|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal Transplantation, Through Colonoscopy, Is Effective Therapy for Recurrent Clostridium difficile Infection显示文摘 | Eero Mattila Raija Uusitalo–Sepp?l? Maarit Wuorela Laura Lehtola Heimo Nurmi Matti Ristikankare Veikko Moilanen Kimmo Salminen Maaria Sepp?l? Petri S. Mattila Veli–Jukka Anttila Perttu Arkkila | 2012 | Gastroenterology2012，，3： | 3 |
| 2 | Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment显示文摘AIM: Lymphocytic gastritis is commonly ass ociated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation,forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis,and to evaluate the effect of H pylori treatment.METHODS: We studied 14 lymphocytic gastritis patients with H pylori infection. For controls, we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been eradicated.Both groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls). Blinded evaluation for histopathological features was carried out. To determine the cell proliferation index,the sections were labeled with Ki-67 antibody.RESULTS: Before treatment, lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008), and increased proliferation in both the body (P=0.001) and antrum (P=0.002). Proliferation correlated with foveolar hyperplasia and inflammation activity. After eradication therapy, the number of intraepithelial lymphocytes decreased in the body (P=0.004)and antrum (P=0.065), remaining higher than in controls (P<0.001). Simultaneously, the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043), and in the antrum from 0.34 to 0.20 (P=0.069), the antral index still being higher in lymphocytic gastritis than in controls (P=0.010).Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021), reaching the non-LG level.CONCLUSION: In lymphocytic gastritis, excessive epithelial cell proliferation is predominantly present in the body, where it associates with foveolar hyperplasia and glandular atrophy.These characteristic changes of lymphocytic gastritis are largely related to H pylori infection, as shown by their improvement after eradication. However, some residual deviation was still seen in lymphocytic gastritis, indicating either an abnormally slow improvement or the presence of some persistent abnormality. | Johanna M.Mkinen Seppo Niemel Tuomo Kerola Juhani Lehtola Tuomo J.Karttunen | 2003 | World Journal of Gastroenterology2003，9，12： | 2 |
| 3 | Changes in content of microbially available phosphorus,assimilable organic carbon and microbi al growth potential during drinking water treatment processes显示文摘 | Lehtola M J Miettinen I T Vartiainen T | 2012 | Water Research2012，41，： | 1 |
| 4 | A new sensitive bioassay for determination of microbially available phosphorus in water显示文摘 | Lehtola M J Miettinen I T Vartiainen T | 2011 | Ap pl Environ Microbiol2011，65，5： | 1 |
| 5 | Effects of Noise and Filtering on SVD - Based Morphological Pa- rameters of the T Wave in the ECG 显示文摘 | Lehtola L Karsikas M Koskinen M | 2008 | Journal of Medical Engineering and Technology2008，32，5： | 1 |
| 6 | A new sensitive bioassay for determination of microbially available phosphorus in water显示文摘 | Lehtola M J Miettinen I T Vartiainen T | 1999 | Applied and Environmental Microbiology1999，65，5： | 1 |
| 7 | Deep venous reconstructions : long-term outcome in patients with primary or post-thrombotic deep venous incompetence 显示文摘 | Lehtola A Oinonen A Sugano N | 2008 | Eur J Vasc Endovasc Surg2008，35，4： | 1 |
| 8 | Microbiology,chemistry and biofilm development in a pilot drinking water distribution system with copper and plastic pipes显示文摘 | Lehtola MJ Miettinen IT Kein?nen MM | | 0，，17： | 1 |
| 9 | Rapid enumeration of virus-like particles in drinking water samples using SYBR green I-staining显示文摘 | Rinta-Kanto JM Lehtola MJ Vartiainen T | 2004 | Water Res2004，38，： | 1 |
| 10 | Bio- film formation in drinking water affected by low concentrations of phosphorus显示文摘 | Lehtola M J Miettinen I T Myllykangas T | 2002 | Canadian Journal of Microbiology2002，48，6： | 1 |
| 11 | Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism:a novel example of epigenetherapy显示文摘 | Turunen M P Lehtola T Heinonen S E | 2009 | Circ Res2009，105，6： | 1 |
| 12 | Changes in content of microbially available phosphorus, assimilable organic carbon and mi- crobial growth potential during drinking water treatment processes 显示文摘 | Lehtola M J Miettinen I T Vartiainen T | 2002 | Water Research2002，36，15： | 1 |
| 13 | Microbiology chemistry and biofilm development in a pilot drinking water distribution system with copper and plastic pipes显示文摘 | Lehtola M J Miettinen I T Keinanen M M | 2004 | Water Res2004，38，17： | 1 |
| 14 | Biofilm formation in drinking water affected by low concentrations of phosphorus显示文摘 | Lehtola M J Miettinen I T Martikainen P J | 2002 | Canadian journal of microbiology2002，48，6： | 1 |
| 15 | Gastric cancer:Surgical management and prognosis显示文摘 | Arak A Lehtola J Makela J | | 0，，： | 1 |
| 16 | The microbial community structure of drinking water biofilms can be affected by phosphorus availability显示文摘 | Keinanen M M Korhonen L K Lehtola M J | 2002 | Applied and environmental microbiology2002，68，1： | 1 |
| 17 | Microbiology,chemistry and biofilm development in a pilot drinking water distribution system with copper and plastic pipes显示文摘 | Markku J Lehtola | 2004 | Water Research2004，38，17： | 1 |
| 18 | Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy显示文摘 | Turunen MP Lehtola T Heinonen SE | 2009 | Circ Res2009，105，： | 1 |
| 19 | Human leucocyte antigen and TNFα polymorphism association in microscopic colitis显示文摘 | Ritva M. Koskela Tuomo J. Karttunen Seppo E. Niemel? Juhani K. Lehtola Jorma Ilonen Riitta A. Karttunen | 2008 | European Journal of Gastroenterology & Hepatology2008，，4： | 1 |
| 20 | A new sensitive biosssay for determination of microbially available phosphorus in water显示文摘 | Ilkka T Miettinen Terttu Vartiainen | 1999 | Appl Environ Microbiol1999，65，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员