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| 1 | A study of storage and distribution of double fortified salts in Kenya 显示文摘 | Levente Diosady Rizwan Yusufalil Toks Oshinowo | 2006 | Journal of Food Engineering2006，76，4： | 1 |
| 2 | Epidemiological characteristics and visual outcome after open globe injuries in children显示文摘 | Ozlem Tok Levent Tok Dilek Ozkaya Elif Eraslan Firdevs Ornek Yavuz Bardak | 2011 | Journal of AAPOS2011，，6： | 1 |
| 3 | Effects of astaxanthin on antioxidant parameters in ARPE-19 cells on oxidative stress model显示文摘AIM: To observe the protective effect of astaxanthin(AST) against hydroquinone(HQ) mediated cell death in the apoptotic cascade and evaluate intracellular Ca2+ release, caspase-3, and-9 activation, reactive oxygen species(ROS) production in ARPE-19 cells.METHODS: We cultured ARPE-19 cells in special mediums and performed MTT tests to determine protective effect of AST, before exposing the cells to HQ in an incubator. We analyzed intracellular Ca2+ release experiments, mitochondrial membrane depolarization, glutathione(GSH), glutathione peroxidase(GSH-Px) and ROS experiments, and apoptosis assay.RESULTS: ROS production ranges depend on the amount of cell death. We computed the correlation between ROS ranges and cell death by 20,70-dichlorofluorescein fluorescence, and Ca2+ levels by Fura-2-AM. HQ-induced cell death found out to rise ranges of caspase-3 and-9, and mitochondrial depolarization. These three steps were delayed by AST management.CONCLUSION: ARPE-19 cells are avoided from HQinduced ROS production and caspase-3 and-9 activation by AST. AST may limit the range of caspase synthesis, Ca2+ release and excess production of ROS with antiapoptotic effect. This study proposes a new therapeutic approach for the treatment of age-related macular degeneration. | Yigit Musa Günes Alime Uguz Cihangir Yalcin Tok Ozlem Tok Levent Oz Ahmi Naziroglu Mustafa | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 1 |
| 4 | Epidemiological characteristics and visual outcome after open globe injuries in children显示文摘 | Ozlem Tok Levent Tok Dilek Ozkaya Elif Eraslan Firdevs Ornek Yavuz Bardak | 2011 | Journal of AAPOS2011，，6： | 1 |
| 5 | Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment显示文摘AIM: To evaluate the clinical findings of toxic keratopathy associated with abuse of topical anesthetics and the treatment efficacy of amniotic membrane transplantation(AMT).·METHODS: Fifteen eyes of 10 patients with abuse of topical anesthetics were included in this study. The data collected included patients' demographic information,initial best corrected visual acuity(BCVA), clinical findings, time to AMT, duration of epithelization,additional treatments, posttreatment BCVA, and the results of psychiatric examination.·RESULTS: All patients were male, with the mean age of37.9 ±5.4y. The patients had received 0.5% proparacaine hydrochloride due to pain resulting from foreign bodies,such as welding flash burns and car battery explosions,for a mean of 18.2 ±12.4d. The mean initial BCVA of the patients was 0.069 ±0.100. All patients had persistent epithelial defects, stromal infiltration, ring ulcer, and corneal edema. Initially, medical treatment was attempted in all cases. Because of severe pain, persistent epithelial defects and progressing stromal thinning did not improve with medical treatment, thus, the patients underwent AMT. The mean posttreatment BCVA of the patients was 0.33 ±0.27. All of them, except for two patients, showed improved visual acuity. One patient underwent evisceration for corneal melting and endophthalmitis in another center, and one patient underwent evisceration for severe pain of unknown origin. All 5 patients who consented to a psychiatric examination had depression, had personality disorder,and used tobacco.·CONCLUSION: AMT appears to be an effective method for pain relief, rapid epithelial and stromal healing;however, visual prognosis is still poor despite medical and surgical interventions. | Ozlem Yalcin Tok Levent Tok Inci Meltem Atay Tugba Cakmak Argun Nazire Demirci Alime Gunes | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 0 |
| 6 | Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep显示文摘AIM: To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS: This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay(ELISA) kit. The limit of determination was 0.9 ng/m L for bevacizumab and 0.62 ng/m L for ranibizumab.RESULTS: At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA kit.CONCLUSION: This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period. | Tugba Cakmak Argun Ozlem Yalcin Tok Levent Tok Gulsen Yilmaz Fatma Meric Yilmaz Alime Gunes Mehmet Argun Osman Butuner | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 0 |
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