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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Perspectives damelioration genetique des peupliers en France显示文摘 | Villar M Lefevre F Augustin S | 1995 | Comptes Rendus de I′Academie d′Agriculture de France1995，81，3： | 2 |
| 3 | The rodent uterotrophic assay critical protocol features, Studies with nonyl phenols, and comparison with a Yeast Estrogenicity Assay 显示文摘 | Odum J Lefevre P A Tittensor S | 1997 | Regulatory Toxicology and Pharmacology1997，25，： | 1 |
| 4 | Secretome of pri mary cultures of human adipose-derived stem cells:modulation of serpins by adipogenesis显示文摘 | Zvonic S Lefevre M Kilroy G | 2007 | Mol Cell Proteomics2007，6，1： | 1 |
| 5 | Stochastic orderings of convex/concave type on an arbitrary grid显示文摘 | DENU1T M LEFEVRE C L UTEV S | 1999 | Mathematics of Operations Research1999，24，4： | 1 |
| 6 | Classical swine fever: the global situation显示文摘 | Edwards S Sukusho A Lefevre P C | 2000 | Vet M icrobiol2000，73，23： | 1 |
| 7 | Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype显示文摘 | Lefevre G M Patel S R Kim D | 2010 | PLoS Genet2010，6，10： | 1 |
| 8 | On lexicographical ordering in multivariate mathematical morphology显示文摘 | APTOULA E LEFEVRE S | 2008 | Pattern Recognition Letters2008，29，2： | 1 |
| 9 | Clinical significance of micrometastases detection in lymph nodes from head and neck squamous cell carcinoma显示文摘 | XU Y LEFEVRE M PERIE S | 2008 | Otolaryngol Head Neck Surg2008，139，3： | 1 |
| 10 | Classical swine fever: the global situation 显示文摘 | Edwards S Fukusho A Lefevre P C | 2000 | Vet Microbiol2000，73，23： | 1 |
| 11 | Feasibility of laparoscopic restorative proctocolectomy without diverting stoma 显示文摘 | Hor T Zalinski S Lefevre JH | 2012 | Dig Liver Dis2012，44，2： | 1 |
| 12 | Synovial fibro- blasts spread rheumatoid arthritis to unaffected joints 显示文摘 | Lefevre S Knedla A Tennie C | 2009 | Nat Med2009，15，12： | 1 |
| 13 | Discrimination between the ionic and osmotic components of salt stress in relation to free polyamine level in rice(Oryza sativa)显示文摘 | Lefevre I Gratia E Lutts S | 2001 | Plant Sci2001，161，5： | 1 |
| 14 | Classical swine fever: the global situation 显示文摘 | EDWARDS S FUKUSHO A LEFEVRE P C | 2000 | Vet Microbiol2000，73，23： | 1 |
| 15 | Classical swine fever: the global situation 显示文摘 | Edwards S Fukusho A Lefevre P C | 2000 | Vet Microbial2000，73，23： | 1 |
| 16 | Morphological description of color images for content-based image retrieval 显示文摘 | APTOULA E LEFEVRE S | 2009 | IEEE Transactions on Image Processing2009，18，11： | 1 |
| 17 | Tetracycline-controlled expression of glycosylated porcinein terferon gamma in mammalian cells显示文摘 | Lefevre A Cencic S Koren | 1999 | Animal Biotechnolog1999，10，12： | 1 |
| 18 | Support Vector Machine (SVM) based multiclaass prediction with basic statistical a- nalysis of plasminogen activators 显示文摘 | MUTHUKRISHNAN S PURl M LEFEVRE C | 2014 | BMC Research Notes2014，7，63： | 1 |
| 19 | Analytical performance of ACB test for ischemia on the konelab 20显示文摘 | Lefevre G Graine H Rouy S | 2003 | Clin Chem2003，49，： | 1 |
| 20 | Combined effects of thefilling ratio and the vapour space thickness on theperformance of a flat plate heat pipe显示文摘 | Lips S Lefevre F Bonjour J | 2010 | InternationalJournal of Heat Mass Transfer2010，53，4： | 1 |
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