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| 1 | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial显示文摘 | Guglielmo Ronco Paolo Giorgi-Rossi Francesca Carozzi Massimo Confortini Paolo Dalla Palma Annarosa Del Mistro Bruno Ghiringhello Salvatore Girlando Anna Gillio-Tos Laura De Marco Carlo Naldoni Paola Pierotti Raffaella Rizzolo Patrizia Schincaglia Manuel Z | 2010 | Lancet Oncology2010，，3： | 3 |
| 2 | Lipotoxicity in the liver显示文摘Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21stcentury. With the increasing prevalence of obesity, non-alcoholic fatty liver disease is also emerging as a pandemic. While previously this pathophysiological condition was mainly attributed to triglyceride accumulation in hepatocytes,recent data show that the development of oxidative stress, lipid peroxidation, cell death, inflammation and fibrosis are mostly due to accumulation of fatty acids,and the altered composition of membrane phospholipids. In fact, triglyceride accumulation might play a protective role, and the higher toxicity of saturated or trans fatty acids seems to be the consequence of a blockade in triglyceride synthesis. Increased membrane saturation can profoundly disturb cellular homeostasis by impairing the function of membrane receptors,channels and transporters. However, it also inducesendoplasmic reticulum stress via novel sensing mechanisms of the organelle's stress receptors. The triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. These findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis.This minireview focuses on the metabolic and redox aspects of lipotoxicity and lipoapoptosis, with special regards on the involvement of endoplasmic reticulum stress responses. | Veronika Zámbó Laura Simon-Szabó Péter Szelényi va Kereszturi Gábor Bánhegyi Miklós Csala | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 3 | Effects of organic chromium supplementation to finishing lambs diet on growth performance, carcass characteristics and meat quality显示文摘The objective of this study was to evaluate supplemental organic chromium(Cr) to finishing lambs on growth performance, carcass characteristics, and meat quality. Eighteen Suffolk lambs(age(4.5±0.2) mon;(25.8±3.6) kg body weight(BW)) were randomly assigned to three levels of supplemental organic Cr(0.0, 0.2 and 0.4 mg kg–1 dry matter(DM)) in a complete random design. Growth performance was evaluated for 70 d, and then lambs were slaughtered to study carcass characteristics and chemical composition of meat. Orthogonal contrasts were performed(contrast one-average level 0.2 ppm Cr vs. average level 0.4 ppm Cr; contrast two-level 0 vs. average levels(0.2+0.4) ppm Cr). Orthogonal polynomials were used to estimate the linear and quadratic effects of Cr concentrations. Growth and carcass performance were not affected by supplemental organic Cr. Muscle conformation and leg perimeter linearly increased(P<0.05) as organic Cr level increased in the diet. Kidney fat decreased linearly(P<0.05) as supplemental Cr increased. In Longissimus dorsi(LD), the ash content decreased linearly, and shear force(kg cm–2) increased(P<0.05) as organic Cr level increased in the diet. It is concluded that organic Cr did not affect growth performance, but it improved positively the muscle conformation, reduced kidney fat, whereas in LD there was an increment in shear force in finishing carcass lambs. | Laura Moreno-Camarena Ignacio Domínguez-Vara José Bórquez-Gastelum Juan Sánchez-Torres Juan Pinos-Rodríguez Antonia Mariezcurrena-Berasain Ernesto Morales-Almaráz Abdelfattah Z M Salem | 2015 | Journal of Integrative Agriculture2015，14，3： | 2 |
| 4 | Constitutive nuclear factor-κB is required for central neuron survival显示文摘 | Asha LB Laura T Christine Z | 2002 | J Neurosci2002，22，19： | 2 |
| 5 | Determination of stavudine in human plasma and urine by high- performance liquid chromatography using a reduced sample volume显示文摘 | Marya S Neus R Laura Z | 2000 | J Chromatogr B2000，746，： | 1 |
| 6 | Mutation in gyrA and parCgenes in nalidixic acid-resistant Escherichia strains from food products, humans and animals 显示文摘 | Yoland S Myriam Z Laura B | 2003 | Antimicrob Chemother2003，51，3： | 1 |
| 7 | P38 and activating transcriptionfac- tor - 2 involvement in osteoblast osmotic response to elevated extra- cellular glucose 显示文摘 | Maid Z Sergiu B Laura RM | 2002 | J Biol Chem2002，277，37： | 1 |
| 8 | Lipase-catalyzed degradation of poly (e-caprolactone) 显示文摘 | LAURA P FRANCO P MARLI Z | 2004 | Enzyme and Microbial Technology2004，35，4： | 1 |
| 9 | Con stitutive nuclear factor- kappa B activity is required for central neuron survival显示文摘 | ASHA L B LAURA L T CHRISTINE Z | 2002 | J Neurosci2002，22，： | 1 |
| 10 | ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia显示文摘 | Laura Z Rassenti P Huynh L | | 0，，09： | 1 |
| 11 | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial显示文摘 | Guglielmo Ronco Paolo Giorgi-Rossi Francesca Carozzi Massimo Confortini Paolo Dalla Palma Annarosa Del Mistro Bruno Ghiringhello Salvatore Girlando Anna Gillio-Tos Laura De Marco Carlo Naldoni Paola Pierotti Raffaella Rizzolo Patrizia Schincaglia Manuel Z | 2010 | Lancet Oncology2010，，3： | 1 |
| 12 | Receiver-operatingcharacteristic analysis for evaluating diagnostic tests andpredictive models显示文摘 | Kelly H Z A James O'Malley Laura M | 2007 | Circulation2007，115，： | 1 |
| 13 | Quantification of biofilm production on polystyrene by Listeria, E coli and Staphylococcus aureus isolated from poultry slaughterhouse 显示文摘 | Laura B R Luciana R S Vrnicius Z C | 2010 | Brazilian J of Micro Biol2010，41，： | 1 |
| 14 | ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia显示文摘 | LAURA Z | 2004 | N Engl J Med2004，351，9： | 1 |
| 15 | Spices and herbs: their antimicmbial activity and its determination 显示文摘 | Laura L Z | 1988 | Journal of Food Safety1988，9，： | 1 |
| 16 | Impacts of a thermal power plant on the phosphorus TMDL of a reservoir 显示文摘 | Chen C W Laura Weintraub L H Z Herr J | 2000 | Environment Science & Policy2000，，3： | 1 |
| 17 | Hospice attitudes among Assis- ted living and nursing home administratory, and the long - term care hospice attitudes scale显示文摘 | Debra JD Laura H Sheryl Z | 2006 | Journal of Palliative Medicine2006，9，6： | 1 |
| 18 | Resting Energy Expenditure in Overweight and Obese Adults :Agreement Between Indirect Calorimetry and Predictive Formulas 显示文摘 | JANE Z RIVA TD LAURA BG | 2010 | Topics in Clin Nutr2010，25，2： | 1 |
| 19 | Assessing the Effect of Reform in Teacher Education:An Evaluation of the 5-year Program at Trinity University显示文摘 | LAURA M&VAN Z | 1998 | Journal of Teacher Education1998，49，2： | 1 |
| 20 | Laboratory evaluation of polyurethane foam-granular adsorbent sandwich cartridges for collecting chlorophenols from air显示文摘 | Gregory W P Laura L M Mark T Z | 1992 | Anal Chem1992，64，22： | 1 |
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