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| 1 | 芽胞杆菌益生菌在水产业的应用显示文摘芽孢杆菌被认为兼有改善水生动物消化道和改良水环境的双重功效而受重视。文中阐述了益生菌在水产养殖中应用的最新理论、技术和趋势,包括运用分子生物学方法进行菌株的分型鉴定和安全性检测,对病原菌和病原性病毒的拮抗试验,以及一系列的大田养殖试验,以验证芽胞杆菌益生菌产品在水产上尤其是在大型养虾场应用的功效。 | 吴希阳 Kevin Healey Chris Lawlor James Chin 赵晖 | 2007 | 渔业现代化2007，34，4： | 6 |
| 2 | Greenhouse gas emissions from different pig manure management techniques: a critical analysis显示文摘 | Conor Dennehy Peadar G. Lawlor Yan Jiang Gillian E. Gardiner Sihuang Xie Long D Nghiem Xinmin Zhan | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 5 |
| 3 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 4 | Use of methotrexate in inflammatory bowel disease in 2014: A User's Guide显示文摘Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients. | Arun Swaminath Raja Taunk Garrett Lawlor | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 4 |
| 5 | Ampulla of Vater carcinoma: Molecular landscape and clinical implications显示文摘Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well. | Antonio Pea Giulio Riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 4 |
| 6 | Harnessing the HDAC–histone deacetylase enzymes,inhibitors and how these can be utilised in tissue engineering显示文摘There are large knowledge gaps regarding how to control stem cells growth and differentiation.The limitations of currently available technologies,such as growth factors and/or gene therapies has led to the search of alternatives.We explore here how a cell’s epigenome influences determination of cell type,and potential applications in tissue engineering.A prevalent epigenetic modification is the acetylation of DNA core histone proteins.Acetylation levels heavily influence gene transcription.Histone deacetylase (HDAC) enzymes can remove these acetyl groups,leading to the formation of a condensed and more transcriptionally silenced chromatin.Histone deacetylase inhibitors (HDACis) can inhibit these enzymes,resulting in the increased acetylation of histones,thereby affecting gene expression.There is strong evidence to suggest that HDACis can be utilised in stem cell therapies and tissue engineering,potentially providing novel tools to control stem cell fate.This review introduces the structure/function of HDAC enzymes and their links to different tissue types (specifically bone,cardiac,neural tissues),including the history,current status and future perspectives of using HDACis for stem cell research and tissue engineering,with particular attention paid to how different HDAC isoforms may be integral to this field. | Liam Lawlor Xuebin B. Yang | 2019 | International Journal of Oral Science2019，11，2： | 3 |
| 7 | Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective显示文摘The use of thiopurines in inflammatory bowel disease(IBD) has been examined in numerous prospective, controlled trials, with a majority demonstrating a clinical benefit. We conducted this review to describe the historical and current evidence in the use of thiopurines in IBD. A systematic search was performed on MEDLINE between 1965 and 2016 to identify studies on thiopurines in IBD. The most robust evidence for thiopurines in IBD includes induction of remission in combination with anti-tumor necrosis factor(antiTNF) agents, and maintenance of remission and postoperative maintenance in Crohn's disease. Less evidence exists for thiopurine monotherapy in induction of remission, maintenance of ulcerative colitis, chemoprevention of colorectal cancer, and in preventing immunogenicity to anti-TNF. Evidence was often limited by trial design. Overall, thiopurines have demonstrated efficacy in a broad range of presentations of IBD. With more efficacious novel therapeutic agents, the positioning of thiopurines in the management of IBD will change and future studies will analyze the benefit of thiopurines alone and in conjunction with these new medications. | Jordan E Axelrad Abhik Roy Garrett Lawlor Burton Korelitz Simon Lichtiger | 2016 | World Journal of Gastroenterology2016，22，46： | 3 |
| 8 | Process stability and microbial community composition in pig manure and food waste anaerobic co-digesters operated at low HRTs显示文摘这研究估计了猪粪肥和食物浪费的从 21 天把水力的保留时间(HRT ) 归结为厌氧地共同消化的 10.5 天的效果。3.75 L 的连续地搅动的坦克反应堆工作体积被操作在在 42 瑮 ? 湡 ? 潭畤楬眠牥 ?潣灭瑵摥愠摮愠慮祬敺 d | Conor Dennehy Peadar G. Lawlor Gillian E. Gardiner Yan Jiang Paul Cormican Matthew S. McCabe Xinmin Zhan | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 2 |
| 9 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 10 | Childhood obesity显示文摘 | Joan C Han Debbie A Lawlor Sue YS Kimm | 2010 | The Lancet2010，，9727： | 2 |
| 11 | Neuronal death and survival in two models of hypoxic-ischemic brain damage 显示文摘 | Walton M Connor B Lawlor P | 1999 | Brain Res Rev1999，29，23： | 2 |
| 12 | Characterization of compost produced from separated pig manure and a variety of bulking agents at low initial C/N ratios显示文摘 | Tereza Nolan Shane M. Troy Mark G. Healy Witold Kwapinski James J. Leahy Peadar G. Lawlor | 2011 | Bioresource Technology2011，，14： | 2 |
| 13 | Serum peptidome patterns that distinguish metastatic thyroid carcinoma from cancer-free controls are unbiased by gender and age显示文摘 | Villanueva J Martorella AJ Lawlor K | 2006 | Mol Cell Proteomics2006，5，10： | 1 |
| 14 | Photosynthetic carbon assimilation and associated metabolism in relation to water deficit in higher plants 显示文摘 | Lawlor D W Cornic G | 2002 | Plant Cell & Environment2002，25，2： | 1 |
| 15 | Blood pressure, haemorrhagic stroke, and ischaemic stroke: the Korean national prospective occupational cohort study 显示文摘 | Song YM Sung J Lawlor DA Smith DG Shin Y Ebrahim S | 2004 | BM J2004，328，12： | 1 |
| 16 | Association of C-reactive protein with blood pressure and hypertension;life course confounding and mendelian randomization tests of causality显示文摘 | Davey Smith G Lawlor DA Harbord R | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 17 | Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004显示文摘 | Abigail Fraser Matthew P. Longnecker Debbie A. Lawlor | 2007 | Gastroenterology2007，，6： | 1 |
| 18 | Salmonella mutagenlcity test results for 250 chemicals 显示文摘 | HAWORTH S LAWLOR T MORTELMANS K | 1983 | Environ Mutagen1983，5，1： | 1 |
| 19 | Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4,joint macrophages,granulocyte-macrophage colony-stimulating factor,interleukin-6,and leukemia inhibitory factor显示文摘 | Lawlor KE Wong PK Campbell IK van Rooijen N Wicks IP | 2005 | Arthritis Rheum2005，52，12： | 1 |
| 20 | Development of the Stay Safe Programme显示文摘 | MacIntyre D Carr A Lawlor M | 2000 | Child Abuse Review2000，，： | 1 |
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