| 2 | A case of polymyositis with ophthalmoplegia Laboratory examinations显示文摘OBJECTIVE: Polymyositis (PM) mainly involves proximal limb and trunk muscles. Ocular muscles are not affected, except in rare cases with both PM and myasthenia gravis (MG). Thus, the results of laboratory examinations in such a patient deserve to be reported. METHODS: To analyze the clinical, imaging and pathology datas on a 65-year-old woman patient with PM with complex symptoms, who presented mainly ophthalmoplegia. The patient consented to all examinations and the hospital Ethics Committee approved the study. The laboratory examinations included creatine kinase (CK), ENA, tumor marker, function of thyroid, cranial MRI, and electromyogram (EMG). Biopsy of the left quadriceps femoris was performed, frozen specimens were stained with hematoxylin and eosin, ATPase, NADH tetrazolium reductase, periodic acid Schiff, oil red O, modified Gomory trichrome and MHC-I, to investigate the pathology of muscle fibers RESULTS: Laboratory results showed: CK, 108.32μkat/L; antinuclear antibody: (+); ENA, (–); tumor marker, (–); normal thyroid function, MRI showed no abnormal signals in brain and extraocular muscles. Electromyography of the bilateral deltoid, biceps brachii, musculus quadriceps fexoris, anterior tibialis showed fibrillation potentials, positive potentials and short-duration, small-amplitude polyphasic potentials on voluntary movements with a full interference pattern on mild exertion. Repetitive stimulation did not result in any increment or decrement in these potentials. A muscle biopsy of the left quadriceps femoris showed many small round muscle fibers without peripheral bundle distribution and apparent myofiber degeneration, necrosis and phagocytosis. There were several focal lymphocyte infiltrations. MHC-I immunohistochemical staining was positive in most fibers revealing inflammatory infiltration of normal fibers with MHC-I expression. CONCLUSION: This patient showed increased CK, typical triad of myopathy in EMG, and apparent degeneration and necrosis in biopsy of quadriceps femoris. Therefore, the diagnosis of PM and involvement of extraocular muscles were definite. | Shunchang Han Chuanqiang Pu Xusheng Huang Senyang Lang Weiping Wu | 2008 | Neural Regeneration Research2008，3，3： | 0 |
| 3 | Effect of swimming training on neural microcirculation in rats with sciatic nerve compression A study based on laser Doppler flowmetry显示文摘Microcirculation of the peripheral nerve is necessary for neural growth and regeneration.However,technical limitations have limited studies in this area.The few studies conducted have concerned active exercise effects on microcirculation of the peripheral nerve.Using an animal experiment,this study evaluated the effect of swimming training on microcirculation of injured peripheral nerve by laser Doppler flowmetry.The results showed that the blood vessel at the distal end of the peripheral nerve was the main blood supply for the nerve,and the internal blood supply for the nerve had strong compensatory ability.Swimming training promoted the functional recovery of rats with sciatic nerve injury and the regeneration of myelin sheath and blood vessels,but had no impact on neural blood flow. | Yueming Gao Xinglin Wang Senyang Lang Lining Zhang Wei Suo Tianyu Jiang Jingping Fan | 2010 | Neural Regeneration Research2010，5，19： | 0 |
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