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| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Disturbance response in vegetation-towards a global prespective on functional traits显示文摘 | Mclntyre S Lavorel S Landsberg J | 1999 | Journal of Vegetation Science1999，10，： | 1 |
| 3 | Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption显示文摘 | Felix SB Staudt A Landsberger M | 2002 | J Am Coll Cardiol2002，39，4： | 1 |
| 4 | The effects of harmful algal blooms on aquatic organisms显示文摘 | Landsberg J H | 2002 | Reviews in Fisheres Science2002，10，2： | 1 |
| 5 | Climate of the urban biosphere显示文摘 | Landsberg 1973 | 1973 | Biometeorology1973，5，2： | 1 |
| 6 | Stimulation of the sympathetic nervous system during sucrose feeding显示文摘 | Yonug JB Landsberg L | 1977 | Nature1977，269，： | 1 |
| 7 | Scale - related effects of grazing on native plant communities in an arid Rangeland region of South Australia显示文摘 | Landsberg J James C D Maconochie J Nicholls A O Stol J and Tynan R | 2002 | Journal of Applied Ecology2002，39，： | 1 |
| 8 | Hypertension and associated metabolic abnormalities- the role of insulin resistance and the sympathoadrenal system 显示文摘 | Reaven GM Lithell H Landsberg L | 1996 | N Engl JMed1996，334，： | 1 |
| 9 | Screening for de novo anti-human leukocyte antigen antibodies in nonsensitized kidney transplant recipients does not predict acute rejection显示文摘 | Gill JS Landsberg D Johnston O | | 0，，02： | 1 |
| 10 | Melanomasresist T - cell therapy through inflammation 一 inducedreversible dedifferentiation显示文摘 | Landsberg J Kohlmeyer J Renn M | 2012 | Nature*2012，490，74： | 1 |
| 11 | A computer-assisted anatomical study of the nasofrontal region显示文摘 | Landsberg R Friedman M | 2001 | Laryngoscope2001，111，： | 1 |
| 12 | E2Fs regulate adipocyte differentiation 显示文摘 | Fajas L Landsberg RL Huss-Garcia Y | 2002 | Dev Cell2002，3，1： | 1 |
| 13 | An evaluation of atmospheric deposition of trace elements into the Great Lakes显示文摘 | Biegalski S Landsberger S | 1999 | Biological Trace Element Research1999，7172，1： | 1 |
| 14 | Intertemporal Price Discrimination and Sales Strategy under Incomplete Information显示文摘 | Landsberger M Meilijson I | 1985 | RAND Journal of Economics (S0741-6261)1985，16，3： | 1 |
| 15 | Obesity,metabolism,and sympathetic nervous system显示文摘 | Landsberg L Krieger DR | | 0，，： | 1 |
| 16 | Cetivastatin reduces cytokine - induced surface expression of ICAM - 1 via increased shedding in human endothelial cells显示文摘 | Landsberger M Wolff B Jantzen F | 2007 | Atherosclerosis2007，190，1： | 1 |
| 17 | Evaluation of Flow Scintillation Analysis for the Determination of Sr-90 in Bioassay Samples显示文摘 | Plionis A A Gonzales E R Landsberger S | 2009 | Appl Radiat Isot2009，67，1： | 1 |
| 18 | Canadianmulticentre trial of tacrolimus/azathioprine/steroids versustacrolimus/mycophenolate mofetil/steroids versus Neoral/mycophenolate mofetil/steroids in renal transplantation显示文摘 | Busque S Shoker A Landsberg D | 2001 | Transplant Proc2001，33，3： | 1 |
| 19 | Diabetes and hypertension: pathogenesis, prevention and treatment显示文摘 | Landsberg L Molitch M | 2004 | Clin Exp Hy- pertens2004，26，78： | 1 |
| 20 | Plant functional classifications: from general groups to specific groups based on response to disturbance显示文摘 | Lavorel S McIntyre S Landsberg J | 1997 | Trends in Ecology & Evolution1997，12，12： | 1 |
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