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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | 癫痫为首发症状的儿童甲状旁腺功能减退无需抗癫痫药物治疗显示文摘背景癫痫临床表现具有多样化,从不受控制的抽搐运动(强直-阵挛性发作)到瞬间失去知觉(失神发作)。大脑电脉冲传播到大脑相邻区域并产生不受控制的电活动风暴。癫痫发病机制可分为六类:代谢、结构、遗传、免疫、炎症、特发性。甲状旁腺功能减退是一种由于甲状旁腺激素(Parathyroid hormone,PTH)缺失或任何激素功能抵抗导致的内分泌疾病,表现主要包括低钙血症,高磷血症和异常PTH水平。 | 邹丽萍 Liu MJ Li JW Shi XY | 2017 | 癫痫杂志2017，3，2： | 5 |
| 3 | Effect of polysaccharides of cassiae seeds on the intestinal microflora of piglets显示文摘 | Deng ZY Zhang JW Li J Fan YW Cao SW Huang RL Yin YL Yin, Yu-long Zhong HY Li TJ | 2007 | 中国生物学文摘2007，21，6： | 3 |
| 4 | Parallel algorithm for generalized matrix eigen-problem and its application in calculation of crystal electronic structure显示文摘1 Problem and algorithmMANY computing tasks arising from computational physics, chemistry and biology are relatedto solving so-called generalized eigen-decomposition problems. Consider the following general-ized eigen-decomposition problem: | Sun, JC Deng, JX Cao, JW Wang, DS Zhang, WQ Li, J | 1997 | Chinese Science Bulletin1997，42，13： | 2 |
| 5 | Interleukin-11 (IL-11)in aseptic loosening of total hip replacement(THK)显示文摘 | Xu JW Li TF Partsch G | 1998 | Scand J Rheumatol1998，27，： | 1 |
| 6 | Serum Brain-derived neuro- trophic factor levels in post- stroke depression显示文摘 | Li J Zhao YD Zeng JW | 2014 | J Affect Disord2014，168，： | 1 |
| 7 | Laparoscopic hepatectomy with bile duct exploration for the treatment of hepatolithiasis:an experience of 116 cases显示文摘 | Tian J Li JW Chen J | 2013 | Dig Liver Dis2013，45，6： | 1 |
| 8 | Late Paleoproterozoic to early Mesoproterozoic Dong Chuan Group in Yunnan, SW China:Implications for tectonic evolution of t he Yangtze Block 显示文摘 | Zhao XF Zhou MF Li JW | 2010 | Precambrian Research2010，182，3： | 1 |
| 9 | The prevalence of primary glaucoma in mainland China : a system- atic review and meta-analysis显示文摘 | CHENG JW CHENG SWjMA XY CAI JP LI Y WEI RL | 2013 | J Glaucoma2013，22，4： | 1 |
| 10 | Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions a high-resolution MR imaging study显示文摘 | Xu WH Li ML Niu JW | 2014 | J Neurol Sci2014，339，： | 1 |
| 11 | Mechanisms of inactivation of Hepatitis A Virus by chlorine 显示文摘 | Li JW Zhong TX Wang XW | 2002 | Applied and Environmental Microbiology2002，68，10： | 1 |
| 12 | Vascularity in asthmatic airways: relation to inhaled steroid dose 显示文摘 | Orsida BE Li X Hickey B Thien F Wilson JW Waiters EH | 1999 | Thorax1999，54，4： | 1 |
| 13 | Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension显示文摘 | Cao Y Li H Mu FT Ebisui O Funder JW Liu JP | 2002 | FASEB2002，16，1： | 1 |
| 14 | Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes显示文摘 | Bai XY Li X Tian JW' | 2014 | PLoS One2014，9，96： | 1 |
| 15 | Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction显示文摘 | Fung JW Li TS Choy DK | 2002 | Chest2002，121，2： | 1 |
| 16 | Luminal thrombosis in middle cerebral artery occlusions: a high-resolution MRI study显示文摘 | Xu WH Li ML Niu JW | 2014 | Ann Transl Med2014，2，： | 1 |
| 17 | The clinical applications of multifocal electroretinography: a systematic re- view 显示文摘 | Lai TY Chan WM Lai RY Ngai JW Li H Lmn DS | 2007 | Surv Ophthalmol2007，52，1： | 1 |
| 18 | Stability of black tea polyphenol, theaflavin, and identifyication of theanaphthoquinone as its major radical reaction product显示文摘 | JHoo JW Lo CY Li SM | 2005 | J Agri Food Chem2005，53，： | 1 |
| 19 | Binding pancreaticojejunostomy-a safe and reliable anastomosis procedure显示文摘 | Peng SY Wang JW Li JT | 2004 | HPB2004，6，： | 1 |
| 20 | Laparoscopic hepatectomy with bile duct exploration for the treatment of hepatolithiasis:an experience of 116 cases显示文摘 | Tian J Li JW Chen J | | 0，，06： | 1 |
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