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您的检索式：作者名="Lawrence C.M"
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| 1 | 最小范围皮肤切除的选择性汗腺切除术治疗腋汗症:15例患者的临床与组织学回顾性分析显示文摘Background: Limited axillary skin excision and selective sweat gland removal from adjacent skin (Shelley’ s procedure) is currently rarely used for hyperhidrosis. Objectives: To determine whether this technique is a good way of permanently reducing axillary sweating. Methods: This was a prospective, open, nonrandomized trial of the therapy, conducted in a university dermatology department. A small skin ellipse, parallel to the skin crease lines, was excised from the centre of the area of maximal sweating. The wound edges were undermined to the extent of maximal sweating and the skin reflected. Large visible sweat glands attached to the undersurface of the adjacent skin could be readily identified and were snipped off using scissors. We treated 15 axillae in eight patients with axillary hyperhidrosis. Sweat reduction was assessed by the patients who estimated the percentage reduction in sweating postoperatively. The scar appearance was graded by the surgeon. Haematoxylin and eosin-stained transverse sections of eight axillary skin ellipses from five subjects were examined histologically to establish the size, position and depth of the sweat gland tissue. Results: All of the patients responded to treatment: mean sweat reduction was 65% (range 40- 90% ). Mean follow up was 1.3 years (range 0.1- 6) and sweat reduction was maintained over this period. Histological material was available from five patients: sweat glands lay slightly deeper than hair follicles; glandular tissue occupied an average thickness of 3.5 mm in the 5- mm thick piece of skin. Apocrine gland lobules were more numerous and larger than eccrine gland lobules. Both gland types were in close apposition and did not occupy distinctly different depths within the skin. Conclusions: Local surgery using limited axillary skin excision and selective sweat gland removal remains one of the safest ways of permanently reducing axillary sweating. | Lawrence C.M Lonsdale Eccles A.A. 朱国兴 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 2 |
| 2 | 皮肤恶性肿瘤的治疗:我们应依赖临床诊断至何种程度?显示文摘Background: Cutaneous malignancy forms a major part of the dermatologist’ s workload. Clinical diagnosis is an important factor in facilitating the urgent excision of squamous cell carcinomas (SCC) and malignant melanomas. Objectives: To identify the numbers and types of malignant skin tumours managed in an NHS teaching hospital and to assess the diagnostic accuracy. Methods: Data were collected on every histologically proven malignant skin lesion over a 6-month period. Results: One thousand one hundred and ninety-five malignant skin tumours were identified: 78% were basal cell carcinomas, 14% were SCC, 6% were malignant melanomas and the remaining 2% included Merkel cell tumours, malignant adnexal tumours and lentigo maligna. Eighty-one per cent of the tumours were managed by dermatologists. The correct clinical diagnosis had been made by the secondary care clinician in 84% of cases but an incorrect clinical diagnosis was given in 32% of SCC. Of the 1195 tumours, 916 (77% ) had a primary excision and 92% (843 of 916) of these were completely excised. Conclusions: The majority of skin malignancies (968 of 1195, 81% ) were managed by dermatologists. Where primary excision was attempted, this was complete in 91% (767 of 916) of cases. The correct clinical diagnosis was made in 84% of all tumours, but 32% of SCC were not correctly diagnosed prior to surgery. | Brown S.J Lawrence C.M 李政霄 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 0 |
| 3 | 肝移植后皮肤钙化 | Lateo S Charlton F Hudson M Lawrence C.M 冯义国 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，10： | 0 |
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