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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 2 | Osteoclasts are not a source of SLIT3显示文摘The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on the effects of SLIT3 on osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable SLIT3 expression during human or mouse osteoclastogenesis and the only modest SLIT3-mediated effects on osteoclast differentiation. Conditional deletion of SLIT3 in cathepsin K(CTSK)-positive cells, including osteoclasts, had no effect on the number of osteoclast progenitors, in vitro osteoclast differentiation, overall bone mass, or bone resorption/formation parameters. Similar results were observed with the deletion of SLIT3 in Lys M-positive cells, including osteoclast lineage cells. Consistent with this finding, bone marrow chimeras made from Slit3-/-donors that lacked SLIT3 expression at all stages of osteoclast development displayed normal bone mass relative to controls. Taken in context, multiple lines of evidence were unable to identify the physiologic function of osteoclast-derived SLIT3,indicating that osteoblasts are the major source of skeletal SLIT3. | Na Li Kazuki Inoue Jun Sun Yingzhen Niu Sarfaraz Lalani Alisha Yallowitz Xu Yang Chao Zhang Rong Shen Baohong Zhao Ren Xu Matthew B.Greenblatt | 2020 | Bone Research2020，8，2： | 4 |
| 3 | Modulating chemokines:more lessons from viruses显示文摘 | LALANI A S BARRETT J W MCFADDEN G | 2000 | Immunol Today2000，21，2： | 1 |
| 4 | Effects of vagal denervation on cardiorespiratory and behavioral responses in the newborn lamb显示文摘 | Lalani S Remmers JE Green FH | 2001 | J Appl Physiol2001，91，5： | 1 |
| 5 | Interleukin-10:biology,role in inflammation and autoimmunity显示文摘 | Bhol K Ahmed AR | 1997 | Ann Allergy Asthma Immunol1997，79，6： | 1 |
| 6 | Role of computed tomography and magnetic resonance imaging for deep venous thrombosis and pulmonary embolism 显示文摘 | Kanne JP Lalani TA | 2004 | Circulation2004，109，12： | 1 |
| 7 | IL-2 regulation of soluble IL-2 receptor levels following thermal injury显示文摘 | Teodorczyk-Injeyan JA Sparkes BG Lalani S | 1992 | Clin Exp Immunol1992，90，1： | 1 |
| 8 | Myostatin and insulin-like growth factor-Ⅰ and -Ⅱ expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight 显示文摘 | LALANI R BHASIN S BYHOWER F | 2000 | J Endocrinol2000，167，3： | 1 |
| 9 | Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens显示文摘 | Rubinstein E Lalani T Corey GR | 2011 | Clin Infect Dis2011，52，1： | 1 |
| 10 | Abnormal signal overaged electrocardiogram(ASECG) in obesity 显示文摘 | Lalani AP kanna B John J | 2000 | Obese Res2000，8，： | 1 |
| 11 | Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells显示文摘 | Golding M Lalani EN | 1997 | J Hepatol1997，26，： | 1 |
| 12 | Transdermal estra2diol therapy for advanced prostate cancer forward to the past 显示文摘 | Ockrim JL Lalani EN Laniado ME | 2003 | J Urol2003，169，5： | 1 |
| 13 | Transdermal estradiol improves bone density when used as single agent therapy for prostate cancer显示文摘 | Ockrim JL Lalani EN Banks LM | 2004 | J Urol2004，172，： | 1 |
| 14 | Romidepsin (FK228) combined with cisplatin stimulates DNA dam- age-induce cell death in ovarian cancer显示文摘 | Wilson AJ Lalani AS Wass E | 2012 | Gynecol On- col2012，127，3： | 1 |
| 15 | Extractables/Leaehables from Plastic Tubing Used in Product Manufacturing显示文摘 | JENKE DR STORY J LALANI R | 2006 | lnt J Pharm2006，315，12： | 1 |
| 16 | Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor显示文摘 | Lin J Lalani AS Harding TC | 2005 | Cancer Res2005，65，15： | 1 |
| 17 | c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells显示文摘 | LALANI S LEAVENWORTH J W | 2007 | Eur J Immunol2007，37，10： | 1 |
| 18 | Telavancin versus van-comycin for hospital-acquired pneumonia due to gram-positivepathogens 显示文摘 | Rubinstein E Lalani T Corey GR | 2011 | Clinical infectious diseases : an official publication ofthe Infectious Diseases Society of America2011，52，1： | 1 |
| 19 | Computed tomography diagnosis of ischemia and complete obstructtionin small bowel obstruction:asystematicreview显示文摘 | Mallo R D SalemL K Lalani T | 2005 | J Gastrointest Surg2005，9，5： | 1 |
| 20 | Biomechanical evaluation of the pins of a mandibular external distraetor显示文摘 | Gateno J Kim KW Lalani Z | | 0，，： | 1 |
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