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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Assessment of acute pain and anxiety in children and adolescents by self - reports, observer reports, and a behavior checklist 显示文摘 | LeBaron S Zeltzer L | 1954 | J Consult Clin Psychol1954，52，5： | 1 |
| 3 | Homostructured mixed inorganic-organic ion clays:a new approach to epoxy polymer-exfoliated clay nanocomposites with a reduced organic modifier content显示文摘 | Costas S Triantafillidis Peter C LeBaron Thomas J Pinnavaia | 2002 | Chem Mater2002，14，： | 1 |
| 4 | Use of traditional medi-cine in Mongolia: a suvey 显示文摘 | Bernstein J A Stibich M A LeBaron S | 2002 | Complement Ther Med2002，10，1： | 1 |
| 5 | Epoxy-clay fabric film composites with unprecedented oxygen-barrier properties 显示文摘 | Triantafyllidis K S LeBaron P C Park I | 2006 | Chemistry of Materials2006，18，18： | 1 |
| 6 | Homostructured mixed inorganic-organic ion clays : a new approach to epoxy polymer-exfoliated clay nanocomposites with a reduced organic modifier content显示文摘 | Triantafillidis C S LeBaron P C Pinnavaia T J | 2002 | Chem Mater(S0897-4756)2002，14，10： | 1 |
| 7 | Up-regulation of stromal versican expression in advanced stage serous ovarian cancer显示文摘 | Ghosh S Albitar L LeBaron R | 2010 | Gyneeol Oncol2010，119，1： | 1 |
| 8 | homostructured mixed inorganic-organic ion clays: a new approach to epoxy polymer-exfoliated clay nanocomposites with a reduced organic modifier content显示文摘 | Triantafillidis C S LeBaron P C Pinnavaia T J | 2002 | Chem Mater2002，14，： | 1 |
| 9 | Persistence of measles antibodies after 2 doses of measles vaccine in a postelimination environment显示文摘 | LeBaron CW Beeler J Sullivan BJ Forghani B Bi D Beck C Audet S Gargiullo P | 2007 | Arch Pediatr Adolesc Med2007，161，3： | 1 |
| 10 | Up-regulation of stromal versican expression in advanced stage serous ovarian cancer 显示文摘 | Ghosh S Albitar L LeBaron R | 2010 | Gynecol Oncol2010，119，1： | 1 |
| 11 | Global seasonality of rotavirus infections 显示文摘 | COOK S M GLASS R I LEBARON C W | 1990 | Bull World Health Organ1990，68，2： | 1 |
| 12 | An investigation of cold pressor pain in ehildre显示文摘 | geltzer L K Fanurik D | 1989 | Pain1989，37，： | 1 |
| 13 | The cold pressor pain paradigm in ehildren:Feasibility of an intervention model显示文摘 | Fanurik D Lebaron S | 1989 | Pain1989，37，： | 1 |
| 14 | Thermoset epoxy-clay nanocomposites: The dual role of diamines as clay surface modifiers and polymer curing agents 显示文摘 | Triantallidis C S LeBaron P C Pinnavaia T J | 2002 | Journal of Solid State Chemistry2002，167，： | 1 |
| 15 | Global seasonality of rotavirus infections显示文摘 | COOK S M GLASS R I LEBARON C W | 1990 | Bull WHO1990，68，2： | 1 |
| 16 | Homostruc- tured mixed inorganic-organic ion clays: A new approach to ep- oxy polymer-exfoliated clay nanocomposites with a reduced or- ganic modifier content 显示文摘 | Triantafillidis C S LeBaron P C Pinnavaia T J | 2002 | Chemistry of Materials2002，14，10： | 1 |
| 17 | The spli- cing ATPase Prp43p is a component of multiple preribo- somal particles显示文摘 | Lebaron S Froment C Fromont-Racine M | 2005 | Mol Cell Biol2005，25，： | 1 |
| 18 | Thermoset epoxy-clay nanocomposites: the dual role of -diamines as clay surface modifiers and polymer curing agents显示文摘 | Triantafillidis C S LeBaron P C Pinnavaia T J | 2002 | J Solid State Chemistry2002，167，： | 1 |
| 19 | A Randomized,Controlled Study of Behavioral Intervention for Chemotherapy Distress in Children with Cancer显示文摘 | Zeltzer L K Dolgin M J LeBaron S | 1991 | Pediatrics1991，88，1： | 1 |
| 20 | Global seasonalitv of rotavirus infections 显示文摘 | Cook S M Glass R I LeBaron C W | 1990 | Bull WHO1990，68，2： | 1 |
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