|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer显示文摘Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug concentrations.Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy.The patient was treated with a combination of gemcitabine and oxaliplatin using HAI.The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI.The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper.HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials. | Boris Guiu Julie Vincent Séverine Guiu Sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 2 | Degarelix as a new antiangiogenic agent for metastatic colon cancer?显示文摘Recently,follicle stimulating hormone receptor was found to be selectively expressed by endothelial cells on tumor-associated blood vessels in a wide range of human cancers.In this context,we hypothesized that degarelix,a new gonadotropin-releasing hormone receptor antagonist developed for patients with prostate cancer,may have antiangiogenic effects via its capacity to block follicle stimulating hormone(FSH)production. We report the case of a patient with metastatic colon cancer exhibiting tumor progression after failure of all conventional chemotherapeutic regimens.The addition of degarelix to the last chemotherapeutic regimen was proposed as compassionate treatment.Degarelix induced a rapid decrease in FSH level.This treatment induced radiological stabilization and carcinoembryonic antigen stabilization during 1 year.Contrast-enhanced ultrasonography demonstrated reduction of tumor vas-clature.This case represents the first report of an antitumoral effect of degarelix in metastatic colon cancer and suggests an antiangiogenic property of this drug. | Francois Ghiringhelli Nicolas Isambert Sylvain Ladoire | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 3 | Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients显示文摘AIM: To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer(mCRC). METHODS: Survival and patient characteristics from consecutive mCRC patients treated in the Centre Georges Francois Leclerc, Dijon, France between January 2001 and December 2011 were analyzed. Patient and tumor characteristics, hematological toxicity(neutropenia, anemia, and thrombocytopenia), and type of chemotherapy received were recorded. RESULTS: We retrospectively analyzed data from 399 consecutive patients with mCRC who received at least one line of chemotherapy. Median follow up was 6.3 years. Eighty-eight percent of the patients received more than two lines of chemotherapy. By univariate analysis, whatever their grade, neutropenia and thrombocytopenia occurring during the first two lines of chemotherapy were significantly associated with better overall survival(HR = 0.55, 95%CI: 0.43-0.70, P < 0.0001 and HR = 0.70, 95%CI: 0.56-0.88, P = 0.025 respectively). In contrast, anemia during chemotherapy was significantly associated with poorer overall survival(HR = 1.9, 95%CI: 1.22-2.97, P = 0.005). Multivariate analysis revealed that both neutropenia and thrombocytopenia were significantly associated with better overall survival: HR = 0.43, 95%CI: 0.29-0.64, P < 0.0001 and HR = 0.69, 95%CI: 0.49-0.98, P = 0.036, respectively. CONCLUSION: These data suggest that occurrence of neutropenia or thrombocytopenia during first- or second-line chemotherapy for mCRC is associated with better survival. | Laurie Rambach Aurelie Bertaut Julie Vincent Veronique Lorgis Sylvain Ladoire Francois Ghiringhelli | 2014 | World Journal of Gastroenterology2014，20，6： | 2 |
| 4 | Sirolimus,bevacizumab,5-Fluorouracil and irinotecan for advanced colorectal cancer:A pilot study显示文摘AIM:To evaluate the efficacy and the safety of combined 5-Fluorouracil,irinotecan,bevacizumab and sirolimus in refractory advanced colorectal carcinoma. METHODS:We initiated a regimen with at day 1 an injection(iv)of bevacizumab at 5 mg/kg,followed by 180 mg/m 2 irinotecan,followed by Leucovorin 400 mg/m 2 ,followed by a 5-Fluorouracil bolus 400 mg/m 2 and a 46-h infusion 2400 mg/m 2 .Sirolimus was given orally as continuous administration of 2 mg twice a day every days.This treatment was repeated every 14 d. RESULTS:A total of 12 patients were enrolled. All patients presented with metastatic disease that had failed at least three lines of chemotherapy that contained oxaliplatin,irinotecan and bevacizumab. Cetuximab failure was also observed in all K-Ras wildtype patients.The median number of cycles was 8.5 (range 2-20)and clinical benefit was observed in eight patients.The median time to progression was 5 mo and the median survival was 8 mo.Grade 3 neutropenia developed in four patients,and grade 3 diarrhea and stomatitis in two. CONCLUSION:The combination regimen of 5-Fluorouracil,irinotecan,bevacizumab and sirolimus in advanced colorectal carcinoma after failure of classical treatment is feasible and promising.Further evaluation of this combination is required. | Francois Ghiringhelli Boris Guiu Bruno Chauffert Sylvain Ladoire | 2009 | World Journal of Gastroenterology2009，15，34： | 2 |
| 5 | Serum procalcitonin eleva- tion in critically ill patients at the onset of bacteremia caused by either Gram-negative or Gram-positive bacteria 显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，8，： | 1 |
| 6 | Tumor exosome -mediated MDSC activation 显示文摘 | Mignot G Chalmin F Ladoire S | 2011 | The American Journal ofPathology2011，178，3： | 1 |
| 7 | Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by eitherGram negative or Gram positive bacteria 显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，8，： | 1 |
| 8 | Membrane-associated Hsp72from tumor-derived exosomes mediates STAT3-dependent immunosup-pressive function of mouse and human myeloid-derived suppressorcells显示文摘 | Chalmin F Ladoire S Mignot G | 2010 | J Clin Invest2010，120，2： | 1 |
| 9 | Serum procalcitonin elevationin critically ill patients at the onset of bacteremia caused by eitherGram negative or Gram positive bacteria显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，81，： | 1 |
| 10 | Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，8，1： | 1 |
| 11 | Serum procalci- tonin elevation in critically ill patients at the onset of bactere mia caused by either gram negative or gram positive bacteria 显示文摘 | CHARLES P E LADOIRE S AHO S | 2008 | BMC Infect Dis2008，8，： | 1 |
| 12 | Visceral fat area as a new independent predictive factor of survival in patients with meta- static renal cell carcinoma treated with antiangiogenic agents 显示文摘 | Ladoire S Bonnetain F Gauthier M | 2011 | Oncologist2011，16，1： | 1 |
| 13 | Serum proealcitonin elevation in critically ill patients at the onset of baeteremia caused by either gram negative or gram positive baeteria显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，8，： | 1 |
| 14 | Prognostic role of FOXP3^+ regn-latory T cells infiltrating human carcinomas:the paradox of colorectal cancer 显示文摘 | Ladoire S Martin F Ghiringhelli F | 2011 | Cancer Immunol Immunother2011，60，7： | 1 |
| 15 | Prognostic role of FOXP3 + regulatory T cells infiltrating human carcinomas:the paradox of colorectal cancer显示文摘 | Ladoire S Martin F Ghiringhelli F | 2011 | Cancer Immunol Immunother2011，60，7： | 1 |
| 16 | Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘 | Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert | 2007 | Cancer Immunology Immunotherapy2007，，5： | 1 |
| 17 | Membrane-associated Hsp72from tumor-derived exosomes mediates STAT3-dependent immunosup pressive function of mouse and human myeloid-derived suppressor cells显示文摘 | Chalmin F Ladoire S Mignot G | 2010 | J Clin Invest2010，120，2： | 1 |
| 18 | Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria显示文摘 | Charles PE Ladoire S Aho S | 2008 | BMC Infect Dis2008，8，： | 1 |
| 19 | Presence of Foxp3 expres- sion in tumor cells predicts better survival in HER2-overexpress- ing breast cancer patients treated with neoadjuvant chemotherapy 显示文摘 | Ladoire S Arnould L Mignot G | 2011 | Breast Cancer Res Treat2011，125，2： | 1 |
| 20 | Metronomic oral cy- clophosphamide prednisolone chemotherapy is an effective treat- ment for metastatic hormone-refractory prostate cancer after doc- etaxel failure显示文摘 | Ladoire S Eymard J C Zanetta S | 2010 | Anticancer Res2010，30，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员