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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 3 | Human herpervirus-6 clinical implications of a recently discovered ubiquitous agent显示文摘 | Charles T Leach MD Ciro V | 1992 | J Pediatr1992，121，2： | 2 |
| 4 | The Kelian disseminated gold deposit,East Kalimantan,Indonesia显示文摘 | Van Leeuwen T M Leach T Hawke A A | 1990 | Journal of Geochemical Exploration1990，50，： | 1 |
| 5 | Rates of infection and revision in patients with renal disease undergoing total knee replacement in Scotland显示文摘 | Mc Cleery MA Leach WJ Norwood T | 2010 | J Bone Joint Surg Br2010，92，11： | 1 |
| 6 | Structure of the starch granule Ⅱ action of various amylases on granular 显示文摘 | Leach H W Schoch T J | 1961 | Starch Cereal Chem1961，，38： | 1 |
| 7 | Angiontensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload 显示文摘 | Folland Leach B Little T | 2000 | Exp Physiol2000，85，5： | 1 |
| 8 | Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload显示文摘 | Folland J Leach B Little T | 2000 | Exp Physiol2000，85，5： | 1 |
| 9 | Probe-compensated near-field measurements on a cylinder 显示文摘 | Leach W M Paris D T | 1973 | IEEE Transactions on Antennas Propagation1973，21，4： | 1 |
| 10 | Mississippi valley-type lead-zinc deposits through geological time: implications from recent age-dating research显示文摘 | Leach D L Bradley D Lewchuk M T | 2001 | Mineralium Deposita2001，36，： | 1 |
| 11 | Molecular and virologic characteristics of lymphoid malignancies in children with AIDS显示文摘 | McClure K L Leach C T Jenson H B | 2000 | J Acquir Immune Defic Syndr2000，23，： | 1 |
| 12 | Guilt, an- ger, and pride about in-group environmental behav- iour: Different emotions predict distinct intentions 显示文摘 | HARTH N S LEACH C W KESSLER T | 2013 | Journal of Environmental Psychology2013，34，： | 1 |
| 13 | Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts 显示文摘 | Jaken S Leach K Klauck T | 1989 | J Cell Biol1989，109，2： | 1 |
| 14 | 显示文摘 | Shin K Leach K A Goldbach J T | 2002 | Nano Lett2002，2，： | 1 |
| 15 | Effect of structural conduction and heat loss on combustion in micro-channels显示文摘 | Leach T T Cadou C P Jackson G S | 2006 | Combustion Theory andModeling2006，10，1： | 1 |
| 16 | Measurements of human breast cancer using magnetic resonance spectroscopy:a review of clinical measurements and a report of localized ^31p measurements of response to treatment显示文摘 | Leach M O Verrill M Glahoim J Smith T A Coliins D J Payne G S | 1998 | NMR Biomed1998，11，： | 1 |
| 17 | Role of in ternalization of Mz muscarinic receptor via clathrin-eoated ves ides in desensitization of the muscarinic K: current in heart 显示文摘 | YAMANUSH1 T T SHUI Z LEACH R N | 2007 | Am J Phys Heart Circ Phys2007，292，17： | 1 |
| 18 | Effect of structural heat conduction and heat loss on combustion in micro-channels显示文摘 | Leach T Cadou C P Jackson G | 2005 | Combustion Theory and Modeling2005，10，1： | 1 |
| 19 | The effect of empowerment on job knowledge: an empirical test involving operators of complex technology显示文摘 | Leach D J Wall T D and Jackson P R | 2003 | Journal of Occupational and Organizational Psychology2003，76，1： | 1 |
| 20 | The role of structural heat exchange and heat loss in the design of efficient silicon micro-combustors显示文摘 | Leach T T Cadou C P | 2004 | Proceedings of the Combustion Institute2004，30，2： | 1 |
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