective and applicable systems for the treatment of neurological and psychiatric disorders. | Yanan Sui Huiling Yu Chen Zhang Yue Chen Changqing Jiang Luming Li | 2022 | National Science Review2022，9，10： | 3 |
| 10 | Progress in the development of a fully implantable brain–computer interface:the potential of sensing-enabled neurostimulators显示文摘With the advances in neurophysiological recording technology and active implantable medical device development,sensing-enabled neurostimulators have become an emerging technology of the fully implantable brain–computer interface(BCI).These implantable neurostimulators are designed for deep brain stimulation(DBS),a well-established treatment for movement disorders and a promising treatment for psychiatric disorders.By integrating neural recording,sensing-enabled neurostimulators can sample local field potentials(LFPs)through the available contacts of the DBS electrode while delivering stimulation. | Yue Chen Guokun Zhang Linxiao Guan Chen Gong Bozhi Ma Hongwei Hao Luming Li | 2022 | National Science Review2022，9，10： | 3 |
| 11 | Evaluation of Surface Cracks Using Magnetic Flux LeakageTesting显示文摘The magnetic field distribution characteristics of surface cracks with various widths are discussed based on finite element (FEM) results. The crack depth was 0.20 mm, the width range was from 0.02 to 1.00 mm. The results showed that crack width and lift-off (the distance between surface and sensor) will influence signals. Discussed in this paper is the influence of various lift-off parameters on the peak to peak values of the normal component in magnetic flux leakage testing. The effects can be applied to evaluate surface breaking cracks of different widths and depths.An idea is presented to smooth narrow, sharp crack tips using alternating current (AC) field magnetization. | Luming LI, Songling HUANG, Peng ZHENG and Keren SHINUT Center, Mechanical Engineering Department, Tsinghua University, Beijing 100084, China | 2002 | Journal of Materials Science & Technology2002，18，4： | 3 |
| 12 | Spatial and temporal variabilities of rainstorms over China under climate change显示文摘Rainstorms are one of the extreme rainfall events that cause serious disasters,such as urban flooding and mountain torrents.Traditional studies have used rain gauge observations to analyze rainstorm events,but relevant information is usually missing in gauge-sparse areas.Satellite-derived precipitation datasets serve as excellent supplements or substitutes for the gauge observations.By developing a grid-based rainstorm-identification tool,we used the Tropical Rainfall Measurement Mission(TRMM)Multi-satellite Precipitation Analysis(TMPA)time series product to reveal the spatial and temporal variabilities of rainstorms over China during 1998–2017.Significant patterns of both increasing and decreasing rainstorm occurrences were detected,with no spatially uniform trend being observed across the whole country.There was an increase in the area being affected by rainstorms during the 20-year period,with rainstorm centers shifting along the southwest–northeast direction.Rainstorm occurrence was found to be correlated with local total precipitation.By comparing rainstorm occurrence with climate variables such as the El Ni?o-Southern Oscillation and Pacific Decadal Oscillation,we also found that climate change was likely to be the primary reason for rainstorm occurrence in China.This study complements previous studies that used gauge observations by providing a better understanding of the spatiotemporal dynamics of China’s rainstorms. | HUANG Chang ZHANG Shiqiang DONG Linyao WANG Zucheng LI Linyi CUI Luming | 2021 | Journal of Geographical Sciences2021，31，4： | 3 |
| 13 | Ultrahigh rate capability of 1D/2D polyaniline/titanium carbide(MXene)nanohybrid for advanced asymmetric supercapacitors显示文摘High energy density and enhanced rate capability are highly sought-after for supercapacitors in today's mobile world.In this work,polyaniline/titanium carbide(MXene)(PANI/Ti3C2Tx)nanohybrid is synthesized through a facile and cost-effective self-assembly of.one-dimensional(10)PANI nanofibers and two-dimensional(20)Ti3C2Tx nanosheets.PANl!Ti3C2Tx delivers greatly improved specific capacitance,ultrahigh rate capability(67%capacitance retention from 1 to 100 A·g^(-1))as well as good cycle stability.Electrochemical kinetic analysis reveals that PANI/Ti3C2Tx is featured with surface capacitance-dominated process and has a quasi-reversible kinetics at high scan rates,giving rise to an ultrahigh rate capability.By using PANl!Ti3C2Tx as positive electrode,an 1.8 V aqueous asymmetric supercapacitor(ASC)is successfully assembled,showing a maximum energy density of 50.8 Wh·kg^(-1)·(at 0.9 kW-kg-1)and a power density of 18 kW·kg^(-1)(at 26 Wh·kg^(-1)).Moreover,an 3.0 V organic ASC is also elaborately fabricated,·by using PANI/Ti3C2Tx,achieving an ultrahigh energy density of 67.2 Wh·kg^(-1)(at 1.5 kW·kg^(-1))and a power density of 30 kW·kg^(-1)·(at 26.8 Wh·kg^(-1)).The present work not only improves fundamental understanding of the structure-property relationship towards ultrahigh rate capability electrode materials,but also provides valuable guideline for the rational design of high-performance:energy storage devices with both high energy and power densities. | Jinhua Zhou Qi Kang Shuchi Xu Xiaoge Li Cong Liu Lu Ni Ningna Chen Chunliang Lu Xizhang Wang Luming Peng Xuefeng Guo Weiping Ding Wenhua Hou | 2022 | Nano Research2022，15，1： | 2 |
| 14 | Mechanism of micro-wetting of highly hydrophobic coal dust in underground mining and new wetting agent development显示文摘The internal mechanism of the high hydrophobicity of the coal samples from the Pingdingshan mining area was studied through industrial,element,and surface functional group analysis.Laboratory testing and molecular dynamics simulations were employed to study the impact of three types of surfactants on the surface adsorption properties and wettability of highly hydrophobic bituminous coal.The results show that the surface of highly hydrophobic bituminous coal is compact,rich in inorganic minerals,and poorly wettable and that coal molecules are dominated by hydrophobic functional groups of aromatic rings and aliphatic structures.The wetting performance of surfactants as the intermediate carrier to connect coal and water molecules is largely determined by the interaction force between surfactants and coal(Fs-c)and the interaction force between surfactants and water(Fs-w),which effectively improve the wettability of modified coal dust via modifying its surface electrical properties and surface energy.A new type of wetting agent with a dust removal rate of 89%has been developed through discovery of a compound wetting agent solution with optimal wetting and settling performance.This paper provides theoretical and technical support for removing highly hydrophobic bituminous coal dust in underground mining. | Mingzhong Gao Hongmei Li Yun Zhao Yiting Liu Weiqi Zhou Luming Li Jing Xie Jie Deng | 2023 | International Journal of Mining Science and Technology2023，33，1： | 2 |
| 15 | High-performance flexural fatigue of carbon nanotube yarns显示文摘Carbon nanotube yarns(CNTY)possess good specific strength and specific conductivity.As such,their potential for commercial applications is significant.Fatigue performance is a significant consideration in yarn/wire applications.In this study,the flexural fatigue performance of CNTY spun from super-aligned carbon nanotube arrays was investigated using a reversed bending test.The results showed that CNTY exhibited excellent resistance to pure flexural fatigue,significantly outperforming stainless steel wire;CNTY failed where a combination of flexural fatigue and tension–tension fatigue had special hollow fracture morphology,and CNTY resistance remained fundamentally unchanged in the combination fatigue process. | Fu Xu Xiaolong Mo Sen Wan Changqing Jiang Hongwei Hao Luming Li | 2014 | Chinese Science Bulletin2014，59，29： | 2 |
| 16 | Chronically monitoring the deep brain rhythms: from stimulation to recording显示文摘Humans have never stopped exploring their brains,one of the most complex systems in nature.A thorough understanding of the brain is the ultimate challenge for neuroscientists.As there is a rapid increase in the aging populations and the number of brain disorders,researchers are much more eager to clarify how the billions of | Xing Qian Yue Chen Bozhi Ma Hongwei Hao Luming Li | 2016 | Science Bulletin2016，61，19： | 2 |
| 17 | Research on magnetic testing method of stress distribution显示文摘 | LI Luming Huang Songling Wang Laifu | 2002 | Transaction of Nonferrous Metals Society of China2002，12，3： | 1 |
| 18 | Magnetic field abnormality caused by welding residual stress显示文摘 | Li Luming Huang Songling Wang Xiaofeng | 2003 | Journal of Magnetism and Magnetic Materials2003，，261： | 1 |
| 19 | Carbon monoxide augments electrical signaling in cultured neural networks of hippocampal neurons partly through activation of BKCa channels显示文摘 | Hucheng Zhao Bailin Liu Quanyou Zhang Xiao'an WU Yang Yu Forrest Fabian Jesse Luming Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 1 |
| 20 | Ultrasonic generation by exciting electric arc: A tool for grain refinement in welding process 显示文摘 | HE Longbiao LI Luming HAO Hongwei | 2006 | Applied Physics Letters2006，89，13： | 1 |
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