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| 1 | Epigenetics and DNA methylation in cancer显示文摘Epigenetic is the study of those alterations regulating gene expression without altering DNA sequence and inherited by transmission through cell division. Mutational and epimutational events that alterate cellular growth and division are combined in carcinogenesis. Advances in genome and epigenome-wide analysis identify DNA hypomethylation,hypermethylation of tumor suppressor genes,aberrant histone modifications and/or specific mi RNA expression profiles to contribute to tumor initiation and progression. The major challenge for cancer researchers is to enlighten the complex relationship between the epigenetic and genetic machinery in order tooptimize combined therapies,reducing chemoresistance and minimizing adverse effects in cancer patients. In this review we will cover many distinct aspects of epigenetic phenomenon. Firstly,we will globally explain the most common epigenetic events and their effects on gene expression regulation. Secondly,we will review the evidence of the correlation between epigenetics and cancer progression,focusing in particular on the effect of aberrant hypo- and hyper-methylation. We will also consider the main methods currently used for methylation analysis,covering both locus-specific technologies and genome-wide analysis. Finally,we will discuss the introduction of novel epigenetic drugs in combination with conventional treatments in order to develop more effective cancer therapies. Such information could help in understanding the important role of epigenetics in cancer. | Laura Lattanzio Cristiana Lo Nigro | 2015 | World Journal of Translational Medicine2015，4，1： | 3 |
| 2 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 3 | Closed versus open endotracheal suctioning in preterm infants:Effects on cerebral oxygenation and blood volume显示文摘 | Mosca FA Colnaghi M Lattanzio M | 1997 | Biol Neonate1997，72，1： | 1 |
| 4 | Current analytical methods for trichothecene my- cotoxins in cereals 显示文摘 | Veronica M T Lattanzio Michelangelo Pascale Angelo Visconti | 2009 | Trends in Analytical Chemistry2009，28，6： | 1 |
| 5 | Verbascosides hom olive mill waste water: assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/Caco -2 model system 显示文摘 | Cardinali A Linsalata V Lattanzio V | 2011 | J Food Sci2011，76，2： | 1 |
| 6 | Analysis of T-2 and HT-2 toxins in cereal grains by immunoaffinity clean-up and liquid chromatography with fluorescence detection显示文摘 | Angelo Visconti Veronica Maria Teresa Lattanzio Michelangelo Pascale Miriam Haidukowski | 2005 | Journal of Chromatography A2005，，1： | 1 |
| 7 | Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome显示文摘 | Pandolfi C Zugaro A Lattanzio F | 2008 | Metabolism2008，57，7： | 1 |
| 8 | Comparison of topical steroids for acute anterior uveitis显示文摘 | Samudre SS Lattanzio FA Jr Williams PB | 2004 | J Ocul Pharmacol Ther2004，20，6： | 1 |
| 9 | Effect of age and activi- ty on knee joint proprioception显示文摘 | Petreila RJ Lattanzio PJ Nelson MG | 1997 | Am J Phys Med Rehabil1997，76，3： | 1 |
| 10 | Trea tment of acute biliary pancreatitis in the aged in the endol, aparoscopic rea 显示文摘 | Schier troma M Lattanzio R Rsetti A | 1999 | Minerva Chir1999，54，： | 1 |
| 11 | Development and in- house validation of a robust and sensitive solid-phase extraction liquid chromatography/tandem mass spectrometry method for the quantitative determination of aflatoxins B1 ,B2, G1 , G2, ochratoxin A, deoxynivalenol, zearalenone, T-2 and HT- 2 toxins in cereal-based foods 显示文摘 | Lattanzio V M T Gatta S D Suman M | 2011 | Rapid Communications in Mass Spectrometry2011，25，13： | 1 |
| 12 | Treatment of acute biliary pancreatitis in the aged in the endoloparoscopicera显示文摘 | Schiertroma M Lattanzio R Risetti A | 1999 | Minerva Chir1999，54，： | 1 |
| 13 | Can adoption of regular exercise later in life prevent metabolic risk for cardiovascular disease显示文摘 | Petrella RJ Lattanzio CN Demeray A | 2005 | Diabetes Care2005，28，3： | 1 |
| 14 | Analysis of T-2 and HT-2 Toxins in cereal grains by immunoaffinity clean-up and liquid chromatography with fluorescence detection 显示文摘 | Visconti A Lattanzio V M T Pascale M | 2005 | J Chromatogr A2005，1075，： | 1 |
| 15 | Effect of age and activity on knee joint proprioception显示文摘 | Petrella RJ Lattanzio PJ Nelson MG | 1995 | Am J Sports Med1995，23，： | 1 |
| 16 | Simultaneous de- termination of aflatoxins, ochratoxin A and fusarium toxins in maize by liquid chromatography/tandem mass spectrometry after multitoxin immunoaffinity clean-up 显示文摘 | Lattanzio VMT Solfrizzo M Powers S | 2007 | Rapid Communications in Mass Spectrometry2007，21，20： | 1 |
| 17 | Production of aluminium and the heavy magnesium isotopes in asymptotic giant branch stars 显示文摘 | Karakas A I Lattanzio J C | 2003 | Publication of the Astronomical Society of Australia2003，20，3： | 1 |
| 18 | Globe artichoke:a functional food and source of nutraceutical ingredients显示文摘 | Lattanzio V Kroon P A Linsalata V | | 0，，02： | 1 |
| 19 | Photofission production of technetium and synthetic asymptotic giant branch evolution 显示文摘 | LATTANZIO John C ROBERT A Malaney | 1989 | ApJ1989，347，： | 1 |
| 20 | Changers of topoisomerase Ⅱ alpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival显示文摘 | Tinari N Lattanzio R Natoli C | | 0，，05： | 1 |
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