5篇
您的检索式：作者名="Lars Hovgaard"
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| 1 | Dextran hydrogels for colon-specific drug delivery显示文摘 | Lars Hovgaard Helle Br?ndsted | 1995 | Journal of Controlled Release1995，，1： | 1 |
| 2 | The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery显示文摘Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores.In this study,we demonstrate that the upregulated intestinal transporter(PCFT),which reaches a maximum of 12.3-fold expression in the intestinal epithelial cells of diabetic rats,mediates the uptake of the folic acid-grafted nanoparticles(FNP).Specifically,the upregulated PCFT could exert its function to mediate the endocytosis of FNP and efficiently stimulate the traverse of FNP across enterocytes by the lysosome-evading pathway,Golgi-targeting pathway and basolateral exocytosis,featuring a high oral insulin bioavailability of 14.4%in the diabetic rats.Conversely,in cells with relatively low PCFT expression,the positive surface charge contributes to the cellular uptake of FNP,and FNP are mainly degraded in the lysosomes.Overall,we emphasize that the upregulated intestinal transporters could direct the uptake of ligand-modified nanoparticles by mediating the endocytosis and intracellular trafficking of ligand-modified nanoparticles via the transporter-mediated pathway.This study may also theoretically provide insightful guidelines for the rational design of transporter-targeted nanoparticles to achieve efficient drug delivery in diverse diseases. | Jingyi Li Yaqi Zhang Miaorong Yu Aohua Wang Yu Qiu Weiwei Fan Lars Hovgaard Mingshi Yang Yiming Li Rui Wang Xiuying Li Yong Gan | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 3 | Characterization and physical stability of spray dried solid dispersions of probucol and PVPK30-K30显示文摘 | Pia Thybo Betty L Pedersen Lars Hovgaard | 2008 | J Pharm Dew Tee2008，13，： | 1 |
| 4 | Characterization and Physical Stability of Tolfenamic Acid-PVP K30 Solid Dispersions显示文摘 | Pia Thybo Jakob Kristensen Lars Hovgaard | 2007 | Pharmaceutical Development and Technology2007，，1： | 1 |
| 5 | Quality by design-Spray drying of insulin intended for inhalation显示文摘 | Morten Jonas Maltesen Simon Bjerregaard Lars Hovgaard | 2008 | European Journal of Pharmaceutics and Biopharmaceutics2008，70，： | 1 |
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