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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Integrated design and analysis of intakes and nozzles in air- breathing engines显示文摘 | FERLAUTO M LAROCCA F & ZANNETTI L | 2002 | Journal of Propulsion and Power2002，18，1： | 1 |
| 3 | Quercetin Inhibits the Growth of Leukemic Progenitors and Induces the Expression of Transforming Growth Factor-β1 in These Cells 显示文摘 | Larocca L M Teofili L Sica S | 1995 | Blood1995，，： | 1 |
| 4 | Tamoxifen modulates the expression of Ki67,apoptosis,and microvessel density in cervical cancer显示文摘 | Ferrandina G Ranelletti F O Larocca L M | 2001 | Clin Cancer Res2001，7，9： | 1 |
| 5 | Toughening of poly(butylene terephthalate ) by AES lerpolymer 显示文摘 | LAROCCA N M HAGE Jr E PESSAN L A | 2004 | Polymer2004，45，： | 1 |
| 6 | Toughening of poly (butylene-terephthalate) by AES terpolymer显示文摘 | LAROCCA N M HAGE E PESSAN L A | | 0，，15： | 1 |
| 7 | Advances in understanding the pathogenesis of familial thrombocythaemia显示文摘 | Teofili L Larocca LM | | 0，，06： | 1 |
| 8 | Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors显示文摘 | LAROCCA L M TEOFILI L LEONE G | 1991 | Br J Haematol1991，79，4： | 1 |
| 9 | Effect of Antiplasticisation on the Volumetric, Gas Sorption and Transport Properties of Polyetherimide 显示文摘 | Larocca M M Pessan L A | 2003 | J Membr Sci2003，218，： | 1 |
| 10 | Reduced nitric oxide synthase and cyclo-oxygenase activity in the uterus of non-obese diabetic mice显示文摘 | Roca V Larocca L Calafat M | 2006 | Reproduction2006，132，： | 1 |
| 11 | Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination,role of heat-shock protein-70显示文摘 | LAROCCA L M MAGGIANO N | 1997 | International Journal of Cancer1997，73，1： | 1 |
| 12 | Treatment of brain tumors 显示文摘 | ASHBY L LAROCCA R RYKEN T | 2005 | N Engl J Med2005，352，22： | 1 |
| 13 | Vasoactive intestinal peptide inhibits TNF- alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands 显示文摘 | Calafat M Larocca L Roca V | 2009 | Arthritis Res Ther2009，11，2： | 1 |
| 14 | Acute hemorrhagic leukoencephalitis in patients with acute myeloid leukemia in hematologic complete remission显示文摘 | Pagano L Larocca LM Vaccario ML | 1999 | Haematologica1999，84，： | 1 |
| 15 | Vasoactive intestinal peptide inhibits tumor necrosis factor-alpha-induced apoptotic events in acinar ceils from non-obese diabetic mice submandibular glands 显示文摘 | Calafat M Larocca L Roca V | 2009 | Arthritis Res Ther2009，11，2： | 1 |
| 16 | Vasoactive intesti- nal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sjogren's syndrome显示文摘 | Hauk V Calafat M Larocca L | 2011 | Clin Exp Immunol2011，166，3： | 1 |
| 17 | Immunopathology of nasal polyps:an immunohistochemical approach显示文摘 | Larocca L M Maggiano N Capelli A | 1989 | Ann Allergy1989，63，6： | 1 |
| 18 | Effect of reactive compatibilization on the properties of poly (butylene terephthalate)/ aerylonitrile-ethylene-propylene-diene-styrene blends显示文摘 | Larocca N M Hage E J Pessan L A | 2005 | joumal of Polymer Science Part B: Polymer Physics2005，43，10： | 1 |
| 19 | Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease显示文摘 | Teofili L Di Febo AL Pierconti F Maggiano N Bendandi M Rutella S Cingolani A Di Renzo N Musto P Pileri S Leone G Larocca LM | | 0，，： | 1 |
| 20 | Expression profile of MUM1 ? IRF4,BCL-6 and CD138 ? syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas显示文摘 | Carbone A Gloghini A Larocca L | 2001 | Blood2001，97，3： | 1 |
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