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64篇 您的检索式：作者名="Leong PL"

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	题名	作者	年代	出处	被引量
1	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.	Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey	2011	World Journal of Gastroenterology2011，17，8：	13
2	Targeted inhibition of STAT3 with a decoy oligonucleot ide abrogates head and neck cancer cell growth 显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
3	Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
4	Differntial function of STAT5 isoforms in head and neck cancer growth control显示文摘	Leong PL Xi S Drenning SD	2002	Oncogene2002，21，18：	1
5	In vitro differentiation study onisolated human mesenchymal stem cells显示文摘	Mok PL Cheong SK Leong CF	2008	Malays J Pathol2008，301，：	1
6	Skeletonized inter-nal thoracic artery harvesting reduces chest wall dysesthesia after coronary bypass surgery显示文摘	Markman PL Rowland MA Leong JY	2010	J Thorac Cardiovasc Surg2010，139，3：	1
7	Differential function of STAT5 isoforms in head and neck cancer growth control显示文摘	Leong PL Xi SC Drenning SD	2002	Oncogene2002，21，18：	1
8	Targeted inhibition of STAT3 with a decoy oligonusleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GS Johnson DE	2003	Pro Natl Acad Sci USA2003，100，7：	1
9	Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
10	Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
11	Target- ed-inhibition of STAT3 with adecoyoligo nucleotide abrogates head and neck cancer cell growth 显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
12	Targeted inhi- bition of Star3 with a decoy oligonucleotide abrogates head and neck cancer cell growth 显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
13	Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Nat Acad Sci USA2003，100，7：	1
14	Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
15	Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1
16	Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates herd and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad SciUSA2003，100，7：	1
17	Ultrasonography of intra-abdominal cystic lesions in the newborn显示文摘	Khong PL Cheung SC Leong LL	2003	Clin Radiol2003，58，6：	1
18	Diffemtial function of STAT5 isoforms in head and neck cancer growth control显示文摘	Leong PL Xi S Drenning SD	2002	Oncogene2002，21，18：	1
19	Targeted inhibition of STAT3 with a decoy o1igonuc1eotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Nat1 Acad Sci USA2003，100，7：	1
20	Targeted inhi- bition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong PL Andrews GA Johnson DE	2003	Proc Natl Acad Sci USA2003，100，7：	1

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