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| 1 | Non-surgical treatment of hilar cholangiocarcinoma显示文摘Cancer of the biliary confluence also known as hilar cholangiocarcinoma(HC)or Klatskin tumor,is a rare type of neoplastic disease constituting approximately 40%-60%of intrahepatic malignancies,and 2% of all cancers.The prognosis is extremely poor and the majority of Klatskin tumors are deemed unresectable upon diagnosis.Most patients with unresectable bile duct cancer die within the first year after diagnosis,due to hepatic failure,and/or infectious complications secondary to biliary obstruction.Curative treatments include surgical resection and liver transplantation in highly selected patients.Nevertheless,very few patients are eligible for surgery or transplant at the time of diagnosis.For patients with unresectable HC,radiotherapy,chemotherapy,photodynamic therapy,and liver-directed minimally invasive procedures such as percutaneous image-guided ablation and intra-arterial chemoembolization are recommended treatment options.This review focuses on currently available treatment options for unresectable HC and discusses future perspectives that could optimize outcomes. | Riccardo Inchingolo Fabrizio Acquafredda Valentina Ferraro Letizia Laera Gianmarco Surico Alessia Surgo Alba Fiorentino Stefania Marini Nicola de'Angelis Riccardo Memeo Stavros Spiliopoulos | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 5 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Membrane bioreactor sludge theology at different solid retention times 显示文摘 | Laera G Giordano G PoUiee A | 2007 | Water Research2007，41，18： | 1 |
| 4 | Effects of sludge retention tine on the performance of a membrane bioreactor treating municipal sewage 显示文摘 | Pollice A Laera G Saturno D | 2008 | Joumal of Menbrane Science2008，317，12： | 1 |
| 5 | Physical characteristics of the sludge in a complete retention membrane bioreactor显示文摘 | Pollice A Giordano C Laera G | 2007 | Water Research2007，41，8： | 1 |
| 6 | Membrane bioreactor sludge rheology at different solid retention times 显示文摘 | G Laera C Giordano A Pollice | 2007 | Water Research2007，41，18： | 1 |
| 7 | Improved functions of human hepatocytes on NH3 plasma-grafted PEEK-WC-PU membranes 显示文摘 | Salerno S Piscioneri A Laera S | 2009 | Biomaterials2009，30，26： | 1 |
| 8 | Biomass growth and activity in a membrane bioreactor with complete sludge retention显示文摘 | POLLICE A LAERA G BLONDA M | 2004 | Water Research2004，7，38： | 1 |
| 9 | Tertiary filtered municipal wastewater as alternative water source in agriculture: a field investigation in Southern Italy显示文摘 | Pollice A Lopez A Laera G | 2004 | Science of the Total Environment2004，324，： | 1 |
| 10 | Physical characteristics of the sludge in a complete retention membrane bioreaetor显示文摘 | Pollice A Giordano C Laera G | 2007 | Water Research2007，41，： | 1 |
| 11 | Membrane bioreactor sludge rheology at different solid retention times显示文摘 | Laera G Giordano C Pollice A | 2007 | Water Research2007，41，： | 1 |
| 12 | Effects of sludge retention time on the performance of a membrane bioreactor treating municipal sewage 显示文摘 | Alfieri Pollice Giuseppe Laera Daniela Saturno | 2008 | Journal of Membrane Science2008，317，12： | 1 |
| 13 | Tertiary filtered municipal wastewater as alternative water source in agriculture:a field investigation in Southern Italy显示文摘 | Pollice A Lopez A Laera G | 2004 | Science of the Total Environment2004，324，123： | 1 |
| 14 | H2/NH3Plasma-grafting of PEEK WC-PU Membrane to Improve Their Cyto-compatibility with Hepatoeytes显示文摘 | Laera S Lopez L De B | 2009 | Plasma Processes and Polymers2009，6，1： | 1 |
| 15 | Effects of sludge retention time on the performance of a membrane bioreac- tor treating municipal sewage 显示文摘 | Pollice A Laera G Saturno D | 2008 | J Membr Sci2008，317，12： | 1 |
| 16 | Physical characteristics of the sludge in a complete retention membrane bioreactor显示文摘 | A. Pollice C. Giordano G. Laera D. Saturno G. Mininni | 2007 | Water Research2007，，8： | 1 |
| 17 | Tertiary filtered mu- nicipal wastewater as ahernative water source in agricul- ture: a field investigation in Southern Italy 显示文摘 | PolliceA Lopez A Laera G | 2004 | Science of the Total Environment2004，324，13： | 1 |
| 18 | Membrane bioreactor sludge rheology at different solid retention times显示文摘 | G. Laera C. Giordano A. Pollice D. Saturno G. Mininni | 2007 | Water Research2007，，18： | 1 |
| 19 | Effects of sludge retention time on the performance of a membrane bioreactor treating municipal sewage显示文摘 | Alfieri Pollice Giuseppe Laera Daniela Saturno | 2008 | J Membrane Sci2008，317，2： | 1 |
| 20 | Effects of sludge retention time on the performance of a membrane bioreactor treating municipal sewage 显示文摘 | Pollice A Laera G Saturno D | 2008 | Journal of Membrane Science2008，317，12： | 1 |
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