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3篇 您的检索式：作者名="Leca Nicolae"

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		题名	作者	年代	出处	被引量
	1	Leflunomide use in renal transplantation 显示文摘	Leca Nicolae	2009	Current Opinion in Organ Transplantation2009，14，4：	1
	2	Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report显示文摘BACKGROUND The liver has traditionally been regarded as resistant to antibody-mediated rejection(AMR).AMR in liver transplants is a field in its infancy compared to kidney and lung transplants.In our case we present a patient with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant complicated by acute liver failure(ALF)with evidence of antibody mediated rejection on allograft biopsy and elevated serum donor-specific antibodies(DSA).This case highlights the need for further investigations and heightened awareness for timely diagnosis.CASE SUMMARY A 56 year-old woman with alpha-1-antitrypsin disease underwent ABO compatible liver transplant from a deceased donor.The recipient MELD at the time of transplant was 28.The flow cytometric crossmatches were noted to be positive for T and B lymphocytes.The patient had an uneventful recovery postoperatively.Starting on postoperative day 5 the patient developed fevers,elevated liver function tests,distributive shock,renal failure,and hepatic encephalopathy.She went into ALF with evidence of antibody mediated rejection with portal inflammation,bile duct injury,endothelitis,and extensive centrizonal necrosis,and C4d staining on allograft biopsy and elevated DSA.Despite various interventions including plasmapheresis and immunomodulating therapy,she continued to deteriorate.She was relisted and successfully underwent liver retransplantation.CONCLUSION This very rare case highlights AMR as the cause of ALF following liver transplant requiring retransplantation.	Todd J Robinson James B Hendele Idoia Gimferrer Nicolae Leca Scott W Biggins Jorge D Reyes Lena Sibulesky	2022	World Journal of Hepatology2022，14，1：	0
	3	Is MELD score failing patients with liver disease and hepatorenal syndrome?显示文摘There is a need to reassess the application of MELD and the impact of renal insufficiency with consideration for developing an algorithm with exception points that would lead to timely allocation of livers to patients with hepatorenal syndrome prior to occurrence of permanent renal damage without jeopardizing post-transplant survival.	Lena Sibulesky Nicolae Leca Christopher Blosser Amir A Rahnemai-Azar Renuka Bhattacharya Jorge Reyes	2016	World Journal of Hepatology2016，8，27：	0

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